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Introduction: Mer and Tyro3 are receptor tyrosine kinases important for the phagocytosis of apoptotic cells. Together with Axl, they constitute the TAM receptor family. These receptors can be shed from the cell membrane and their soluble extracellular regions can be found in plasma. The objective of this study was to elucidate whether the plasma levels of soluble Mer (sMer) and Tyro3 (sTyro3) were
The current study presents the long-term results from a study designed to evaluate a restaging positron emission tomography (PET) directed policy whereby neck dissections were omitted in all node positive head and neck squamous cell carcinoma (N+HNSCC) patients with PET-negative lymph nodes after definitive radiotherapy (RT), with or without chemotherapy.
The Ncf1 gene, encoding the P47PHOX protein that regulates production of reactive oxygen species (ROS) by the phagocyte NADPH oxidase complex, is associated with autoimmunity and arthritis severity in rats. We have now identified that the single nucleotide polymorphism (SNP) resulting in an M153T amino acid substitution mediates arthritis resistance and thus explains the molecular polymorphism und
Methodological differences in assessing dietary acrylamide (AA) often hamper comparisons of intake across populations. Our aim was to describe the mean dietary AA intake in 27 centers of 10 European countries according to selected lifestyle characteristics and its contributing food sources in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. In this cross-sectional ana
Manganese (Mn) enrichments in sediments of the deep basins of the Baltic Sea are believed to consist of Ca-Mn-carbonates that form from Mn oxides following periodic inflows of oxygen-rich North Sea waters. However, a range of Mn-bearing mineral phases, that besides Mn-carbonates (e. g. Ca-rhodochrosite), can include Mn-sulfides are known to be present in marine sediments, with formation mechanisms
The adaptor protein Grb10 plays important roles in mitogenic signaling. However, its roles in acute myeloid leukemia (AML) are predominantly unknown. Here we describe the role of Grb10 in FLT3-ITD-mediated AML. We observed that Grb10 physically associates with FLT3 in response to FLT3-ligand (FL) stimulation through FLT3 phospho-tyrosine 572 and 793 residues and constitutively associates with onco
The tick-borne bacterium 'Candidatus Neoehrlichia mikurensis' has recently been recognized as a human pathogen. Together with Borrelia afzelii, it is one of the most common pathogens found in the tick Ixodes ricinus. Here, we compared the epidemiology of 'Candidatus N. mikurensis' and B. afzelii by longitudinal sampling from May to September in one of their most abundant vertebrate hosts, the bank
AIMS: Induction of iNOS in pancreatic islets leads to exaggerated NO production associated with dysfunctional β-cells. We examined insulin secretion, iNOS expression and its relation to the cAMP system in islets from human type 2 diabetes. METHODS: Insulin, glucagon and cAMP were analyzed by RIA; iNOS or PDE expression by qPCR, Western blot and confocal microscopy; cell viability by MTS. RESU
The dynamics of particle formation were investigated for a diffusion-like ethylene flame containing a cooling metal plate on which particles condensed. Small-angle and wide-angle X-ray scattering techniques were combined to follow size- and structural changes of the soot particles using a new detector. The high dynamic range allowed continuous monitoring from the gas to the condensed phase of the
In the present study a fragmentary foot structure, associated with word stress, is assumed to be available in Spanish. In addition catalexis is introduced in the metrical analysis of Spanish stress. Acoustic evidence for catalexis is presented. The material consists of Spanish syllabic verse. Phrase-final stressed syllables assumed to be followed by catalexis were found to have 1.6 times longer du
Sammanfattning In the discussion on the relations between human rights and intellectual property a myriad of human rights are brought up, both directly and remotely connected to IP, but the right to cultural participation, which seems so relevant is, however, mentioned very rarely and even then - only superficially. The present paper is aimed at giving this neglected right a proper attention with
Health plays a vital role in every human’s life; and the centre for the maintaining and retaining our health lies in the health care. Thanks to innovations in health care technology and innovations of new drugs the health care is constantly improving, which contributes to improved survival probability and improved quality of life. However, this development in health care comes at a high price, sin
Biodiversity offsets have been proposed as part of the EU 2020 Biodiversity Strategy in order to achieve 'no-net-loss' of biodiversity. However, there is a growing number of criticisms towards the use of offsets, particularly from a political ecology approach. Drawing from analysis of key EU documents and working reports, this thesis examines whether the proposed use of biodiversity offset
This paper investigates the barriers that immigrant woman entrepreneurs (IWEs) face in starting their firms, and the strategies they use to overcome them. The study interviewed seven IWEs in Skåne, Sweden to gain a deeper understanding of their experiences. The study uses a theoretical framework that focuses on gender, family, culture, social and human capital and the institutional barriers as the
Recently, a widespread attention has been given to the protection of traditional cultural expressions and traditional knowledge. Their legal protection is even more urgent in the current global society. The focus in this thesis has been given to the copyright protection of traditional cultural expressions (TCEs). The purpose of this thesis is to assess the protection of TCEs under the copyright la
BACKGROUND AND PURPOSE A global company aiming at a high market position in the future, which Axis Communications AB is, is forced to address the emerging markets. Axis has previously focused on Brazil, Russia, and China and now it is time to address the fourth BRIC country; India, since it is considered to have one of the world's greatest market potential. Axis works according to their partne
The ongoing refugee crisis has divided the European Union. While some states shelter hundreds of thousands of refugees, others only grant asylum to a handful. This phenomenon is creating a demographic rift inside the union and is also causing internal quarrels over joint responsibility, which possibly could undermine the existence of the organization. In this thesis we search for the potential cau
