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Loneliness in advanced age has become one of the societal concerns considering its detrimental effects on physical and mental health of older people. Information and communication technologies show the potential to prevent or tackle loneliness and social isolation among older people. Given a percentage of the older population feeling lonely, loneliness in older age has been increasingly recognized
The purpose of this study is to investigate the prediction of Ki-67 expression of breast cancers using MRI parameters from ultrafast (UF) DCE-MRI, DWI, T2WI, and the lesion size. Breast MRI was performed with a 3T scanner using dedicated breast coils. UF DCE-MRI was obtained using Compressed Sensing-VIBE (prototype sequence). As a kinetic parameter of UF DCE-MRI, maximum slope (MS) was defined as
This chapter provides overview of fundamental definitions, tools and new methods towards improved channel modeling reported in the Co-operation in Science and Technology (COST)-Inclusive Radio Communications (IRACON) Action for future wireless communications and networks. The overview first covers definitions of propagation environments as they determine most relevant propagation mechanisms to con
When conducting randomised clinical trials, the choice of methodology and statistical analyses will influence the results. If the planned methodology is not of optimal quality and predefined in detail, there is a risk of biased trial results and interpretation. Even though clinical trial methodology is already at a very high standard, there are many trials that deliver biased results due to the im
Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used single-nuclei RNA sequencing (snRNA-seq) to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening TBI. This revealed a un
Background: Family is a crucial social institution in end-of-life care. Family caregivers are encouraged to take on more responsibility at different times during the illness, providing personal and medical care. Unpaid work can be overburdening, with women often spending more time in care work than men. Objectives: This study explored multiple views on the family’s role in end-of-life care from a
Importance: Blood phosphorylated tau (p-tau) and amyloid-β peptides (Aβ) are promising peripheral biomarkers of Alzheimer disease (AD) pathology. However, their potential alterations due to alternative mechanisms, such as hypoxia in patients resuscitated from cardiac arrest, are not known. Objective: To evaluate whether the levels and trajectories of blood p-tau, Aβ42, and Aβ40 following cardiac a
Professor Carita Paradis, Centre for Languages and Literature, Lund University 1 Conferences Plenaries and invited lectures 2025 2023 2022 2022 2021 2021 2021 2020 2020 2019 2019 2018 2017 2015 2015 2015 2014 2014 Invited speaker at the University of Macerata (3 June) with Sara Farshchi “Good and bad opposition and the scope of creative potential”. Invited speaker at the University of Florence (20
https://www.sol.lu.se/media/documents/persons/CaritaParadis/Conferences_20.pdf - 2026-05-14
This project explores how a beginner friendly music production device can lower the threshold for engaging with sound creation and rhythm making. Many existing tools rely on prior knowledge or technical skill, which discourages new users from experimenting in creative ways. This project instead focuses on quick feedback, clear interaction and a tactile experience that invites curiosity and play. T
Background: Previous studies support a tumor-suppressor role for LRRC3B across various types of cancers. We aimed to investigate the association between DNA methylation of LRRC3B and overall survival (OS) for patients with early-stage non-small cell lung cancer (NSCLC).Methods: This study included 1,230 patients with early-stage NSCLC. DNA was extracted from lung tumor tissues and DNA methylation
Background: The clinical importance of immediate coronary angiography, with potentially subsequent percutaneous coronary intervention (PCI), in out-of-hospital cardiac arrest (OHCA) patients without ST-elevation on the ECG is unclear. In this study, we assessed feasibility and safety aspects of performing immediate coronary angiography in a pre-specified pilot phase of the ‘DIrect or Subacute Coro
Objective: To explore associations between four methods assessing long-term neurocognitive outcome after out-of-hospital cardiac arrest and early hypoxic-ischemic neuronal brain injury assessed by the biomarker serum neurofilament light (NFL), and to compare the agreement for the outcome methods. Methods: An explorative post-hoc study was conducted on survivor data from the international Target Te
Background: Selective water uptake by neurons and glial cells and subsequent brain tissue oedema are key pathophysiological processes of hypoxic-ischemic encephalopathy (HIE) after cardiac arrest (CA). Although brain computed tomography (CT) is widely used to assess the severity of HIE, changes of brain radiodensity over time have not been investigated. These could be used to quantify regional bra
INTRODUCTION: Endovascular thrombectomy (EVT) is a significant improvement in the care of acute ischemic stroke (AIS) patients, but only a small portion of patients receive treatment. Our aim was to analyze EVT implementation in Sweden according to a set of key performance indicators (KPIs) for procedural and implementational effectiveness. METHODS: A nationwide prospective registry-based observ
Semi-supervised learning (SSL) uses unlabeled data during training to learn better models. Previous studies on SSL for medical image segmentation focused mostly on improving model generalization to unseen data. In some applications, however, our primary interest is not generalization but to obtain optimal predictions on a specific unlabeled database that is fully available during model development
PURPOSE: Despite impressive response rates following adoptive transfer of autologous tumor-infiltrating lymphocytes (TILs) in patients with metastatic melanoma, improvement is needed to increase the efficacy and broaden the applicability of this treatment. We evaluated the use of vemurafenib, a small-molecule BRAF inhibitor with immunomodulatory properties, as priming before TIL harvest and adopti
Ett patent är en immateriell rättighet som medför en ensamrätt för patenthavaren att dra affärsmässig nytta av en viss uppfinning under en begränsad tidsperiod. Den som kränker patenthavarens ensamrätt gör sig skyldig till patentintrång. Vid patentintrång tillhandahåller den svenska patentlagen (1967:837) ett antal olika sanktionsmöjligheter. De primära civilrättsliga sanktionsformerna utgörs av pA patent is a kind of intellectual property right that grants the patent holder an exclusive right to profit from a certain invention for a limited time period. Anyone who violates the patent holder's exclusive right is guilty of patent infringement. In cases of patent infringement the Swedish Patent Act (patentlag 1967: 837) provides a number of different sanction options. The primary civil s
Aim: Periodontitis proxy variables enable an expansion of periodontal research. The study aimed to estimate the validity of questionnaire items and registry data in relation to Stage III–IV periodontitis and having 50% bone loss. Methods: Malmö Offspring Dental Study (MODS) participants (995) filled out questionnaires and underwent periodontal and panoramic radiography examinations. The questionna
Background: Fine-needle aspiration biopsy (FNAB) of lymph nodes is a widely used method for evaluating lymphadenopathy. FNAB offers general advantages of rapid turnaround time, low cost and minimal morbidity, and more specific advantages in various clinical situations, such as deeply located lymph nodes or patients with significant comorbidities. The FNAB sample can be utilized for a wide range of
