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Exposure to urban air pollution during early pregnancy is associated with increased risk for adverse pregnancy outcomes, such as preeclampsia (PE), and there is an urgent need to understand how air pollution affects biological mechanisms in the placenta. Hofbauer cells (HBCs) are fetal placental macrophages that regulate immune tolerance in the placenta. They are normally polarized towards an anti

Background: Physiologically guided revascularization improves clinical outcomes. The cutoff values for deferral with fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are the same across all coronary arteries, despite differences in coronary flow patterns. The objective was to compare deferral rates using either FFR or iFR in the right coronary artery (RCA), left anterior desce

Background: Previous studies suggest an antidepressant effect of omega-3 fatty acids (n-3 PUFAs). This effect may be larger in patients with low-grade inflammation, defined as mild elevations of high sensitivity C-reactive protein or other commonly used inflammatory markers. The antidepressant mechanisms of n-3 PUFAs are not fully understood but may involve modulation of immunometabolic processes

We have used approximately 40 fs pulses from a Ti:sapphire laser to investigate the ultrafast energy transfer and relaxation dynamics in the light-harvesting pigment-proteins of photosynthetic purple bacteria. Our results reveal two new features, not earlier observed in light-harvesting pigments: (1) ultrafast relaxation characterized by a time constant of approximately 20 fs, which we interpret a

Artificiell intelligens har under de senaste åren fått en allt större betydelse inom hälso- och sjukvården. En framväxande tillämpning är AI-verktyg för journalföring, som automatiserar delar av det administrativa arbetet genom att omvandla tal till text, strukturera anteckningar och i vissa fall föreslå diagnoser eller remisser. Verktygen kan effektivisera vårdpersonalens arbete, men väcker samtiIn recent years, artificial intelligence has gained increasing importance within the healthcare sector. One emerging application is AI medical scribes, which automate parts of administrative work by converting speech to text, structuring clinical notes, and in some cases suggesting diagnoses or referrals. These tools have the potential to improve the efficiency of healthcare professionals, but at

Additive manufacturing (AM), which was first applied for rapid prototyping, is now becoming a real option for small-batch production of final products. Further expansion of AM is closely correlated to production costs. AM can only become competitive to traditional manufacturing methods if a product is designed for AM already from the beginning as it is an expensive technology that should only be a

In addition to a rise in global air and water mean temperatures, extreme climate events such as heat waves are increasing in frequency, intensity, and duration in many regions of the globe. Developing a mechanistic understanding of the impacts of heat waves on key ecosystem processes and how they differ from just an increase in mean temperatures is therefore of utmost importance for adaptive manag

Lung cancer (LC) generally lacks unique core symptoms or signs. However, there are a multitude of bodily sensations that are often non-specific, not easily understood, and many times initially not recognized as indicative of LC by the affected person, which often leads to late diagnosis. In this international qualitative study, we inductively analyzed retrospective accounts of 61 people diagnosed

Background: Chronic breathlessness adversely impacts people with chronic obstructive pulmonary disease and their caregivers (family and friends), who may, in turn, experience significant burden due to their caregiving role. Sustained-release morphine may reduce chronic breathlessness in some patients, which may have an impact on caregivers’ perceived burden. Aim: To explore the impact on caregiver

Objectives: To identify characteristics of older adult emergency department (ED) patients aged ≥65 with suicidal ideation and/or behavior. Methods: A single center retrospective chart review analyzed 392 patients (≥65) with suicidal ideation and/or behavior (2013–2019). Comprehensive full-text searches were used. Subgroup analyses for age and gender were conducted. Results: Depressive disorder was

BACKGROUND: Preeclampsia is a hypertensive pregnancy disorder marked by endothelial damage. Healthy endothelium is covered by a protective glycocalyx layer, which, when degraded, releases detectable products into the blood. Sphingosine-1phosphate (S1P) is a cardiovascular biomarker involved in glycocalyx preservation, linked to placentation and preeclampsia development. The study aimed to test the

Background: The drive for home care has increasingly impacted the organization and allocation of resources within the Swedish healthcare system. Objectives: With an interest in uncovering prerequisites for palliative care, this study aimed to investigate longitudinal trends in place of death within the adult Swedish population from 2013 to 2019 and examine potential associations between place of d

Background In adults with serious respiratory illness, breathlessness is prevalent and associated with reduced health-related quality of life. The aim of this review was to assess the impact of breathing techniques on breathlessness in adults with serious respiratory illness. Methods Electronic databases were searched to identify randomised controlled trials testing breathing techniques (technique

Background: Percutaneous coronary intervention (PCI) of saphenous vein grafts (SVG) is associated with poor outcomes and is often regarded as inferior to native vessel PCI. We investigated clinical outcomes of SVG-PCI using contemporary drug-eluting stents (DES), in a complete, nationwide population. Methods: The complete Swedish Coronary Angiography and Angioplasty Registry (SCAAR) was used to id

BackgroundCritical COVID-19 is associated with high mortality, and acute kidney injury (AKI) is common. Endostatin has emerged as a promising prognostic biomarker for predicting AKI and mortality in intensive care. This study aimed to investigate plasma endostatin at intensive care unit (ICU) admission as a biomarker for AKI, renal replacement therapy (RRT), and 90-day mortality in COVID-19.Method

Background: Acute kidney injury (AKI) is a serious complication of out-of-hospital cardiac arrest (OHCA). Post-resuscitation cardiogenic shock (CS) is a key contributing factor. Targeting a higher arterial carbon dioxide tension may affect AKI after OHCA in patients with or without CS. Methods: Pre-planned exploratory study of a multi-national randomised trial comparing targeted mild hypercapnia o

Background: Hosts are often simultaneously infected with several parasite species. These co-infections can lead to within-host interactions of parasites, including mutualism and competition, which may affect both virulence and transmission. Birds are frequently co-infected with different haemosporidian parasites, but very little is known about if and how these parasites interact in natural host po