Filetype
Mitochondria produce the majority of the cell’s energy. Any dysfunction in, or interference with mitochondrial function can have severe consequences. And yet, it was only within the last decades that screening for potential mitochondrial toxicity was included as routine toxicity assay during early drug development. Despite improved recognition of drug-related side effects on mitochondrial function
The latest discovery of microfossils from the lower Cambrian (Fortunian Stage) Zhangjiagou Lagerstätte in South China are presented. This lagerstätte is rich in exceptionally preserved microfossils, including embryos of Olivooides multisulcatus, Olivooides mirabilis, and Pseudooides prima; hatched stages of O. multisulcatus, O. mirabilis, Hexaconularia sichuanensis, and Quadrapyrgites quadratacris
Adaptation is regarded as a panacea among policy circles. This paper offers a somewhat different perspective, using life narratives to investigate the conflictual nature of adaptation in and around vulnerable communities in Nepal and Maldives. Our analysis results in a framework with three dimensions: (1) qualitative differences in type of conflict; (2) the relative positions of the conflicting ac
The recent increase in the migratory flows of Syrian asylum-seekers has drawn attention to the causes and, more fundamentally, to the consequences of such mobility patterns in both the European Union and in Turkey. In this paper we explore the healthcare system in Turkey and, particularly, Syrians' access to healthcare services. Bringing together the literature on healthcare and on mobility from c
The overall purpose of this thesis is to improve our understanding of how disaster risk management (DRM) systems function. Specifically, it aims to increase our knowledge about effective communication in a multi-stakeholder, multi-level DRM system, with a particular focus on the exchange of risk-related information for risk assessment. The Swedish DRM system is taken as a study case to examine how
This paper provides an analysis of the role of technical advances and upscaling practices in the steel sector and the differences in these practices between planned and market-based economies. It focuses on the Czechoslovak steel sector, comparing it to other planned economies as well as Western economies. The primary method of analysis employed is the logistic-fit curve of technology diffusion, c
This paper makes a contribution to the study of emotions in organizations by offering a systematic juxtaposition and cross-fertilization of psychoanalytic and social constructionist approaches. These two traditions have found it hard to communicate in the past when addressing organizational emotions. Points of similarity and tension between them are discussed in connection with two critical case s
Photo-generated charge carrier dynamics in Ruddlesden-Popper 2D perovskites with linear (n-BA) and branched (iso-BA) butylamine as spacing cations have been studied by using transient absorption and time-resolved photoluminescence spectroscopies. Both n-BA and iso-BA perovskites consist of mixed-phase 2D quantum wells with various layer thicknesses, where the photo-generated charges undergo inter-
The end-Permian mass extinction was the most severe biotic crisis in Earth's history. In its direct aftermathmicrobial communities colonized some of the space left vacant after the severe decline of skeletal metazoans.The Permian-Triassic boundary microbialites were peculiarly abundant on low-latitude shallow-marine carbonateshelves of central Tethyan continents. Armenia features particularly well
This paper investigates the petrogenesis of the Seqi Ultramafic Complex, which covers a total area of approximately 0.5 km2. The ultramafic rocks are hosted by tonalitic orthogneiss of the ca. 3000 Ma Akia terrane with crosscutting granitoid sheets providing an absolute minimum age of 2978 ± 8 Ma for the Seqi Ultramafic Complex. The Seqi rocks represent a broad range of olivine-dominated plutonic
Aim: Metformin is the first-line treatment for Type 2 diabetes. However, not all people benefit from this drug. Our aim was to investigate the effects of metformin on the plasma metabolome and whether the pretreatment metabolite profile can predict HbA1c outcome. Methods: Post hoc analysis of the Copenhagen Insulin and Metformin Therapy (CIMT) trial, a multicentre study from May 2008 to December 2
Global carbon balances are increasingly affected by large fluctuations in productivity occurring throughout semiarid regions. Recent analyses found a large C uptake anomaly in 2011 in arid and semiarid regions of the southern hemisphere. Consequently, we compared C and water fluxes of two distinct woody ecosystems (a Mulga (Acacia) woodland and a Corymbia savanna) between August 2012 and August 20
It is well known that material properties are size dependent at small enough geometrical scales. With the advance of technology and computational power, we are now able to bridge the atomistic or even electronic scale phenomena with macroscopic properties of materials. A strategy to capture the electronic structure effect is to perform first principles calculations. Here we present results of firs
Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at rec
Persons who frequently visit psychiatric emergency rooms (PERs) account for a disproportionately high number of total visits to PERs. They have needs just as any other human beings do. Yet in addition, they also have specific daily function needs, service needs, and needs for professional healthcare.The overall aim of this thesis was to investigate who persons frequently visiting PERs in Sweden ar
For decades, the media have frequently been instrumental in framing rape cases by linking the deed with the place. This study demonstrates that law courts are not innocent of such social framing; on the contrary, they are significant agents. We argue that courts, by shaping the plot in rape cases, participate in an ongoing cultural production of meaning, although in a more subtle and ambivalent wa
