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https://www.sol.lu.se/media/utbildning/dokument/kurser/SVEM34/20171/SVEM41_vt17_1.pdf - 2026-07-24

BACKGROUND. Recently, the gene for cysteine-rich secretory protein 3 (CRISP-3) was reported to be highly upregulated in prostate cancer (PCa) compared to benign prostatic tissue. The current aims were to investigate diagnostic use of tissue expression and immunodetection in serum of CRISP-3 for detection or monitoring of PCa. METHODS. Radical prostatectomy specimens and tissue microarrays from tra

BACKGROUND: The NOCTET (NOrdic Certican Trial in HEart and lung Transplantation) trial demonstrated that everolimus improves renal function in maintenance thoracic transplant (FIX) recipients. Nevertheless, introduction of everolimus is not recommended for patients with advanced renal failure. We evaluated NOCTET data to assess everolimus introduction amongst TTx recipients with advanced renal fai

Objectives This study sought to determine whether serum levels of testosterone and estradiol associate with lower extremity peripheral arterial disease (PAD) in a large population-based cohort of elderly men. Background Few studies have explored the relationship between serum sex steroids and lower extremity PAD in men. Methods The Swedish arm of the MrOS (Osteoporotic Fractures in Men) study (n =

Popular Abstract in Swedish I min avhandling har jag studerat marina sedimentkärnor från två kustområden i SE Sverige, dels från Gåsfjärden, strax söder om Västervik i Småland, och dels från kusten utanför Karlskrona i Blekinge. Med syftet att studera hur Östersjöns kustmiljö har förändrats sedan mitten av Holocen (~5000 år sedan). Resultaten visar att kustmiljön har påverkats av flera stressfaktoIn this thesis, I used two coastal sediment sequences from SE Sweden to study how Baltic Sea coastal environment has changed since the mid-Holocene. The results show the coastal environment has been influenced by multi-stressors, such as climate change, shoreline regression and anthropogenic activities. Using the sediment sequence from Karlskrona Bay, past coastal environment between 7300 and 350

Mice deficient for SPI-group ETS transcription factors PU.1 or SPI-B fail to generate lymphocytes or do not mount normal antibody mediated immune responses, respectively. PU.1 expression is restricted to B-, T-lymphocytes and macrophages, while SPI-B is expressed in B- and T-lymphocytes. SPI-C is an ETS transcription factor closely related to PU.1 and SPI-B, and expressed temporarily during B-cell

Popular Abstract in Swedish Sophia Elisabeth Brenner (1659-1730) var Sveriges första stora kvinnliga poet. Hon var verksam som författare och lärd kvinna under femtio år, och var dessutom en flitig brevskrivare. Avhandlingen baseras på en inventering av bevarade brev till och från Sophia Brenner skrivna på latin, svenska, franska och italienska. Hennes nylatinska korrespondens med danske Otto SpeSophia Elisabeth Brenner (1659-1730) was Sweden's first great female poet, writing and publishing her poems over a period of fifty years. She was also, however, a prolific letter writer. The dissertation is based on an inventory of all the preserved letters to and from her written in Latin, Swedish, French and Italian. Her Neo-Latin correspondence with the Dane Otto Sperling the Younger is presen

BACKGROUND: There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain. METHODS AND RESULTS: We conducted a case-cohort study involving 10 529 incide

BACKGROUND: Consumption of a Mediterranean diet, adequate levels of physical activity, and energy-restricted lifestyle interventions have been individually associated with improvements in HDL functions. Evidence of intensive interventions with calorie restriction and physical activity is, however, scarce. OBJECTIVES: To determine whether an intensive lifestyle intervention with an energy-restricte

BACKGROUND: Patients with small intestinal neuroendocrine tumours (siNETs) usually present with advanced disease. Primary tumour resection without curative intent is controversial in patients with metastatic siNETs. The aim of this meta-analysis was to investigate survival after primary tumour resection without curative intent compared with no resection in patients with metastatic siNETs. METHODS:

BACKGROUND: To evaluate resource utilization and direct economic costs of care for patients treated with negative-pressure wound therapy (NPWT), using the Vacuum-Assisted Closure (V.A.C.) system, compared to standard moist wound therapy (MWT). METHODS: A total of 162 diabetic patients with post-amputation wounds (up to the trans-metatarsal level) entered a 16-week, randomized clinical trial. Patie

Background The potential mutagenic effects of cancer therapies and the growing number of young male cancer survivors have given rise to concern about the health of their offspring. Methods We identified all singleton children born alive in Denmark between 1994 and 2004 and in Sweden between 1994 and 2005 (n = 1 777 765). Of the 8670 children with a paternal history of cancer, 8162 were conceived n

Foraging in landfills enhances the probability of acquiring antimicrobial resistance (AMR) in wildlife and increases exposure to pollutants like metal(loid)s, pharmaceuticals and caffeine. Exposure to metal(loid)s in the environment may cause selective pressure on bacteria, inducing metal resistance genes that drive antimicrobial resistance genes (ARGs) through co-resistance and cross-resistance m

Rationale: Recent randomized controlled trials did not show cardiovascular benefits of continuous positive airway pressure (CPAP) in adults with coronary artery disease (CAD) and obstructive sleep apnea (OSA) in intention-to-treat analyses. It has been argued that exclusion of patients with OSA with excessive daytime sleepiness (EDS), who may be most likely to benefit from CPAP treatment, may be a

Abstract in Danish Observationsmetoder og billeddannelsesteknikker ? vurderinger af den fysiske eksponering i repetitivt arbejde med focus på nakke, skuldre og arme Formålet var at udvikle, etablere og validere observationsmetoder til eksponeringsvurderinger i epidemiologiske undersøgelser af repetitivt arbejde. Et andet formål var at øge kvaliteten af input data til brug i biomekaniske skuldermoObservation methods and imaging techniques - assessments of physical exposure in repetitive work with focus on neck and upper extremities The aim of this thesis was to develop, establish and validate observation methods for exposure assessments in epidemiological studies of repetitive work. A second aim was to increase the quality of input data for biomechanical shoulder models, by reliability an