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Background: Current systemic therapies for metastatic pancreatic ductal adenocarcinoma are associated with poor outcomes with a 5-year overall survival rate under 5%. We aimed to assess the safety and antitumour activity of mitazalimab, a human CD40 agonistic IgG1 antibody, with modified FOLFIRINOX (mFOLFIRINOX; fluorouracil, leucovorin, oxaliplatin, and irinotecan), in chemotherapy-naive patients
The wax apple (Syzygium samarangense) is traditionally employed as an antibacterial and immunostimulant drug in traditional medicine. This plant is rich in different flavonoids and tannins. In this study, we isolated two compounds from S. samarangense leaves: Myricitrin and 3,5-di-O-methyl gossypetin. Then, we investigated the mechanisms of action of the two compounds against oxidative stress (ind
Aims: Among patients with myocardial infarction (MI) with preserved left ventricular ejection fraction (LVEF), the REDUCE-AMI trial did not demonstrate a benefit of beta-blocker vs. no beta-blocker treatment on all-cause mortality and recurrent myocardial infarction. The aim of this pre-specified sub-study was to investigate effects of beta-blockers on self-reported symptoms of anxiety and depress
During recent years the increasing power of computers and communications has led to the use of more advanced analysis approaches within the mechanical engineering design process, or design process for short. Predictive Design Analysis (PDA), see [1], is an approach in which the final behavior of a product is predicted by combining information from different analysis techniques. This paper presents
The purpose of this paper was to assess how the EU chemical regulation, REACH, affected the reform of the U.S. Toxic Substances Control Act. It borrows from theories of policy diffusion and of the EU as a regulatory power, which were used to theorize two causal mechanisms potentially leading to convergence between the European and American chemical regulations, tested using a method of process-tra
Title: Frenemies in Business: A Case Study on the Phenomenon of Coopetition Research Question: What are drivers and challenges behind coopetition, as well as possible outcomes of the relationship? Keywords: Coopetition, Cooperation, Competition, Coopetitive Relationship, Competing Companies, Coopetitors, Coopetition Process, Drivers, Challenges, Possible Positive Outcomes, Possible Negative Out
Idag bor cirka en miljard människor i världen i informella bosättningar och saknar tillgång till avfalls- och sanitetstjänster samt stadsinfrastruktur. I Rio de Janeiro bor cirka 1,4 miljoner människor, en fjärdedel av stadsbefolkningen, i informella bosättningar, eller favelor som det heter i Brasilien. Bristerna i stadens avfallshanteringssystem manifesterar sig huvudsakligen genom ansamling av Today, about one billion people in the world live in informal settlements and lack access to basic services and city infrastructure. In Rio de Janeiro, approximately 1,4 million people, one fourth of the city population, live in informal settlements, in Brazil called favelas. The insufficiency of the city’s waste services mainly manifests itself through accumulation of waste in public spaces in th
Predicting future large claims, as well as the total cost, of a specific insurance is essential for insurance companies, for example when setting premium levels or purchasing reinsurance coverage. The purpose of this thesis is to investigate if extreme value theory can be applied to construction defect insurance claims. Data is provided by an insurance company offering construction insurance and
Globalization is an increasingly pervasive factor in the economy, and due to the increasingly international market and competition, it is becoming progressively difficult for firms in traditional, mature industries in high-wage countries to remain competitive. This thesis highlights the case of the Småland-Blekinge region that is performing paradoxically well, largely due to a manufacturing indust
Syfte: Syftet med den här uppsatsen är att problematisera mångfaldshanteringen genom att studera mångfald där den praktiseras, bland de anställda. Med hjälp av anställdas perspektiv vill vi undersöka hur ett företag i Sverige praktiskt jobbar med diversity management. För att detta ska bli möjligt är det samtidigt viktigt att förstå ledningens perspektiv, därför kommer vi att ta med även denna. Vi
Popular science: Find a suitable area for rainwater harvesting Rainwater harvesting is a technique to capture and store rainfall where it falls. The technique of water harvesting can be used for different purposes, e.g providing irrigation water, drinking water, increase groundwater recharge, and reduce flood risk. The application of rainwater harvesting is suitable in arid and semi-arid areas, w
Human Capital is deemed as an imperative factor for economic growth, however, it is argued the extent of this interrelation. Acemoglu, Gallego and Robinson (2014) claim that the institutional framework of a nation, in specificthose of private property are deemed as pivotal for a nation’s development. In this sense, in order to contectualise this argument, the current thesis focuses on the case of
Syftet med studien är att undersöka hur implementeringen av byggherredrivna detaljplaneprocesser har fungerat i de kommuner som undersökts. Studien visar på att det inte finns någon större skillnad när det gäller kostnad, tid eller kvalitet vid en jämförelse av en byggherredriven och en traditionellt driven detaljplan. Studien visar även på att en byggherredriven detaljplan är mer genomförbar än The purpose of the study is to investigate how the implementation of local plans produced by the developer have worked in the investigated municipalities. The study shows that there is no major difference in costs, time or quality in between a local plan produced by the developer or the municipality. The study shows that a local plan produced by the developer is easier to implement then a plan pr
Denna studie fokuserar på barnet som brottsoffer och behandlar barnets ställning i brottmålsprocessen. Barn som brottsoffer är att se som s.k. skyddslösa i och med att de utgör en särskilt utsatt grupp, detta med tanke på deras beroendeställning till vuxna. Denna utsatthet gör barnet i behov av ett särskilt skydd i rättssystemet. Det har därför i den straffrättsliga och straffprocessrättsliga lagsThis study concerns the child as a victim of crime and deals with the child's position in criminal proceedings. Children as victims of crime are seen as so-called defenceless since they constitute a particularly vulnerable group, this considering their dependence on adults. This vulnerability makes the child in need of special protection in the justice system. Therefore, in the criminal and cr
The purpose of this thesis is to shed light on the role of Track II and Track III diplomacy as a means to shape Sino-Japanese relations. It studies the Track II and Track III diplomacy and its interplay and interrelations with Track I diplomacy in Sino-Japanese relations since the end of the WWII. It analyzes the function of Track II and Track III (or non-governmental) diplomacy and their interrel
Uppsatsen ”’The promise of participation culture’: Publikens deltagande i crowdfundingskampanjer” är författad av Sergey Vasiliev under kursen i medie-och kommunikationsvetenskap, vid Institutionen för kommunikation och medier, Lunds universitet. Uppsatsen är en fallstudie av två framgångsrika med olikartade crowdfundingskampanjer, ”Veronica Mars Movie Project” och ”The Pirate Bay – Away From Key
The critics about poor performance of NGOs over the last two decades focuses on their inclination towards ‘big D’ development – project based intentional activity in health, education and water which has little intention to challenge existing power relation and social structures - and underlined the loss of transformatory edge of participation. Critics further urged NGOs to realign their orientati
