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Inhibition of coxsackie B virus infection by soluble forms of its receptors: Binding affinities, altered particle formation, and competition with cellular receptors

We previously reported that soluble decay-accelerating factor (DAF) and coxsackievirus-adenovirus receptor (CAR) blocked coxsackievirus 133 (CVB3) myocarditis in mice, but only soluble CAR blocked CVB3-mediated pancreatitis. Here, we report that the in vitro mechanisms of viral inhibition by these soluble receptors also differ. Soluble DAF inhibited virus infection through the formation of reversi

Changes in resting-state functional connectivity after stroke in a mouse brain lacking extracellular matrix components

In the brain, focal ischemia results in a local region of cell death and disruption of both local and remote functional neuronal networks. Tissue reorganization following stroke can be limited by factors such as extracellular matrix (ECM) molecules that prevent neuronal growth and synaptic plasticity. The brain's ECM plays a crucial role in network formation, development, and regeneration of the c

Ageing, social participation, and everyday mobility : Facilitating age-friendly environments

Due to the increasing share of older people worldwide, the United Nations has directed an initiative towards a "decade of healthy ageing" to promote "age-friendly environments". This study aims to gain a deeper understanding of how to promote social participation and everyday mobility in later life. The ambition is to increase the knowledge about how to create more age-friendly environments and soDue to the increasing share of older people worldwide, the United Nations has directed an initiative towards a "decade of healthy ageing" to promote "age-friendly environments". This study aims to gain a deeper understanding of how to promote social participation and everyday mobility in later life. The ambition is to increase the knowledge about how to create more age-friendly environments and so

Innovation and Regional Economic Growth in China

Based on historical data and facts, China have long been a rich country to the global extent, China’s economic growth has been remarkable during the last few decades; during which, from what I see, the innovation boom after its opening to the world (ever since the end of 20th century) had played significant role during the process. In this paper, I will test my hypothesis in a quantitative way to

Testing and Modelling of Electrical Traction Machines : Performance Characterisation with Measurements from Transient Operation

This thesis presents methods to derive and model the performance characteristics of interior permanent magnet machines – a machine type which is commonly used for propulsion of electrical vehicles. The thesis divides the performance characteristics into three subcategories: The electromagnetic properties, the loss profile and the thermal behaviour of the machines. One separate characterisation met