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Fast determination of whole blood glucose without any pretreatment was achieved using a calorimetric FIA micro-biosensor. Glucose oxidase was covalently immobilized, together with catalase, onto controlled pore glass beads and packed into a micro-column. By reducing the sample volume down to 1 μ1, a measurement period of about 40 s and an enlarged linear range of 0.5-20 mM glucose were obtained. T
Objective Elite para athletes report a high incidence of sports injuries. Research suggests that athletes’ strategies to manage adversities may influence the sports injury risk, but knowledge about para athletes’ coping behaviours and their association with injuries is limited. The aim was to describe the distribution of coping behaviours in Swedish elite para athletes by sex, age, impairment, spo
Objectives In youth sports, musculoskeletal pain is often studied from the standpoint of sports injuries, but little is known about pain conditions in which athletes still participate. The aim was to study the frequency of pain and associations with maturity offset, health status and sports performance in 14-year-old sport school students. Methods Cross-sectional design. One hundred and seventy-ei
This thesis addresses challenges in increasing the robustness of cloud-deployed applications and services to unexpected events and dynamic workloads. Without precautions, hardware failures and unpredictable large traffic variations can quickly degrade the performance of an application due to mismatch between provisioned resources and capacity needs. Similarly, disasters, such as power outages and
The purpose with this project was to create future self-service points for Skånetrafiken. The ticket machines that are in use today are difficult to interact with and excluding to people who are sight impaired or uses a wheelchair. Since Skånetrafiken are going to implement new self-service solutions in 2019 they want suggestions on how it could be designed. We thought that this project was an exc
TV-on-Demand service has become one of the most popular Internet applications that continuously attracts higher user interests. With rapidly increasing user demand, the existing network conditions may not be able to ensure low start-up delay of video playback. Prefetching has been broadly investigated to cope with the start-up latency problem which is also known as user perceived latency. In this
Distributed e-Infrastructure is a key component of modern BIG Science. Service discovery in e-Science environments, such as Worldwide LHC Computing Grid (WLCG), is a crucial functionality that relies on service registry. In this paper we re-formulate the requirements for the service endpoint registry based on our more than 10 years experience with many systems designed or used within the WLCG e-In
Sponge phase nanoparticles are lipid-based particles with a porous structure, forming pores with sizes up to 13 nm in diameter. These particles have been proposed for drug delivery by loading cargo within the pores, similar to how ionisable nanoparticles are used today. The larger pores could allow for larger cargo to be delivered to cells. Sponge phase nanoparticles, 277 ± 29 nm in diameter, were
Supramolecular hydrogels have attracted increasing attention in drug delivery, tissue engineering, and injectable biomaterials because of their high water content, good biocompatibility, and dynamic network structures. Cyclodextrin-based supramolecular systems can form network structures through host–guest interactions. These systems usually require mild cross-linking conditions and allow flexible
Protein therapeutics need to be formulated into an amorphous solid state to be stabilized, and this is efficiently done by spray drying together with a sugar matrix excipient. The characteristics of the produced powder are strongly dependent on process parameters, and therefore, spray drying offers the possibility of advanced particle engineering. In this thesis, trypsin was spray dried as a model
The controlled delivery of micronutrients to soil and plants is essential to increase agricultural yields. However, this is today achieved using fossil fuel-derived plastic carriers, posing environmental risks and contributing to global carbon emissions. In this work, a novel and efficient way to prepare biodegradable zinc-impregnated cellulose acetate beads for use as controlled release fertilize
Due to rapid development of bacterial resistance against antibiotics, an emerging health crisis is underway, where ‘simple’ infections may no longer be treatable. Antimicrobial peptides (AMPs) constitute a class of substances attracting interest in this context. So far, research on AMPs has primarily focused on the identification of potent and selective peptides, as well as on the action mode of s
Nanoparticle-based targeted drug delivery holds promise for treatment of cancers. However, most approaches fail to be translated into clinical success due to ineffective tumor targeting in vivo. Here, the delivery potential of mesoporous silica nanoparticles (MSN) functionalized with targeting ligands for epidermal growth factor receptor and C─C chemokine receptor type 2 is explored in lung tumors
In this study, the use of cubosomes for topical delivery of the antimicrobial peptide (AMP) LL-37 was investigated. Topical delivery of AMPs is of great interest for treatment of skin infections caused by bacteria, such as Staphylococcus aureus. AMP containing cubosomes were produced by three different preparation protocols and compared: (i) pre-loading, where LL-37 was incorporated into a liquid
