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Bacteria can cause life-threatening infections, such as pneumonia, meningitis, or sepsis. Antibiotic therapy is a mainstay of treatment, although antimicrobial resistance has drastically increased over the years. Unfortunately, safe and effective vaccines against most pathogens have not yet been approved, and thus developing alternative treatments is important. We analyzed the efficiency of factor
Functioning of the immune system requires the coordinated expression and action of many genes and proteins. With the emergence of high-throughput technologies, a great amount of molecular data is available for the genes and proteins of the immune system. However, these data are scattered into several databases and literature and therefore integration is needed.
In this study, we present integrated quantitative proteome, transcriptome, and methylome analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) populations. From the characterization of more than 6,000 proteins, 27,000 transcripts, and 15,000 differentially methylated regions (DMRs), we identified coordinated changes associated with early differentiation steps. DMRs show
One problem with web servers is that they are sensitive to overload. The servers may become overloaded during temporary traffic peaks when more requests arrive than the server is designed for. Because overload usually occurs rather seldom, it is not economical to overprovision the servers for these traffic peaks, instead admission control mechanisms can be implemented in the servers. This pa per i
The idea behind the service life model presented in this report was published in 1979. It has thereafter been described and developed in a number of reports and papers. The basis of the model is the observation that a well-defined critical, or maximum allowable, moisture content exists, above which the material is severely damaged by frost, and below which it is unharmed also when freezing is repe
Purpose: This paper aims to review total quality management (TQM) literature in the past three decades to identify the quality related key terms, to analyse their linkage among the identified key terms and their developmental trends. Design/methodology/approach: Bibliometric and statistical methods are used to analyse article titles published in the Total Quality and Business Excellence journal du
The rapid development of containerization technology comes with remarkable benefits for developers and operation teams. Container solutions allow building very flexible software infrastructures. Although lots of efforts have been devoted to enhancing containerization security, containerized environments still have a huge attack surface. Completely avoiding severe security issues have so far not be
Background: Cognitive functioning may have implications for engagement in daily occupations among people with schizophrenia.Objectives: This cross-sectional study explores relationships between time use assessed occupational engagement and cognitive functioning among persons with schizophrenia.Methods: Thirty-nine participants from four mental health care services in Sweden participated. The Profi
The spontaneous open-field behavioural effects of 10 days of chronic treatment with two clinical doses (10 and 20 mg/kg daily) and one high/toxic dose (100 mg/kg daily) of the selective serotonin reuptake inhibitor citalopram (delivered subcutaneously by implanted osmotic pumps) were examined in rats. Central and peripheral arena locomotor and rearing activities were recorded simultaneously, and t
Cancer is one of the leading causes of death globally. Novel therapeutics is urgently needed to advance treatment, especially for generalized disease where current treatment options have a poor prognosis. In particular, targeted therapy that can address genetic changes would be of great value. RNA interference is an evolutionary conserved gene regulatory mechanism that can be used by introducing e
This study discusses IKEA's brand storytelling across its official websites and Chinese social media platforms, with a focus on the balance between consistency and localisation in its brand narratives on the Swedish and Chinese official websites, as well as the expression of local adaptation in the brand's official accounts on Xiaohongshu and Weibo. Through multimodal social semiotic analy
China employs approximately half of the world's coal workers while also implementing one of the world's largest decarbonization programs. This thesis examines how official policy discourse constructs the social costs of coal transition, focusing on how coal workers and transition-related burdens are framed, recognized, and governed in official policy texts. The study uses Critical Discours
The aim of this study is to bring further understanding to the contested relationship between development aid and democracy. By introducing quality of democracy as an alternate measure to the ones previously used, the ambition is to approach the subject from a new perspective. In this thesis, the following research question will be answered: To what extent does Official Development Assistance (ODA
