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BACKGROUND: Prognostic factors for metastasis in soft tissue sarcoma govern decisions regarding adjuvant treatment. However, the significance of initial tumor-related prognostic factors over time is largely unknown.METHODS: The current study included 338 patients with malignant fibrous histiocytoma (MFH) of the extremities or the trunk wall whose tumors were reviewed by the Scandinavian Sarcoma Pa
This thesis includes four appended papers. The thesis describes the challenges and advantages of the use of FE-analysis in the design of a component forming process in the automotive industry. Today, shortened lead-times in the automotive industry have dramatically increased the need for more efficient development methods in each stage of the process development chain. In order to decrease the lon
Background: SCOR is a worldwide accepted and renowned process reference model that is developed and endorsed by the non-profit organization Supply Chain Council. It’s a cross-industry diagnostic tool for supply chain management. Consafe Logistics wanted to know if a performance measurement system for warehouse activities could be developed based on the SCOR model, and how it could be applied in th
Purpose: The purpose of the thesis is to critically review different pricing strategies with a special focus on Revenue Management and discuss the possibilities and challenges for hotels when optimising their profitability. Methodology: We have conducted three case studies on hotels located in the Öresund region. The studies were done with a qualitative research approach. The respondents are all w
In pursuit of energy efficiency and sustainable development, goals have been set by the EU and Sweden to improve the energy performance of buildings and reduce their environmental impact. Renovating the existing building stock is a path to achieving the energy and climate goals. This study investigates and analyses various retrofitting options for multifamily residential buildings in Skåne, Sweden
With an increase in temperature (T) and a change in precipitation (P) patterns due to climate change, global conditions for tree growth are changing and shifting. While some areas experience an increase in P, favoring tree growth, many regions are also predicted to show a decrease in P, leading to trends of desertification. This study examines the projected climate change in Nigeria, located in Su
Human-wildlife conflicts threaten the existence of many species worldwide. Large carnivores are often involved in such conflicts due to their diets and expansive home ranges. In Finland, wolf (Canis lupus) is one of such conflict-prone species. The wolf conflict is a multifaceted issue stemming for instance from fears, damages to domestic animals, competition for game and opposition of EU wildlife
Backgrund: Nederman har ett långsiktigt mål att förbättra enheten i Helsingborg. Ett steg i detta är att se om det finns några förbättringar att genomföra i lagerstyrningen i form av lager- och servicenivåer. Detta då de anställda upplever dagens verktyg som ganska trubbiga för det nuvarande produktsortimenetet och att detta kanske kan förbättras genom ytterliggare en dimension på det befintliga sBackground: Nederman has a long term goal of improving their supply unit in Helsingborg. One step of this is to investigate if there are any improvements to be made in the inventory control in terms of stock levels and service level. This since the employees at Nederman believes that the existing methods are too blunt as a tool for the product range and that their methods can be improved by adding
Thailand’s food retail sector was rapidly transformed during the past decade. This change was resulted in a substantial reduction in the number of traditional retailers as well as the sales of the existing ones while the number of modern retailers and their sales accelerated progressively. However, this can be seen as the must-happened transformation process, as it was also seen in other developed
The discovery of the Higgs boson h in 2012 further confirmed the remarkable accuracy of the Standard Model (SM). Despite this, some compelling excesses in multi-lepton final states were recorded in both major runs of the Large Hadron Collider (LHC). The excesses can be explained by the introduction of a model where a heavy boson X decays into a SM Higgs boson h and a singlet scalar S with Higgs-li
BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy
An integrated framework is introduced and applied to assess the health impact of airborne pollution with greater physiological relevance, moving beyond conventional exposure metrics. Measured particle number size distribution data was integrated with a regional respiratory tract deposition fractions to estimate total and alveolar deposited particle surface area concentrations. Land use regression
Climate change and its associated extreme events challenge the effectiveness of passive building design strategies. Hybrid passive-active systems emerge as a promising solution; however, their resilience in extreme climate conditions is less studied. This study addresses this gap by investigating the integration of solar chimneys (SC) with variable refrigerant flow (VRF) systems to improve thermal
Background: Patients with diabetes admitted to emergency care face a higher risk of complications, including prolonged hospital stays, admissions to the intensive care unit and mortality. Aim: To develop a machine learning (ML) model to predict 30-day mortality in patients with diabetes admitted to the emergency department (ED). Design and setting: A cohort study utilizing data from all nine ED’s
Many studies that use an automated sorption balance to determine a water vapor sorption isotherm for wood collect data until the moisture content change is less than or equal to 0.002% min−1 (20 µg g−1 min−1). This stop criterion has been claimed to give errors in equilibrium moisture content (EMC) predictions of less than 0.001 g g−1 but over the past 10 years, studies have shown that the actual
BACKGROUND: The standardized test used for evaluating the effect of warfarin is the prothrombin time (PT) which is measured and expressed in international normalized ratio (INR). Regular control of treatment intensity is required since inappropriate dosage increases the risk for complications. Portable point-of-care analytical instruments for measurement of capillary whole blood PT have been avail
Background and purpose Tibial osteotomy by the hemicallotasis technique (HCO) requires strong pin fixation. We compared pin fixation in HCO using a new self-drilling XCaliber pin (Orthofix) with optimized thread and tip design, with the commonly used standard pin (Orthofix). Patients and methods 50 patients, mean age 51 (35-66) years, to be treated by HCO were randomized to standard pins or XCalib
The possible contribution of HLA-DRB3, -DRB4 and -DRB5 alleles to type 1 diabetes risk and to autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 against either of the three amino acid variants, R, W or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear. Next generation sequencing (NGS) was therefore used to determine all DRB alleles
Scand J Caring Sci; 2011 Individual placement and support - a model to get employed for people with mental illness - the first Swedish report of outcomes Lack of participation in the open labour market is highly prevalent for people with a mental illness across countries, and the proportion of people who get some kind of sickness benefit because of mental illness is steadily growing in Europe. Voc
Combined CDK4/6 inhibitor (CDK4/6i) and endocrine therapy significantly improves outcome for patients with estrogen receptor-positive (ER+) metastatic breast cancer, but drug resistance and thus disease progression inevitably occur. Herein, we aimed to identify genomic alterations associated with combined CDK4/6i and endocrine therapy resistance, and follow the levels of specific mutations in long
