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Non-lethal infections are common in free-living animals and the associated sickness behaviours can impact crucial life-history trade-offs. However, little is known about the duration and extent of such sickness behaviours in free-living animals, and consequently how they affect life-history decisions. Here, free-living Eurasian blackbirds, Turdus merula, were immune-challenged with lipopolysacchar
Monitoring insects of different species to understand the factors affecting their diversity and decline is a major challenge. Laser remote sensing and spectroscopy offer promising novel solutions to this. Coherent scattering from thin wing membranes also known as wing interference patterns (WIPs) have recently been demonstrated to be species specific. The colors of WIPs arise due to unique fringy
Current techniques for visualising geospatial Linked Data are limited in terms of multiple representation, which has been studied for decades by cartographers and considered as a prerequisite for deriving appropriate geovisualisation applications. In order to alleviate this issue, this paper presents a work in progress, in which the multiple representation geospatial data are released as Linked Da
Aim: Many pediatric cancer patients undergo repeated bone marrow aspirations (BMAs) for diagnostic and treatment evaluation purposes. Full anesthesia is the standard of care during this procedure in high-income countries. At hospitals with low resources in low/middle-income countries many children undergo these painful procedures without sufficient pain relief. This study aimed to evaluate the use
Den här artikeln granskar subskriptionerne på Markusevangeliet i 157 grekiska handskrifter, och noterar deras gradvisa utveckling från att vara identisk med titeln i den tidigaste fasen till att bli mer och mer utarbetad och betydelsefull för tolkningshistorien. Tidigt, vilket återspeglas i titeln, förknippades det andra evangeliet med Markus, känd för att vara Petrus lärjunge och tolk. Under det This article surveys the subscriptions to the Gospel of Mark in 157 Greek manuscripts, noting their gradual development from being identical to the title in the earliest phase to becoming more and more elaborate and significant for the history of interpretation. Early on, as reflected in the title, the Second Gospel was associated with Mark, known to be Peter’s disciple and interpreter. In the fou
Science originates knowledge and downstream innovation. “Big” science is likely to, along the line, give rise to “big” innovation. Large research infrastructures are characterized by containing a large number of partners involved in complex networks of internal and external collaborations. This chapter explores how large research infrastructures (broadly defined) manage internally and externally t
A novel photodynamic therapy system based on interstitial illumination using multiple fibres is under development. The aim with this system is to enable treatment of large tumour volumes and also to utilise real-time measurements to allow on-line dosimetry. Important dosimetric parameters to measure are light fluence rate, sensitizer fluorescence intensity and local blood oxygenation. A constructi
The ATLAS experiment at the Large Hadron Collider has a broad physics programme ranging from precision measurements to direct searches for new particles and new interactions, requiring ever larger and ever more accurate datasets of simulated Monte Carlo events. Detector simulation with Geant4 is accurate but requires significant CPU resources. Over the past decade, ATLAS has developed and utilized
Background: Targeted therapeutic mild hypercapnia may attenuate brain injury in comatose adults resuscitated from out-of-hospital cardiac arrest. Objective: To describe the study protocol and statistical analysis plan for the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial. Design, setting, participants and interventions: TAME is a phase 3, multicentre, paralle
Background: Posterior fossa tumours (PFT) are the most common childhood brain tumours, and children treated for these tumours are at increased risk of persistent speech, language and/or communication difficulties. Such difficulties have often been described in association with the postoperative complication cerebellar mutism syndrome (CMS), but can also occur in children without a period of mutism
Advanced instrumentation and versatile setups are needed for understanding light interaction with biological targets. Such instruments include (1) microscopes and 3D scanners for detailed spatial analysis, (2) spectral instruments for deducing molecular composition, (3) polarimeters for assessing structural properties, and (4) goniometers probing the scattering phase function of, e.g., tissue slab
Significant efforts are ongoing to develop refined differentiation protocols to generate midbrain dopamine (DA) neurons from pluripotent stem cells (PSCs) for application in disease modeling, diagnostics, drug screening, and cell-based therapies for Parkinson's Disease (PD). An increased understanding of the timing and molecular mechanisms promoting the generation of distinct subtypes of human mid
Topic-independent expressions for conveying agreement and disagreement were annotated in a corpus of web forum debates, in order to evaluate a classifier trained to detect these two categories. Among the 175 expressions annotated in the evaluation set, 163 were unique, which shows that there is large variation in expressions used. This variation might be one of the reasons why the task of automati
INTRODUCTION: Many depressed patients do not achieve remission with available treatments. Anhedonia is a common residual symptom associated with treatment resistance as well as low function and quality of life. There are currently no specific and effective treatments for anhedonia. Some trials have shown that dopamine agonist pramipexole is efficacious for treating depression, but more data is nee
Extreme ultraviolet (XUV) laser radiation is commonly produced via high-harmonic generation (HHG) in gases. The lasers that drive this process typically operate at low pulse repetition rates (<100 kHz). Under these operating conditions, the plasma generated by each laser pulse clears the generation volume before the next pulse arrives. Therefore, each laser pulse interacts with fresh plasma-free g
Antibody microarray is a novel technology with great promise within proteomics. Intense work is under way to evolve this methodology into the high-throughput proteomic research tool needed by the research community. Despite recent advances, there is a growing need for additional highperformance substrates for antibody microarrays as well as for protein arrays in general. In this study, we have suc
Chronic inflammation may be involved in combat-related post-traumatic stress disorder (PTSD) and may help explain comorbid physical diseases. However, the extent to which combat exposure per se, depression, or early life trauma, all of which are associated with combat PTSD, may confound the relationship between PTSD and inflammation is unclear.
In this paper we report upon some results of an empirical study involving employees from 32 SMEs in the UK on how they approach socio-technical principles in the design of their work systems. We are particularly interested in what extent employees are engaged with decision making, change in work practices and job satisfaction. Our findings reveal that employees would prefer more responsibilities,
This paper describes the results of the conceptual and practical strategy work performed by the Swedish Ergonomics and Human Factors Society (EHSS) today. The rationale of EHSS is to strengthen the quality of ergonomics/human factors knowledge and practice in Sweden and form a multidisciplinary platform across disciplines and professions for collaboration and for knowledge sharing. EHSS gathers ab
Background: Individualized cancer rehabilitation should be an integral part of cancer care. Contact nurses play a key role in identifying patient needs and coordinating evidence-based interventions to support rehabilitation. However, cancer rehabilitation remains marginal in current practice, as contact nurses face challenges due to the lack of systematic processes for assessment, intervention, an
