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Familial clustering of venous thromboembolism (VTE) was described as far back as 1905 by Briggs. Although Egeberg discovered inherited deficiency of antithrombin in 1965, it was not until Dahlbäck discovered resistance to activated protein C in 1993 that it became clear that genetic factors are common risk factors of VTE. Several genes have been linked to familial aggregation of VTE and genome-wid
print_courseplan.php KURSPLAN Institutionen för hälsovetenskap Kurskod VMD903 Vetenskapliga metoder med inriktning vård av äldre, 7.5 högskolepoäng Philosophy of Science and research methods in elderly care, 7.5 HE credits Fastställandedatum 2009-09-30 Utbildningsnivå Avancerad nivå Reviderad senast 2016-01-19 Beslutande UN Gäller från H16 Kursens mål Efter genomgången kurs skall studenten: Kunska
https://www.student.med.lu.se/sites/student.med.lu.se/files/kursplan-vetenskaplig-metod-inriktning-vard-av-aldre.pdf - 2026-06-01
Cell type annotation remains a critical bottleneck, with current methods often inaccurate and requiring extensive manual validation, particularly in disease contexts. While large language models (LLMs) show promise, they can be unreliable due to hallucinations. We developed CyteType, a multi-agent framework that generates competing hypotheses grounded in full expression data and study context, val
The BCR::ABL1 tyrosine kinase inhibitors (TKIs) in CML represent a paradigm for molecularly targeted therapy. However, clinical outcomes - rate/depth of response, treatment-free remission (TFR), progression to blast crisis (BC) - and adverse events vary among patients. While additional somatic mutations have been invoked to explain varying clinical outcomes, we here propose a complementary perspec
The genetic contributions to early onset heart failure (HF) are incompletely understood. Genetic testing in advanced HF patients undergoing heart transplantation (HTx) may yield clinical benefits, but data is limited. We performed deep-coverage whole genome sequencing (WGS) in 102 Swedish HTx recipients. Gene lists were compiled through a systematic literature review. Variants were prioritized for
Several studies have shown that the family history of venous thromboembolism (FHVTE) is a predictor of first venous thromboembolism (VTE). However its role in recurrent VTE is still controversial.
Studies of circular DNA confined to nanofluidic channels are relevant both from a fundamental polymer-physics perspective and due to the importance of circular DNA molecules in vivo. We here observe the unfolding of confined DNA from the circular to linear configuration as a light-induced double-strand break occurs, characterize the dynamics, and compare the equilibrium conformational statistics o
The intensive use of nano-sized titanium dioxide (TiO2) particles in many different applications necessitates studies on their risk assessment as there are still open questions on their safe handling and utilization. For reliable risk assessment, the interaction of TiO2 nanoparticles (NP) with biological systems ideally needs to be investigated using physico-chemically uniform and well-characteriz
Prediction of recurrence in patients with unprovoked venous thromboembolism (VTE) remains a challenge. Studies of atherosclerosis suggest a protective role of transforming growth factor (TGF)-β. However, the role of TGF-β has not been studied in VTE. The aim of this study was to investigate TGF-β as a predictive marker of recurrent VTE in patients with a first episode of unprovoked VTE. Patients i
There are two matters, which have important impacts on development of the international intellectual property rights (IPRs). The first is the significant economic importance of the IPRs and its large share in international trade and the second is the protection of IPRs especially in developing and importing countries. More than two thirds of the WTO members are developing countries (DCs) and they
Syftet med denna uppsats var att undersöka huruvida ett nationalekonomiskt perspektiv, genom kostnads-intäktsanalys, kan bidra till att bredda diskussionen om Kriminalvården och dess effektiviseringsarbete. De mått som idag används för att beskriva fångvårdens effektivitet utgörs av bl.a. återfallsbrottslighet, påbörjade samt avslutade behandlingsprogram och antalet rymningar från anstalt. Ingen e
When double-stranded DNA molecules are heated, or exposed to denaturing agents, the two strands are separated. The statistical physics of this process has a long history and is commonly described in terms of the Poland-Scheraga (PS) model. Crucial to this model is the configurational entropy for a melted region (compared to the entropy of an intact region of the same size), quantified by the loop
While cognitive ability is inversely associated with risk for schizophrenia (SZ), the association is less clear with other nonaffective psychoses (ONAP) and bipolar illness (BPI). Using national Swedish hospital registry data, we examined the prospective relationship between school achievement (SA) and development of SZ, ONAP, and BPI in 1800643 adolescents born 1972-1990. We used Cox proportional
The extension of DNA confined to nanochannels has been studied intensively and in detail. However, quantitative comparisons between experiments and model calculations are difficult because most theoretical predictions involve undetermined prefactors, and because the model parameters (contour length, Kuhn length, effective width) are difficult to compute reliably, leading to substantial uncertainti
Particle size distributions and hygroscopic growth were studied in a town in Sweden with extensive emissions from wood combustion. The average deposited fraction of particle number, surface area and volume dose in the human respiratory tract was estimated using the data set, as well as the typical deposition pattern of the two dominant particle source types: wood combustion and traffic exhaust. As
Particulate air pollution increases risk of cancer and cardiopulmonary disease, partly through oxidative stress. Traffic-related noise increases risk of cardiovascular disease and may cause oxidative stress. In this controlled random sequence study, 18 healthy subjects were exposed for 3h to diesel exhaust (DE) at 276μg/m(3) from a passenger car or filtered air, with co-exposure to traffic noise a
The ability of particles to activate and form cloud droplets influences the functioning of the Earth's hydrological cycle. This work links the particle water uptake at subsaturation to the critical supersaturation ratio needed for particles to become cloud condensation nuclei (CCN). Five models using the particle hygroscopic growth at subsaturation for predicting the critical supersaturation neede
