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Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model, we demonstrate that FLT3 ITD, FLT3 N676K, and NRAS G12D accelerate KMT2A-MLLT3 leukemia onset. Further, also subclonal FLT3 N676K mutations accelerate

BACKGROUND: A key component of achieving universal health coverage is ensuring that all populations have access to quality health care. Examining where gains have occurred or progress has faltered across and within countries is crucial to guiding decisions and strategies for future improvement. We used the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) to assess person

Popular Abstract in Swedish Ökad förståelse för hjärtats pumpfunktion är av stort intresse för att kunna förbättra diagnostik, behandling och prognoser för hjärtsjuka patienter. Blodflöde i hjärtat är direkt kopplat till hjärtats form och rörelse och kan därför vara en viktig markör för hjärtats funktion. Därför var målet med denna avhandling att utveckla och förbättra mätningar av blodflöde med hIncreased understanding of the pumping mechanics of the heart are of great importance to develop diagnostics, treatment and prognostics for cardiovascular diseases. Blood flow in the heart is connected to its anatomy and function, and may therefore be a sensitive marker of cardiac health and disease. Therefore, the aim of this thesis is to develop and validate methods for quantification and visual

Aim To investigate public health nurses' perceptions and experiences of mental health and of the prevention of mental ill health among women postpartum, within paediatric healthcare services.

Popular Abstract in Swedish Denne afhandling vedrører geriatriske patienters ernæringsproblemer indenfor rammen af geriatrisk rehabilitering. Geriatriske patienter er svækkede ældre mennesker, der er præget af aldring og kronisk sygdom. Den hændelse som er årsag til indlæggelse er ofte som toppen af et isbjerg, hvor der kan ligge mange andre problemer gemt under vandoverfladen. En lungebetændelse The aim was to evaluate the effectiveness and feasibility of functional and nutritional assessments in geriatric rehabilitation in Copenhagen, Denmark, and in addition to study clinically identifiable risk factors for undernutrition, association between nutritional and ADL status, feasibility and effectiveness of nutritional intervention conducted by the nursing staff, and the nursing staffs attit

This paper evaluates the cost-effectiveness of renovating single-family houses to Passive House level, as compared to maintaining the existing buildings or renovating to building regulation level. The assessment involved life cycle cost analyses, and concerns the Swedish single-family housing stock constructed between 1961 and 1980, which accounts for about a third of Sweden’s two million single-f

Denna debattartikel argumenterar för att socialt arbete och socialtjänst behöver utvecklas i förhållande till digitalisering. Som ett led i ett samarbetsprojekt mellan Lunds universitet och Helsingborg stad, finansierat av både Vinnova och Helsingborg stad, skriver företrädare för både universitet och stad en debattartikel i DN. Hur kan socialtjänsten utvecklas med hjälp av digitalisering - nu och

In the US, whistle blowers who help uncover illegal offlabel promotion are usually awarded 15-25 percent of any recovered damages. Does incentivizing informants deter off-label drug marketing – and should other countries follow suit?

Det är idag vanligt förekommande att företag nyttjar en så kallad cause branding strategy för att marknadsföra sina produkter. Detta gynnar ofta både försäljningen och bilden konsumenterna får av företaget (Persis Murray, 2012, s. 84). Cause branding strategies har utvecklats och förekommer idag genom olika metoder, så kallad varuaktivism. Denna uppsats syftar till att undersöka feministisk varuak

This study analyses the constitutive power of narratives in relation to a retroliberal paradigm shift in EU development policy by focusing on blended finance targeting sub-Saharan Africa. This study builds on the claims of Mawdsley (2015) that a reconfiguration of global development policy has challenged the North ontologically, which have been accompanied with the emergence of retroliberalism. Th

Sedan urminnes tider har frågor om etik och moral haft stor inverkan på människors liv. I den globaliserade och digitala värld vi idag lever i är dessa fortfarande aktuella, men har kommit att förändras. Då vi har gått från att befinna oss i en kollektiv till en konnektiv kontext, och vår kommunikation inte längre enbart sker ansikte mot ansikte, har nya etiska och moraliska frågor uppkommit. Den

This thesis investigates the trends of subnational economic development in Vietnam from 2018 to 2023 to test for economic convergence on a regional scale in addition to analysing the extent to which local institutions lead to differing economic outcomes. The findings of this paper suggests that there existed a wide gap in the economic performance of Vietnamese provinces at the start of the period

We present the artillery of a well-preserved late medieval Danish-Norwegian carvel warship, Gribshunden. Probably built in the Netherlands in 1484, the ship served King Hans until sinking in June 1495. Of its original 50 or more guns, elements of 11 have been recovered and digitally recreated, and more remain on the wreck. Investigation of this site provides insights into the development of shipboWe present the artillery of a well-preserved late medieval Danish-Norwegian carvel warship, Gribshunden. Probably built in the Netherlands in 1484, the ship served King Hans until sinking in June 1495. Of its original 50 or more guns, elements of 11 have been recovered and digitally recreated, and more remain on the wreck. Investigation of this site provides insights into the development of shipbo

This study explores socioeconomic disparities in how patients trade off quality against other features when choosing their primary care provider. We use a unique registry dataset linking the choices of individuals who recently moved to a new market, and therefore need to select a new provider, with detailed individual-level measures of socioeconomic status (SES) and provider-level measures of pati

In a new report, the Swedish Institute for Health Economics (IHE) compares the cancer situation in EU28 plus Norway and Switzerland. The report builds on a previous comparative study conducted in 2005 and provides a comprehensive view of the development of cancer in Europe over the past two decades. The report shows that the number of people diagnosed with cancer continue to increase in Europe, up

Independence and collaboration both play crucial roles in PhD students’ research practice and in their socialization into the PhD role. This study examines how theexpectation of PhD students' academic independence intersects with the need for more collaborative engagements within research groups. Drawing on interviews with supervisors and an analysis of co-authorship patterns in PhD studentdissert