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1. 1. Endogenous phospholipase A2 (PLA2) inhibitors in human plasma and in plasma from the hedgehog (Erinaceus europaeus) were demonstrated. 2. 2. The PLA2 activity increased 45-fold in human plasma when a PLA2 binding factor was removed. Furthermore, two peaks of PLA2 inhibitory activity were found after DEAE-chromatography. 3. 3. High levels of PLA2 inhibitory activity was found in plasma from t
Wang Q, Pantzar N. Jeppsson B, Weström BR, Karlsson BW. Increased intestinal marker absorption due to regional permeability changes and decreased intestinal transit during sepsis in the rat. Scand J Gastroenterol 1994;29:1001-1008. Background: The intestinal barrier properties are impaired during inflammation and sepsis, but the mechanisms behind this are unknown and were therefore investigated du
Polycrystalline cubic boron nitride (pcBN) is a very promising tool material for turning martensitic stainless steels at high cutting speeds (vc > 200 m/min). The competitive advantage of pcBN over cemented carbide increases as the cutting speed is increased. Changing the speed might lead to a shift in the wear balance and hence the knowledge about tool wear below vc = 200 m/min might not be appli
This paper draws on critical discourse analysis to examine how health and physical education (HPE) curricula from Sweden, Norway, South Africa, Australia, and New Zealand may influence possibilities for the enactment of social justice in schools. The findings highlight the presence of social justice intentions across the five curricula as related to embodied movement experiences, social cohesion,
This study examined driver failure and traffic conflict using a driving simulator during lane-change scenarios on a 2+1 road, focusing on differences between day and night conditions. Data on driver failure status and driving behavior were captured through a survey. The study also evaluated driver performance and electrodermal activity. The findings revealed that nighttime lane changes had a short
Introduction Anorectal malformations (ARMs) are complex congenital anomalies of the anorectal region, oftentimes also affecting the genitourinary system. Although successful surgical correction can often be achieved in the neonatal period, many children will experience functional problems in the long term. The European Reference Network for rare and complex urogenital conditions (eUROGEN) assemble
Drug company funding can create conflicts of interest that compromise the integrity of patient organizations, a problem studied primarily in Western Europe and North America. To address this research gap, we conducted a case study in Poland, a Central European country. Between 2012 and 2020, 33 companies reported payments worth €13 729 644 to 273 patient organizations in Poland. The funding was hi
Adult neurogenesis continues throughout life but declines dramatically with age and in neurodegenerative disorders such as Alzheimer's disease. In parallel, microglia become activated resulting in chronic inflammation in the aged brain. A unique type of microglia, suggested to support neurogenesis, exists in the subventricular zone (SVZ), but little is known how they are affected by aging. We anal
Background: It is thought that patients with inborn errors of immunity (IEI) are more susceptible to severe coronavirus disease 2019 (COVID-19) than the general population, but a quantification of this potential risk is largely missing. Objective: We assessed the impact of COVID-19 on patients with IEI. Methods: A nationwide cohort study was performed to estimate the relative risk (RR) for hospita
BACKGROUND: Physical activity (PA) after stroke has significant health benefits if it is conducted regularly, with sufficient intensity and duration. Because of the health benefits, it is important to identify those below the World Health Organization (WHO) recommended level of PA. However, few studies have assessed the level of PA after stroke in relation to the WHO recommendations and which soci
Aims: Reirradiation is becoming more frequently used in paediatric tumours of the central nervous system (CNS). To fill the void of clinical guidelines, the Swedish Working Group of Paediatric Radiotherapy compiled consensus guidelines on reirradiation in 2019. The aim of this study was to evaluate the outcome of children reirradiated for CNS tumours since implementing the guidelines. Material and
In this study, laminar burning velocities (LBV) of ammonia in oxygen-enriched air (oxygen content ranging from 30 to 50 vol%) were investigated under various initial temperatures (298, 323, and 348 K) at a pressure of 1 atm, employing the heat flux method. Our measurements reveal substantial disparities with previously published data primarily obtained using the spherical flame method. The reliabi
We investigate the behaviors used by households to economize on their spending on food using data from a budget survey of urban households in sweden in 1913-1914. Higher-income households bought higher quality varieties of both luxury and staple foods. But changing the composition of the diet was a much more important way to adjust spending on food than changing the quality of the foods bought. Hi
Artikeln bygger på en utvärdering som gjordes 2021-2022 när den brottspreventiva metoden SafeGrowth testades i området Drottninghög. Artikel utgår från ett polisperspektiv och visar på möjligheter med metoden, men också svårigheten att implementera en metod utvecklad i en specifik kontext, i andra miljöer.
Background: Therapies that could further prevent the development of heart failure (HF) and other cardiovascular and metabolic events in patients with recent myocardial infarction (MI) represent a large and unmet medical need. Methods: DAPA-MI is a multicenter, parallel-group, registry-based, randomized, double-blind, placebo-controlled phase 3 trial in patients without known diabetes or establishe
Scientific uncertainty is clearly a prominent hurdle in public health policy and the policy choices made to tackle this uncertainty are largely left to the Member States. Indeed, the Court of Justice of the EU has long since held that the health and the life of humans rank first among the interests that Member States can legitimately pursue - even if they restrict the market freedoms in doing so -
Aims Our objective was to assess changes in the birth prevalence of CHD over a half-century in a high-resource, nationwide setting, as well as changes in the prevalence of cardiac interventions in this population. Methods The Swedish National Patient and Cause of Death registers were linked to estimate the annual rates of CHD and cardiac and results interventions among live-born infants from 1970
This article presents experimental data sets about the evacuation movement and behaviour of preschool children observed during 15 evacuation drills in 10 nursery schools in the Czech Republic involving 970 children (3–7 years of age) and 87 staff members. The movement characteristics and behaviour of the children were studied in 100 measurement areas defined on evacuation routes in corridors, on s
