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Background The oestrogen receptor beta (ERβ) is the predominant oestrogen receptor in the normal colon mucosa and has been reported to exert anti-proliferative and pro-apoptotic effects. However, the role of ERβ in colorectal cancer (CRC) progression remains unclear. Aim To investigate the role of ERβ and its association with hormone status and lifestyle indicators in a female cohort of patients w
The purpose is to analyse and explain factors determining whether conventional trade with stores or e-commerce with home delivery is more energy-efficient. The findings from previous studies are compared in order to identify more general patterns of energy consumption, describe which energy consumption factors (product waste and product returns, buildings, packaging, passenger transport and freigh
Cu/Zn superoxide dismutase (SOD1) forms intracellular aggregates that are pathological indicators of amyotrophic lateral sclerosis. A large body of research indicates that the entry point to aggregate formation is a monomeric, metal-ion free (apo), and disulfide-reduced species. Fibril formation by SOD1 in vitro has typically been reported only for harsh solvent conditions or mechanical agitation.
We have compared the anatomic and functional regeneration of a transected sciatic nerve following regrowth from its proximal stump through either preformed empty mesothelial chambers or autologous nerve grafts bridging a 10 mm gap. Within the mesothelial chambers an organized multifascicular nerve trunk forms between the proximal and distal stumps. After 3 months, distal segment cross sections fro
BACKGROUND: Potassium supplementation reduces the risk of cardiovascular mortality and stroke in population studies; however, the prognostic impact of mild hypokalemia in the general population has not been thoroughly investigated. We aimed to investigate associations between mild hypokalemia and endpoints in the general population.METHODS: participants (48-76 year old) from the general population
This study investigates summer high temperature extremes (HTEs) in southeast China and their linkage with the El Nino-Southem Oscillation (ENSO) and atmospheric circulations in the East Asian summer monsoon (EASM). An interdecadal change in HTEs associated with the abrupt shift of the ENSO monsoon climate in the late 1980s is demonstrated. Before this interdecadal shift, the interannual variabilit
BACKGROUND: KRAS mutations represent key alterations in colorectal cancer development and lead to constitutive EGFR signaling. Since EGFR inhibition represents a therapeutic strategy in advanced colorectal cancer, KRAS mutation analysis has quickly been introduced as a treatment-predictive test.METHODS: We used a real-time PCR based method to determine KRAS mutations in 136 colorectal cancers with
Our aim was to study whether the in situ natural abundance N-15 (delta(15)N)-values and N concentration of understory plants were correlated with the form and amount of mineral N available in the soil. Also to determine whether such differences were related to earlier demonstrations of differences in biomass increase in the same species exposed to nutrient solutions with both NO3- and NH4+ or to N
Object: This study investigates the outcome after traumatic brain injury (TBI) in mice lacking the essential DNA repair gene xeroderma pigmentosum group A (XPA). As damage to DNA has been implicated in neuronal cell death in various models, the authors sought to elucidate whether the absence of an essential DNA repair factor would affect the outcome of TBI in an experimental setting. Methods: Th
The aim of this project has been to study timber house manufacturers and provide guidance to those who aim to increase efficiency through the adaption of product modeling and eventually configuration. The findings in this report are based on a series of case studies within the abovementioned industry, which serves as a basis for the analysis and recommendations given. The Swedish timber house man
Abstract is not available
The press-fit condylar (PFC) cruciate-retaining total knee prosthesis is well documented in the literature. In 1997, a modification of the femoral component was introduced, and the prosthesis was renamed PFC-Sigma. The alteration may influence the migratory and rotational pattern of the tibial component and thus long-time survival rate. In this radiostereometric analysis, we found that the micromo
The aim of the present study was to investigate the distribution of suicide attempts across the depressive episodes in suicides and controls with a severe depression. A blind record evaluation was performed of 100 suicide victims and matched controls admitted to the Department of Psychiatry between 1956 and 1969 and monitored to 2006. There was a similar number of episodes in suicides and controls
The objective was to investigate prevalence, estimate risk factors, and antenatal suspicion of abnormally invasive placenta (AIP) associated with laparotomy in women in the Nordic countries.
The Eurasian Group on Combating Money Laundering and Financing of Terrorism (EAG), as a Financial Action Task Force (FATF)–style regional body (FSRB), synchronises national legislations across Central Asia to combat money laundering and financing terrorism through FATF mechanisms, aiming to eliminate external stresses on large economies. However, the hardening of FATF’s soft law approach through e
Given incumbent-led autocratization in Tunisia, the article investigates support to democracy among youth in historically marginalized regions and the likelihood they will prefer the authoritarian alternative. Putting forth a framework for micro-level assessment of the cognitive and interpretive dynamics generating loss of popular support to democratic transition, the research problematizes the re
