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PURPOSE: Adjuvant chemotherapy versus observation and chemotherapy at progression was evaluated in 162 patients in a prospective randomized multicenter study. We also evaluated DNA-measurements as an additional prognostic factor.PATIENTS AND METHODS: Patients received adjuvant carboplatin AUC 7 every 28 days for six courses (n = 81) or no adjuvant treatment (n = 81). Eligibility included surgicall

We investigate the impact of employment protection regulation on firms’ reluctance to apply for bank finance (loans and overdrafts). Our findings reveal that longer notice periods reduce the likelihood that firms are discouraged from applying for bank finance in the case of blue-collar workers, but they increase it in the case of white-collar workers. Our interpretation is that, in the case of blu

BACKGROUND: Pancreatic cancer presents as advanced disease in >80% of patients; yet, appropriate ages to consider prevention and early detection strategies are poorly defined. We investigated age-specific associations and attributable risks of pancreatic cancer for established modifiable and non-modifiable risk factors.PATIENTS AND METHODS: We included 167 483 participants from two prospective US

Plants have developed complex molecular mechanisms to recognize and respond to the different microorganisms present in their surroundings. The most studied response mechanisms are plant defense responses. These defense response mechanisms share many similar components with the plant response mechanisms to beneficial microbes. Therefore, studying the defense response mechanisms against pathogens caPlants have developed complex molecular mechanisms to recognize and respond to the different microorganisms present in their surroundings. The most studied response mechanisms are plant defense responses. These defense response mechanisms share many similar components with the plant response mechanisms to beneficial microbes. Therefore, studying the defense response mechanisms against pathogens ca

This research project aims to explore and theorize the role of the Market in a hyperviolence-endorsing consumer culture. How does the subaltern speak through “gangfluencers” in a Global North welfare society, and how do affective intensities of consumer desire enact the violent consumer subject herein?This research project aims to explore and theorize the role of the Market in a hyperviolence-endorsing consumer culture. How does the subaltern speak through “gangfluencers” in a Global North welfare society, and how do affective intensities of consumer desire enact the violent consumer subject herein?

This article analyzes rational decision-making in court as an emotivecognitiveprocess formed in and through social interaction. Currenttheoretical perspectives have shown how emotion and thought areintertwined in the workings of the human brain but have seldom elaboratedon the contextual and structural features of rational-emotionaldecision-making. I propose a model that maps emotional processesanThis article analyzes rational decision-making in court as an emotivecognitiveprocess formed in and through social interaction. Currenttheoretical perspectives have shown how emotion and thought areintertwined in the workings of the human brain but have seldom elaboratedon the contextual and structural features of rational-emotionaldecision-making. I propose a model that maps emotional processesan

Primary graft dysfunction (PGD), defined as ventricular dysfunction occurring within 24 hours after heart transplantation (HTx) in the absence of identifiable secondary causes, remains a major contributor to early post-transplant mortality. Over the past decade, there has been a growing understanding of the burden of PGD, the clinical relevance of PGD classification and severity grading, and effor

Microsoft Word - protokoll BS 2020-02-17_final.docx Bibl iotekss tyre lsen Närvarande Ledamöter Bo-Anders Jönsson vicerektor, ordförande Heiko Herwald vicedekan, Medicinska fakulteten Erik Swietlicki vicedekan, Lunds tekniska högskola Barbara Törnkvist-Plewa prodekan, Humanistiska och teologiska fakulteterna Externa ledamöter Lars Burman överbibliotekarie, Uppsala universitet Catta Torhell överbib

https://www.lub.lu.se/internt/sites/lub.lu.se.internt/files/bilaga_17_protokoll_bs_2020-02-17_final.pdf - 2026-05-30

Fracture behavior of an ultra thin Aluminium foil was studied. For very short crack lengths, fracture has been followed in the scanner electronic microscope (SEM) with a tensile stage. A single edge notched tension specimen was used. Crack length and applied load during the crack growth were measured. These results have been used to calculate fracture strength using linear elastic fracture mechani

Background: Coronary heart disease (CHD) and myocardial infarction (MI) are associated with neighborhood-level socioeconomic status (SES). Statins are important drugs for secondary prevention of MI. However, no study has determined whether neighborhood-level SES is associated with statin medication in MI patients. We aimed to determine whether there is a difference in statin medication rate in MI

Extracellular vesicles (EVs) are derived from the membrane of platelets and released in the circulation upon activation or injury. Analogous to the parent cell, platelet derived EVs play an important role in hemostasis and immune responses by transfer of bioactive cargo from the parent cells. Platelet activation and release of EVs increases in several pathological inflammatory diseases, such as se

Bacterial extracellular vesicles (EVs) contain numerous active substances that mediate bacterial interactions with their host and with other microbes. Best defined are the EVs from Gram-negative bacteria that have been shown to deliver virulence factors, modulate the immune responses, mediate antibiotic resistance, and also inhibit competitive microbes. Due to the complex cell wall structures of G

Pulmonary delivery of small interfering RNA (siRNA) using nanoparticle-based delivery systems is promising for local treatment of respiratory diseases. We designed dry powder inhaler formulations of siRNA-loaded lipid-polymer hybrid nanoparticles (LPNs) with aerosolization properties optimized for inhalation therapy. Interactions between LPNs and pulmonary surfactant (PS) determine the fate of inh

Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukoc

Our goal was to test a cascade model to identify developmental pathways, or chains of risk, from neighborhood deprivation in childhood to alcohol use disorder (AUD) in young adulthood. Using Swedish general population data, we examined whether exposure to neighborhood deprivation during early and middle childhood was associated with indicators of social functioning in adolescence and emerging adul