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Abstract Microalbuminuria is an early sign of diabetic nephropathy. The aim of the present study was to investigate whether the changes of the glomerular filtration barrier in early experimental diabetes are due to size- or charge-selective alterations. Wistar rats, made diabetic by streptozotocin (STZ) and having their blood glucose maintained at approximately 20 mM for 3 or 9 wk, were compared w
Myelodysplastic syndromes and acute myeloid leukemia with an isodicentric X chromosome [idic(X)(q13)] occur in elderly women and frequently display ringed sideroblasts. Because of the rarity of idic(X)(q13), little is known about its formation, whether a fusion gene is generated, and patterns of additional aberrations. We here present a SNP array study of 14 idic(X)-positive myeloid malignancies,
The Chinese-led Asian Infrastructure Investment Bank (AIIB) started operation in January 2016 in the context of severe criticism from the U.S. government and transnational civil society organizations, but with the support from major Asian and European states. The establishment of this new global governance institution (GGI) raises intriguing questions concerning legitimacy and (de)legitimation. Wh
We review our recent studies of excited state structures and dynamics of chemical and biological systems with pico- and femtosecond X-ray absorption spectroscopy in the liquid phase.
This paper presents a qualitative questionnaire study of brand-specific visual product design in the automotive sector. The purpose of the study was to explore the visual product experience of automobile design as perceived by the general public and to analyse those experiences using an emerging framework for visual product experience; VPE. In the study; respondents were asked to assess the design
While scholars commonly assume that Global Governance Institutions (GGIs) need legitimacy to perform effectively, there are few systematic empirical studies assessing the consequences of legitimacy (or the lack thereof) for the functioning of GGIs. Inspired by the new institutionalism in organization theory, which predicts that more legitimate organizations will get more resources than illegitimat
The effect of alcohol intake on varicose veins (VV) has not been determined by its consumption level. The aim of this study was to investigate the association between alcohol intake and VV in an elderly general population. Using a cross-sectional approach, the Shimane CoHRE Study data, comprising a total of 1060 participants, were analyzed. By multivariate regression analysis adjusted with basic c
Background and objectives: Despite global warming, the climate in Northern Europe is generally cold, and the large number of deaths due to non-optimal temperatures is likely due to cold temperatures. The aim of the current study is to investigate the association between cold temperatures and all-cause mortality, as well as cause-specific mortality, in Tallinn and Riga in North-Eastern Europe. Mate
BACKGROUND: There is growing evidence for a negative impact of traffic-related air pollution on risk of dementia. However, the contribution of noise exposure to this association has been rarely examined.OBJECTIVE: We aimed to investigate the individual and combined effect of noise and air pollution on risk of dementia.METHODS: Data on dementia incidence over a 15 year period was obtained from the
The article is devoted to an analysis of legal acts of the Republic of Uzbekistan on counteraction against corruption. The article provides the classification and review of the anti-corruption legislation of Uzbekistan. The article also deliberates about the measures taken by Uzbekistan to implement relevant international legal standards into the national legal system. It considers not only the le
Public transport is an important part of the transition to a more sustainable future. The increasingly market-oriented public transport companies today market themselves with a wealth of messages in multiple channels such as direct mail, websites and apps. This communication is part of the influence that the (potential) traveler is exposed to, yet little research and testing is carried out in orde
Developing a place into ‘a good place to live’ for people of all ages is a prioritized issue in many municipalities in Sweden, as well as around the world. But what do we really mean by ‘a good place to live’? How do the residents themselves comprehend and perceive ‘a good place to live’? And how do municipalities view their place and what they offer to their residents? This thesis explores how ‘a
Neuropeptide Y (NPY) is a powerful vasoconstrictor in vivo but is usually much less active on isolated blood vessels. The contractile effect of NPY was examined in the isolated rat femoral artery exposed to various degrees of vasoconstriction. The effects of NPY on the relaxation induced by vasodilator agents was also studied. NPY (< or = 1 microM) had no contractile effect. In vessels pretreated
MLL rearrangements are translocation mutations that cause both acute lymphoblastic leukemia and acute myeloid leukemia (AML). These translocations can occur as sole clonal driver mutations in infant leukemias, suggesting that fetal or neonatal hematopoietic progenitors may be exquisitely sensitive to transformation by MLL fusion proteins. To test this possibility, we used transgenic mice to induce
