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Three-phosphoglycerate dehydrogenase (3- PGDH) deficiency is a rare recessive inborn error in the biosynthesis of the amino acid L-serine characterized clinically by congenital microcephaly, psychomotor retardation, and intractable seizures. The biochemical abnormalities associated with this disorder are low concentrations of L-serine, D-serine, and glycine in cerebrospinal fluid (CSF). Only two m
Purpose Distal radius fracture often compromises working ability, but clinical implications are less studied in men due to its lower incidence. This study therefore describes sick leave in men with distal radius fracture, specifically exploring the impact of patient- and fracture-related factors. Methods Professionally active men aged 20–65 with distal radius fracture were followed prospectively f
The Ordovician Period has emerged as a highly dynamic time in Earth history. Comprehensive work on chrono, chemo-and biostratigraphy has resulted in an overall wellconstrained systemic framework, but several local successions around the globe still await detailed analysis in many respects. Herein we perform a highresolution analysis of abiotic and biotic signals in the Lynna River section, a key l
Religious organizations are social systems operating in a complex and changing environment. By looking to an authority beyond themselves, religious organizations have comparatively little control over defining their own goals. In this juggling between sticking to the ultimate goal of an organization and adapting to complex changing environments, that is, in the juggling between tradition and renew
Economic theory predicts that differences in wages for workers with similar skills will decline as labour mobility increase. This prediction is reminiscent of the ‘law of one price’, the notion that markets, if unfettered, eliminates price differentials of similar commodities across space. But can we really apply the economic logic of the commodity market to the labour market, governed as it is by
Airborne particulate emissions originating from the wear of pads and rotors of disc brakes contribute up to 50% of the total road emissions in Europe. The wear process that takes place on a mesoscopic length scale in the contact interfaces between the pads and rotors can be explained by the creation and destruction of contact plateaus. Due to this complex contact situation, it is hard to predict h
Incommensurate order, in which two or more mismatched periodic patterns combine to make a long-range ordered yet aperiodic structure, is emerging as a general phenomenon impacting the crystal structures of compounds ranging from alloys and nominally simple salts to organic molecules and proteins. The origins of incommensurability in these systems are often unclear, but it is commonly associated wi
In order to gain insights into the biogeographic processes underlying biotic diversification in the Atlantic Forest (AF), we used a multi-locus approach to examine the evolutionary history of the White-shouldered Fire-eye (Pyriglena leucoptera) and the Fringe-backed Fire-eye (Pyriglena atra), two parapatric sister species endemic to the AF. We sequenced one mitochondrial, three Z chromosome-linked
Among the disputes concerning political, historical, and cultural priority that beleaguered Swedish-Danish relations during the sixteenth and seventeenth centuries, the quarrel over the provenance of the heraldic emblem of the Three Crowns played a central role. In Sweden the dispute led directly to the formation of an expansive, state-managed heritage industry that remains largely intact today. T
Food security is one of the world’s greatest challenges. The current food system shows an entanglement across the globe which means that local farmers reliant on subsistence agriculture no longer operate in isolation of larger-scale processes within the global economy or the changing biophysical system of the planet. The persistently high number of undernourished people, volatile food prices, incr
Based on a unique set of three drill cores, we characterize the quantity, origin and degradation state of organic matter through the subsea permafrost with higher resolution across the current thaw front, to improve our understanding of its vulnerability to decomposition upon thaw.
The main component of the sex pheromone secretion of female Diprion pini L. (Hymenoptera: Diprionidae) from insects collected both in Finland and in France has been identified as a threo-3,7-dimethyl-2-tridecanol (8 ng per female) stereoisomer by GC-MS and synthesis. The secretion also contains lower and higher homologues in small amounts (1-4% of the main component). Combined gas chromatographic-
Abstract. 1. The bole of a Norway spruce, Picea abies(L.) Karst., was cut in 25 cm sections and infested in the laboratory with 2 or 8 females/dm2 of Ips typographus (L.) and an equal number of males. 2. One log of each beetle density was dissected every second day, beginning 2 days after female introduction. 3. The oviposition rate was highest at the beginning of the breeding period for both den
Broad-sense heritability of fluctuating asymmetry and developmental instability in the winter moth were analysed in a full-sib breeding experiment. Effects of both genetic background and common environment on both tibia FA (measured for the three pairs of legs) and body size were studied. As body size has previously been shown to be a reliable indicator of larval feeding success and expected fitne
