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Epicardial adipose tissue has a paracrine effect, enhancing coronary artery atherosclerotic plaque development. This study evaluated epicardial fat volume (EFV), adipokines, coronary atherosclerosis, and adverse cardiovascular events in a cohort of asymptomatic patients with type 2 diabetes mellitus (T2DM). Epicardial fat volume was calculated using data from computed tomography coronary angiogram
Background: Although survivors of childhood cancer are at risk of chronic pain, the impact of pain on daily functioning is not well understood. Methods: A total of 2836 survivors (mean age, 32.2 years [SD, 8.5 years]; mean time since diagnosis, 23.7 years [SD, 8.2 years]) and 343 noncancer community controls (mean age, 35.5 years [SD, 10.2 years]) underwent comprehensive medical, neurocognitive, a
The current research studied effects of different gender expressions (non-normative or normative)in two phases of recruitment: applicant attraction and applicant evaluation. Experiment 1 (N = 404) investigated how Equal Employment Opportunity (EEO) statements in an organisation description that emphasized gender as binary (women and men), gender as diverse (multi-gender), or gender as irrelevant (
Objective: The objective of this study was to investigate lower extremity function in early rheumatoid arthritis (RA) and assess its relation to other disease parameters. Methods: An inception cohort (recruited in 1995–2005) of patients with early RA was followed according to a structured protocol. Lower extremity function was investigated at inclusion and after 1, 2, and 5 years using the Index o
Background: Therapy directed at the central nervous system (CNS) is an essential part of the treatment for childhood acute lymphoblastic leukemia (ALL). The current evaluation of CNS involvement based on cytomorphological examination of the cerebrospinal fluid (CSF) alone is not as sensitive with low cell counts as flow cytometric immunophenotyping (FCI) of the CSF. However, the importance of low
Alpha1-microglobulin (alpha1m) is an electrophoretically heterogeneous plasma protein. It belongs to the lipocalin superfamily, a group of proteins with a three-dimensional (3D) structure that forms an internal hydrophobic ligand-binding pocket. Alpha1m carries a covalently linked unidentified chromophore that gives the protein a characteristic brown color and extremely heterogeneous optical prope
Global dementia rates will more than triple by 2050, thus challengingsociety. Due to ageing in place policies, informal caregiving is increasing asmore people with dementia continue living at home despite significant careneeds. While most caregivers are willing to act as such, they are notalways adequately supported, thus reporting a high burden, worse mentaland physical health. Innovative Assisti
AIMS: Using functional magnetic resonance imaging (fMRI) we investigated the cortical and subcortical representations during bladder filling and the effect of simultaneous stimulation of the dorsal clitoral nerve on these cortical and subcortical structures.METHODS: After approval of the local ethics committee, 8 healthy females were included. Prior to scanning, subjects were catheterized and the
This presentation addresses questions concerning the relationship between 1st, 2nd and 3rd cycles in higher music education (HME), and the transformative possibility of artistic research in conservatoire contexts. In the conservatoire tradition, knowledge and experience of music as both a craft and an art is held, transmitted and developed. Previous research shows that young students of classical
Kulturarvsfinansiering internationellt. Komparativ studie.
Nucleophilic properties of amino acid amides were studied systematically in acyl-transfer reactions catalyzed by α-chymotrypsin and subtilisin from Bacillus subtilis strain 72 (subtilisin 72) using Mal-L-Ala-L-Ala-L-PheOMe and Bz-L-TyrOme as the acyl group donors. In α-chymotrypsin-catalyzed reactions in water the reactivity of the amino acid amides increases with hydrophobicity of the nucleophile
Selective removal of the basal forebrain cholinergic neurons by the immunotoxin 192 immunoglobulin G-saporin has offered a new powerful tool for the study of the relationships between cholinergic dysfunction and cognitive impairments. In the present study the morphological and functional consequences of selective lesions of the basal forebrain cholinergic system during early postnatal development
Motor aspects of Parkinson's disease, such as fluctuations and dyskinesia, can be reliably evaluated using a variety of "wearable" technologies, but practical guidance on objective measurement (OM) and the optimum use of these devices is lacking. Therefore, as a first step, a panel of movement disorder specialists met to provide guidance on how OM could be assessed and incorporated into clinical g
We have imaged the emissions from excitons and free charges in a methylammonium lead bromide perovskite (MAPbBr3) crystal. In a direct band gap semiconductor, dynamics of excited electrons and holes in hybrid lead-halide perovskites is rather complex because of the formation of excitons and the presence of traps and structural inhomogeneities. A recent report by Nah et al. (Nah, S.; Spokoyny, B.;
Background: The bladder exstrophy-epispadias complex (BEEC) is a congenital malformation of the bladder and urethra. The underlying causes of this malformation are still largely unknown; however, aside from environment, genetics is thought to play an essential role. The recurrent 22q11.2 microduplication is the most persistently detected genetic aberration found in BEEC cases. Methods: We performe
This paper introduces a new experimental method to monitor the evolving intra-particle, nanometre-scale response during hydro-mechanical tests on undisturbed wet clay samples using small angle X-ray scattering (SAXS). The method uses a newly developed miniature plane-strain one-dimensional compression cell that facilitates simultaneous full-field surface displacement measurements using digital ima
