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Mitochondria play an essential role to supply the cell with metabolic energy in the form of adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). As a consequence, they are also the primary source of cellular reactive oxygen species (ROS) which can cause oxidative damage of individual respiratory chain complexes. Indeed, affected OXPHOS subunits result in decreases in ATP produc

This chapter deals with the Swedish tv-series Somewhere in Sweden, broadcast on public television (SVT) in 1973 and 1974 and seen by more than 60 percent of the Swedish population. It has since its initial screening, been broadcast on several occasions, always reaching large audiences. Here, an analysis is presented in which it is emphasised that the series expressed a common view of the World Wa

Previous studies have suggested that thyroid function is associated with breast cancer risk, which could have an important clinical impact, as one in eight women will develop a thyroid disorder during her lifetime. However, the underlying pathomechanism behind the association is still unknown. We used the Malmö Diet and Cancer Study (a population-based prospective study consisting of 17,035 women)

The Franco-Chinese migrant writer François Cheng (Grand Prix de la francophonie de l’Académie française 2001) is the first French Academician of Asian origin. His French-language novel Le Dit de Tianyi (Prix Femina 1998, rather differently translated into English as The River Below) recounts the protagonist’s life trajectory across the turbulent twentieth century, from wartime China to France and

Aim: To report basic epidemiological data concerning surgically treated childhood cataract in Sweden and Denmark. Methods: Data were derived from the Paediatric Cataract Register (PECARE), a binational, web-based surgical register representing Sweden and Denmark. All children operated before 8 years of age between 1 January 2007 and 31 December 2013 were included. Age-specific prevalence per 100 0

Why do people engage in collective actions, such as demonstrations? We suggest that intentions to engage in protest activities come from the perception that the action is an efficient way to affect policy but is also dependent upon the level of others’ engagement. Specifically, lower support should spur intentions to engage if the individual believes that the collective act is an efficient means t

A combined measurement and Monte-Carlo simulation study was carried out in order to characterize the particle self-shielding effect of B4C grains in neutron shielding concrete. Several batches of a specialized neutron shielding concrete, with varying B4C grain sizes, were exposed to a 2 Å neutron beam at the R2D2 test beamline at the Institute for Energy Technology located in Kjeller, Norway. The

In this essay in honour of Christina Moëll, we focus on one particular recent case: the Philip Morris case delivered in May 2016 where the European Court of Justice (ECJ) rules on the validity of the Tobacco Product Directive case.1 It is a key case on the application of the principle of proportionality but not only since it connects this principle with other constitutional principles putting limi

Background: Transient ischemic attacks (TIA) indicate an increased risk of stroke, one of the leading causes of death and disability worldwide. In order to prevent stroke, our knowledge of diagnosis, demographics, risk factors, investigations, and treatment of patients with TIA needs to be improved.Aims: The aims of this thesis were to validate data and diagnoses in the Riksstroke TIA module (Riks

OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a major health problem with high societal costs. The Global Initiative for Chronic Lung Disease (GOLD) has identified a need for health economics data for COPD. For chronic diseases, such as COPD, where the natural history of disease is lifetime, a modeling approach for economic evaluation may be more realistic than prospective, piggy-back

Mitochondria produce the majority of the cell’s energy. Any dysfunction in, or interference with mitochondrial function can have severe consequences. And yet, it was only within the last decades that screening for potential mitochondrial toxicity was included as routine toxicity assay during early drug development. Despite improved recognition of drug-related side effects on mitochondrial function

The latest discovery of microfossils from the lower Cambrian (Fortunian Stage) Zhangjiagou Lagerstätte in South China are presented. This lagerstätte is rich in exceptionally preserved microfossils, including embryos of Olivooides multisulcatus, Olivooides mirabilis, and Pseudooides prima; hatched stages of O. multisulcatus, O. mirabilis, Hexaconularia sichuanensis, and Quadrapyrgites quadratacris

Adaptation is regarded as a panacea among policy circles. This paper offers a somewhat different perspective, using life narratives to investigate the conflictual nature of adaptation in and around vulnerable communities in Nepal and Maldives. Our analysis results in a framework with three dimensions: (1) qualitative differences in type of conflict; (2) the relative positions of the conflicting ac

The recent increase in the migratory flows of Syrian asylum-seekers has drawn attention to the causes and, more fundamentally, to the consequences of such mobility patterns in both the European Union and in Turkey. In this paper we explore the healthcare system in Turkey and, particularly, Syrians' access to healthcare services. Bringing together the literature on healthcare and on mobility from c

The overall purpose of this thesis is to improve our understanding of how disaster risk management (DRM) systems function. Specifically, it aims to increase our knowledge about effective communication in a multi-stakeholder, multi-level DRM system, with a particular focus on the exchange of risk-related information for risk assessment. The Swedish DRM system is taken as a study case to examine how

This paper provides an analysis of the role of technical advances and upscaling practices in the steel sector and the differences in these practices between planned and market-based economies. It focuses on the Czechoslovak steel sector, comparing it to other planned economies as well as Western economies. The primary method of analysis employed is the logistic-fit curve of technology diffusion, c