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Using Deterministic Lateral Displacement (DLD), we are able to separate bacteria by their size and their chain length. This separation enables the study of these properties as factors of virulence.

OBJECTIVE: To compare the effects of care based on comprehensive geriatric assessment (CGA) as a complement to usual care in an outpatient setting with those of usual care alone. The assessment was performed 36 months after study inclusion.DESIGN: Randomized, controlled, assessor-blinded, single-center trial.SETTING: A geriatric ambulatory unit in a municipality in the southeast of Sweden.PARTICIP

Background: A childhood cancer diagnosis and treatment-induced somatic late effects can affect the long-term mental health of survivors. We aimed to explore whether childhood cancer survivors are at higher risk of psychiatric disorders later in life than their siblings and the general population. Methods: In this register-based cohort study (part of the Socioeconomic Consequences in Adult Life aft

Background: Pesticides and metals may disrupt thyroid function, which is key to fetal brain development. Objectives: To evaluate if current-use pesticide exposures, lead and excess manganese alter free thyroxine (FT4), free triiodothyronine (FT3), and thyroid stimulating hormone (TSH) concentrations in pregnant women from the Infants' Environmental Health Study (ISA). Methods: At enrollment, we de

Downstream processing of ABE fermentation broth is challenging issue. In this work, results of the application of both hydrophobic and hydrophilic commercial membranes during the pervaporation of ABE aqueous mixtures were investigated and presented. Hydrophobic pervaporation experiments were performed using ABE-water mixtures containing 0-5 wt% of organics in feed, using commercial membranes: POMS

The individual wishes and priorities of patients with advanced disease are too often neglected, making a deck of cards with statements reflecting potential wishes and priorities a useful conversation tool. However, in the most ill patients, the card selection and sorting process may be too strenuous. The aims of this study were to explore the wishes and priorities of patients receiving palliative

Phase contrast micro-CT is a powerful technique allowing imaging of soft tissue at synchrotrons or using lab- oratory sources. The use of contrast agents is a useful approach when imaging vascular structures. However, common x-ray contrast agents typically rely on heavy metals to increase absorption, which may affect the phase contrast and cause artifacts in the reconstructed volumes. Thus, utiliz

This study reports an impact evaluation carried out for a large-scale research infrastructure, the Brazilian Sirius Synchrotron Light Source, one of two fourth-generation synchrotron light sources in the world. We focus on the economic impacts and spillovers resulting from highly qualified procurements presented to different types of suppliers who participated in the design and construction proces

Developing and validating sensitive visual read algorithms for assessing Alzheimer disease-related tau in tau PET imaging is imperative, considering the implementation of the methodology in clinical practice and trials. Our aim was to compare 2 visual read algorithms for tau PET images to semiquantitative measurements and plasma phospho-tau 217 (p-tau217) status. Methods: In total, 1,654 participa

The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell communities that are important in shaping disease developmen

OBJECTIVES: To evaluate if ileo-psoas muscle size and visceral adipose tissue (VAT) can predict long-term survival after endovascular aneurysm repair (EVAR). METHODS: Patients who underwent EVAR between 2004 and 2012 in a single centre were included. Total psoas muscle area (TPA), abdominal VAT area, subcutaneous adipose tissue (SAT), and total adipose tissue were measured on the preoperative CT.

Structural Health Monitoring (SHM) plays a vital role in maintaining the integrity of structures by providing continuous information about damage or anomalies. Vibration-based SHM, which focuses on the dynamic behavior of structures, offers insights into structural conditions through changes in dynamic properties. Among SHM approaches, damage localization is crucial for pinpointing the geometric l

In order to qualify a subscriber loops for xDSL transmission, basic parameters like transfer function, scattering parameter S11 and characteristic impedance should be known. The aim of this paper is to present a test methodology for measurements of these basic parameters. The characteristic impedance is measured by open/short method and it is compared with the terminated measurement method defined

Flood risk mitigation requires collaborative governance that involves many and diverse actors. The capacity of municipal administrations to anticipate and adapt plays a crucial role in addressing flood risk in the Nordic region. However, although flood risk often spans boundaries, each organisation's governance capacity depends largely on the formation of collaborative ties among involved politici

Structural maintenance of chromosome (SMC) complexes organize and regulate genomes via DNA loop extrusion. During this process, the complexes increase the loop size by reeling in DNA from one or both sides of the loop. The factors governing this symmetry remain unclear. Here, we combine single-molecule analysis and molecular dynamic simulations to investigate the symmetry of loop extrusion of vari

Bacterial toxins, called superantigens, are produced by Staphylococcus aureus and are known to activate γδ T cells. γδ T cells contribute to long-lasting immunity against bacterial skin infections caused by S. aureus. γδ T cells are a distinct subgroup of T cells containing the T cell receptor (TCR) γ and δ chains. The γδ TCR harbouring the variable chains TRGV9/TRDV2 is the most common TCR in hum

BACKGROUND: As trials of 5 years of tamoxifen in early breast cancer mature, the relevance of hormone receptor measurements (and other patient characteristics) to long-term outcome can be assessed increasingly reliably. We report updated meta-analyses of the trials of 5 years of adjuvant tamoxifen.METHODS: We undertook a collaborative meta-analysis of individual patient data from 20 trials (n=21,4