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The X-ray flux from X-ray free-electron lasers and storage rings enables new spatiotemporal opportunities for studying in-situ and operando dynamics, even with single pulses. X-ray multi-projection imaging is a technique that provides volumetric information using single pulses while avoiding the centrifugal forces induced by conventional time-resolved 3D methods like time-resolved tomography, and

Ferroelectric thin films present a powerful platform for next-generation computing and memory applications. However, domain morphology and dynamics in buried ferroelectric stacks have remained underexplored, despite their importance for real device performance. Here, nanoprobe X-ray diffraction (nano-XRD) is used to image ferroelectric domains inside BiFeO3-based capacitors, revealing local disord

The PRIMARY score was implemented in Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE) version 2 to improve accuracy for the diagnosis of clinically significant prostate cancer using prostate-specific membrane antigen (PSMA) positron emission tomography (PET). We reviewed overall survival (OS) for patients who underwent PSMA PET for initial staging to evaluate the prognostic valu

Only one fifth of children aged 11–17 years are physically active for 60 min (min)/day. As physical activity (PA) levels track from childhood to adulthood, it is important to establish healthy PA behavior early in life. This study aims to evaluate whether daily school PA is associated with objectively measured PA independently of other socioecological factors. This study includes 209 children (120

Importance Tracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information is available on adverse peri-intubation events.Objective To evaluate the incidence and nature of adverse peri-intubation events and to assess current practice of intubation in critically ill patients.Design, Setting, and Participants The International

Objectives Early diagnosis and timely treatment are key elements of a successful healthcare system. We assessed the role of socioeconomic and cultural norms in accelerating or decelerating uptake and utilisation of health technologies into policy and practice. Setting Secondary and tertiary level healthcare facilities (HCFs) in three East African countries. Level of HCF was selected based on the W

Sensitivity, specificity, and agreement between clinical and magnetic resonance imaging (MRI) gradings of the medial collateral ligament (MCL) after acute knee injury were evaluated in 362 patients. Ninety-seven per cent were injured during sports/recreation. Sensitivity and specificity of MRI for grade II or III MCL injury was 68% (95% CI 58–77%) and 90% (95% CI 86–93%), respectively. Weighted Ka

Evaluation of a complex healthcare intervention should include careful exploration of the mechanisms through which it brings about change. This paper describes a qualitative evaluation of the Redesigning Daily Occupations (ReDO®-10) programme as it was implemented for the first time with women with stress-related issues in a primary care setting in Ireland. The ReDO®-10 is a 10-week group interven

The X-ray flux provided by X-ray free-electron lasers and storage rings offers new spatiotemporal possibilities to study in-situ and operando dynamics, even using single pulses of such facilities. X-ray Multi-Projection Imaging (XMPI) is a novel technique that enables volumetric information using single pulses of such facilities and avoids centrifugal forces induced by state-of-the-art time-resolv

Introduction: Antimicrobial resistance (AMR) represents a persistent and ascensive global threat influenced by antibiotic misuse and overuse. In the Romanian context, patterns of antibiotic consumption and resistance within the healthcare system are marked in the red scenario on the European map. General practitioners and pharmacists, among others, play a major role in stewardship towards AMR.Aim:

BACKGROUND AND AIM: Cigarette smoking is the most common cause of chronic obstructive pulmonary disease (COPD) but more mechanistic studies are needed. Cigarette smoke extract (CSE) can elicit a strong response in many COPD-related cell types, but no studies have been performed in lung fibroblasts. Therefore, we aimed to investigate the effect of CSE on gene expression in lung fibroblasts from hea

Compositional heterogeneity is commonly observed in mixed bromide/iodide perovskite photoabsorbers, typically with minimal effects on charge carrier recombination and photovoltaic performance. Consistently, it has so far received very limited attention in bromide/chloride-mixed perovskites, which hold particular significance for blue light-emitting diodes. Here, we uncover that even a minor degree

Lakes with increased water colour levels have been observed in many locations in the northern hemisphere, a phenomenon that is called brownification. The driving components of brownification are dissolved organic matter (DOM) and iron, which are affected by rainfall patterns as a large fraction originates from terrestrial sources. Brownification has many detrimental effects for the ecosystem, amon

We are at what appears to be an impasse. Almost everyone across the world – and certainly in the west – has heard of climate change and knows at least a bit about what it means. Yet dominant norms, values and behaviours in the human-ecological relationship still persist, despite the fact that many of these are agreed to be the very source of the problem. Finding a way – or more accurately, ways –

This study focuses on the intrinsically disordered regulatory domain of p53 and the impact of post-translational modifications. Through fully atomistic explicit water molecular dynamics simulations, we show the wealth of information and detailed understanding that can be obtained by varying the number of phosphorylated amino acids and implementing a restriction in the conformational entropy of the

Bragg coherent X-ray diffraction imaging (BCDI) has emerged as a powerful technique for strain imaging and morphology reconstruction of nanometre-scale crystals. However, BCDI often suffers from angular distortions that appear during data acquisition, caused by radiation pressure, heating or imperfect scanning stages. This limits the applicability of BCDI, in particular for small crystals and high

Young people have been prominent climate advocates globally and they are also becoming increasingly visible in global climate politics. They have participated in Conferences of the Parties (COPs) to the United Nations Framework Convention on Climate Change (UNFCCC) since COP1 in 1995. While recent studies have started to examine the representativeness and participation of youth at the COPs, we sti

The decline in areal BMD (aBMD) in men may start as early as age 19, but it is debated whether proximal femoral strength follows the same pattern. We measured FN aBMD in a cross-sectional cohort of 1101 men aged 18-28 yr with two-dimensional DXA. Body height, weight, jump height, grip strength, and maximum knee extension torque muscle strength were measured with standard tests, after which BMI was