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Background/purpose: The objective of this study was to explore the impact of systemic lupuserythematosus and belimumab given in addition to standard of care therapy on 13-valentconjugated pneumococcal vaccine (PCV13) response. Methods: Forty-seven systemic lupuserythematosus patients and 21 healthy controls were immunized with a single dose of13-valent conjugated pneumococcal vaccine. Forty system

Urak Lawoi är en ursprungsbefolkning i Andamansjön som bl.a. bor på kända turistöar som Phuket, Phi Phi, Ko Lanta Yai och Ko Lipe utanför Thailands västkust. Deras språk och kultur skiljer sig från övriga thailändares, inte minst ifråga om kunskap att navigera på havet. Att bo på eller vid havet är centralt för deras identitet; det är där de fiskar, samlar föda på stränder och utför sina ritualer.On 26 December 2004, the Urak Lawoi sea people were hit by a huge tsunami that overwhelmed all of Southeast Asia causing the deaths of more than 350,000 people across the region. If the tsunami was the disaster, the “first wave”, the relief efforts and the assistance that came with it became the “second wave”, due to the social and economic changes that followed. The Urak Lawoi have for centuries,

Diamond-Blackfan anemia is a congenital erythroid hypoplasia and is associated with physical malformations and a predisposition to cancer. Twenty-five percent of patients with Diamond-Blackfan anemia have mutations in a gene encoding ribosomal protein S19 (RPS19). Through overexpression of RPS19 using a lentiviral vector with the spleen focus-forming virus promoter, we demonstrated that the Diamon

How might systems integration be furthered in healthcare? The paper addresses this by exploring critically the potentials of appreciative inquiry for accelerating systems integration through a large group intervention. We analyze a one-day dialog workshop to get “the whole system in the room” to improve cancer care in a regional health authority in south west Sweden. Seeing systems integration as

DEBATT. Om konsumenters data och tillit; om behov av kunskap, kompetens och kritisk blick för det datadrivna; och om behovet av att sticka hål på universitetens silos.

Conditional knockout mice are commonly used to study the function of specific genes in hematopoiesis. Different promoters that drive Cre expression have been utilized, with the interferon-inducible Mx1-Cre still being the most commonly used “deleter strain” in experimental hematology. However, different pitfalls associated with this system could lead to misinterpretation in functional studies. We

Even though leukemia is considered to be confined to one specific hematopoietic cell type, cases of acute leukemia of ambiguous lineage and patients relapsing in phenotypically altered disease suggest that a malignant state may be transferred between lineages. Because B-cell leukemia is associated with mutations in transcription factors of importance for stable preservation of lineage identity, we

PURPOSE: Leukemic stem cells (LSCs) may harbor important resistance to tyrosine kinase inhibitors in chronic myeloid leukemia (CML). We identified Philadelphia chromosome (Ph) positive CD34+CD38- bone marrow cells (here denoted LSCs) and addressed their response-predictive value in CML patients (n=48) subjected to nilotinib in the ENEST1st trial (NCT01061177).EXPERIMENTAL DESIGN: Two flow cytometr

Haemophilia is a congenital disorder with bleeding episodes as its primary symptom. These episodes can result in negative outcomes including joint damage, loss of active days due to hospitalization and reduced quality of life. Effective treatment, however, can improve the outcome. Registries have been used as a valuable source of information regarding the monitoring of treatment and outcome. The t

Den här fallstudien undersöker hur Rädda Barnen arbetar opinionsbildande i sin kampanj för att få hem de svenska barnen med föräldrar som har IS-kopplingar från Syrien. Studien har gjorts i syfte att få förståelse för hur Rädda Barnen använder sig av medier för att bedriva sitt kampanjarbete och sätta sig själva och de frågor de bedriver på agendan. Vi har genomfört en studie där vi analyserat fle

Bygg- och fastighetssektorn är en av de sektorer som släpper ut mest växthusgaser. Under ett enskilt år så svarar byggbranschen för utsläpp av växthusgaser på 21 miljoner ton koldioxidekvivalenter, vilket motsvarar 21 procent av Sveriges totala utsläpp. Av det totala utsläppet på 21 miljoner koldioxidekvivalenter så kommer 12,8 miljoner ton från inhemska utsläpp av växthusgaser och 8,2 miljoner toThe building and real estate sector is one of the sectors that emits the most greenhouse gases. For a single year, the construction industry is responsible for greenhouse gas emissions of 21 million tons of carbon dioxide equivalent, which corresponds to 21 per cent of Sweden's total emissions. Of the total emissions of 21 million carbon dioxide equivalents, 12.8 million tons come from domesti

Byggbranschen är i dagsläget en av de störst bidragande faktorerna till utsläpp av fossila bränslen i Sverige och besitter en stor utvecklingspotential beträffande reducering av klimatpåverkan. En byggnads klimatpåverkan under en livscykel kan beräknas genom metoden livscykelanalys, som inkluderar en produkts, eller i detta fall en byggnads, klimatpåverkan från råvaruutvinning till avfallshanterinThe construction industry is currently one of the largest contributing sources to carbon dioxide emissions in Sweden and has great development potential in reducing its climate impact. Since January 2022, the Swedish government requires a declaration of the climate impact of each recently constructed building. To calculate the climate impact of a building, the life cycle assessment tool is used, a

Among different lipid nanoparticle systems, sponge-phase nanoparticles (SPNPs) have recently attracted interest due to their ability to encapsulate large macromolecules along with demonstrated high interfacial activity. The potential application of SPNPs calls for investigations into how buffer conditions affect SPNP structure and interfacial activity. Herein, we systematically investigated how di

Hypothesis: Sponge phase (L3) lipid nanoparticles (L3-NPs) have been shown to have large potential for the encapsulation of biomolecules, such as enzymes, with applications in food and pharmaceutical science. In this study, we introduce new formulations of L3-NPs including the phospholipids dioleoylphosphatidylcholine (DOPC) and dioleoyltrimethylammonium propane (DOTAP). The interaction of these n

Mutations resulting in constitutive activation of signaling pathways that regulate ribosome biogenesis are among the most common genetic events in acute myeloid leukemia (AML). However, whether ribosome biogenesis presents as a therapeutic target to treat AML remains unexplored. Perturbations in ribosome biogenesis trigger the 5S ribonucleoprotein particle (RNP)–Mdm2–p53 ribosomal stress pathway,

Background: Induced hypothermia after cardiac arrest is neuroprotective in several animal models of cardiac arrest, but few high-quality studies have been conducted in larger animals. Recent clinical trials have questioned the beneficial effects of post-ischemic hypothermia. This study investigated whether immediate cooling or a 2-h delay in cooling to 33 °C after cardiac arrest was neuroprotectiv

The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI-insensitive leukemia stem cells (LSCs) persist in most patients even after years of treatment and are imperative for disease progression as well as recurrence during treatment-free remission (TFR). Here, we have generated high-resolut

Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. Here, we characterized tumor-associated foam cells (TAFs), a type of lipid droplet-loaded macrophage, in human glioblastoma. Through extensive analyses of patient tumors, together with in vitro and in vivo investigations, we found that TAFs exhibit distinct protumorigenic characteristics related to hypox