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Chronic care manages long-term, progressive conditions, while acute care addresses short-term conditions. Chronic conditions increasingly strain health systems, which are often unprepared for these demands. This study examines the burden of conditions requiring acute versus chronic care, including sequelae. Conditions and sequelae from the Global Burden of Diseases Study 2019 were classified into
Water scarcity is a dynamic condition influenced by a variety of factors, including environmental variables but also political, economic, technological, and social variables. This research reflects the intersection of natural resources, governance, and human systems. Redefining water scarcity is a crucial factor for greater sustainable management in the face of increasing climate variability and g
Context. Near-infrared high-resolution échelle spectrographs unlock access to fundamental properties of exoplanets, from their atmospheric escape and composition to their orbital architecture, which can all be studied simultaneously from transit observations. Aims. We present the first results of the newly commissioned ESO near-infrared spectrograph, Near-InfraRed Planet Searcher (NIRPS), from thr
Astrocytes play a crucial role in the onset and progression of amyotrophic lateral sclerosis (ALS), a fatal disorder marked by the degeneration of motor neurons (MNs) in the central nervous system. Although astrocytes in ALS are known to be toxic to MNs, the pathological changes leading to their neurotoxic phenotype remain poorly understood. In this study, we generated human astrocytes from induce
The ALICE Collaboration at the CERN LHC has measured the inclusive production cross section of isolated photons at midrapidity as a function of the photon transverse momentum (pTγ), in Pb–Pb collisions in different centrality intervals, and in pp collisions, at centre-of-momentum energy per nucleon pair of sNN=5.02 TeV. The photon transverse momentum range is between 10–14 and 40–140 GeV/c, depend
Toxin-antitoxin-chaperone (TAC) systems are three-part gene clusters encoding a toxin, antitoxin, and specialized SecB-like chaperone (SecB TA) with emerging roles in phage defense. To identify and classify SecB homologs and associated TACs across bacteria, we surveyed the full RefSeq database. Phylogenetic and gene neighborhood analyses reveal three major SecB subfamilies: two housekeeping group
Economic policy instruments are commonly used to address environmental problems. This study examines the historical development of the carbon tax in Sweden. By using the concept of epistemic culture, this study shows how carbon emissions, rather than energy use alone, emerged as an object of taxation. While the leading politicians saw the carbon tax as an innovative instrument for demonstrating cl
The concept of bricolage has primarily been used in exploring how entrepreneurs in the formal sector, in addition to social entrepreneurs, mobilise resources in developing their businesses. Little is known, however, about the bricolage experiences of young informal entrepreneurs in the rapidly changing, technologically driven mobile telephony sector. Drawing on qualitative field research with youn
The modified fighting hypothesis (MFH) proposes that most humans are right-handed because it conveyed an advantage during intraspecific fights with sharp weapons, due to the leftward location of the heart and aorta. An examination of the literature on sharp force injury showed that the thoracic region is penetrated more than any other region, and the left thorax is penetrated approximately 2.4 tim
The ability to overcome short-term economic stress has been shown to be a good measure of the standard of living of populations in the past. From micro-level studies conducted across Europe and Asia we have learned that measures taken to smooth consumption, such as delaying births and marriages, and out-migration, were not sufficient to prevent all family members from dying in years with high food
Introduction: Benchmarking colorectal surgery outcomes informs quality improvement. The ESCP CORREA 2022 snapshot audit aimed to assess contemporary colorectal resection practices and short-term outcomes across European countries and beyond. Methods: An international prospective multicentre audit was conducted in which adults undergoing elective or emergency colorectal resection during a 6-week pe
This study tests the viability of multiple sorting tasks (MST) as a method to explore perceptions of public space and its potential for people that are vulnerable to loneliness. The procedure integrates qualitative and quantitative aspects and obviates the challenge of people articulating how they interact with their surroundings, especially being aware of what features of their environment are in
This study investigates the impact of a 10-week Arts on Prescription (AoP) program in Denmark designed for young adults aged 18–30 who were disengaged from education and unemployed. Eighteen participants took part in four semi-structured focus group interviews, and four completed a survey; most reported experiences of anxiety, depression, and stress, with some describing chronic pain, ADHD, or aut
Serglycin (SRGN) has been found overexpressed and secreted in glioblastoma (GBM), associated with tumorigenic signaling and poor prognosis. In this study, we aimed to elucidate the involvement of SRGN in the unfolded protein response (UPR), an oncogenic signaling pathway implicated in protein recycling and cell fate. Herein, we developed stably transduced LN-18shSCR GBM cells, expressing high leve
The exploration of tunable superconductivity in strongly correlated electron systems is a central pursuit in condensed matter physics, with implications for both fundamental understanding and potential applications. The Laves phase CeRu2, a pyrochlore compound, exhibits a three-dimensional (3D) kagome lattice type geometry giving rise to flat bands and degenerate Dirac points, where band structure
The interplay between superconductivity and charge or spin order is a key focus in condensed matter physics, with kagome lattice systems providing unique insights. The kagome superconductor LaRu3Si2 (Tc ≃ 6.5 K) features a characteristic kagome band structure and a hierarchy of charge order transitions at Tco,I ≃ 400 K and Tco,II ≃ 80 K, along with an additional transition at T* ≃ 35 K associated
The two-dimensional kagome lattice is an experimental playground for novel physical phenomena, from frustrated magnetism and topological matter to chiral charge order and unconventional superconductivity. A newly identified kagome superconductor, Ta2V3.1Si0.9 has recently gained attention for possessing a record high critical temperature, TC = 7.5 K for kagome metals at ambient pressure. In this s
Purpose: The study aimed to describe patients’ experiences of physical, psychological, social, and existential symptoms and challenges during the first year after allogeneic haematopoietic cell transplantation (allo-HCT). Methods: Quantitative and qualitative data were collected and analysed with descriptive methods as part of a large retrospective cross-sectional online survey of patients who und
