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The discovery of the role of α-synuclein in the pathogenesis of Parkinson's disease (PD) has opened new possibilities for the development of more authentic models of Parkinson's disease. Recombinant adeno-associated virus (AAV) and lentivirus (LV) vectors are efficient tools for expression of genes locally in subsets of neurons in the brain and can be used to express human wild-type or mutated α-s
Soil phosphorus (P) composition changes with ecosystem development, leading to changes in P bioavailability and ecosystem properties. Little is known, however, about how soil P transformations proceed with ecosystem development in boreal regions. We used 1-dimensional P-31 and 2-dimensional H-1, P-31 correlation nuclear magnetic resonance (NMR) spectroscopy to characterise soil organic P transform
Septic tanks with subsequent soil treatment systems (STS) are a common treatment technique for domestic wastewater in rural areas. Phosphorus (P) leakage from such systems may pose a risk to water quality (especially if they are located relatively close to surface waters). In this study, six STS in Sweden (11-28 years old) were examined. Samples taken from the unsaturated subsoil beneath the distr
Ciliate assemblages play a significant role in the microbial food web. The effects of environmental temperature on assemblage composition may be influenced by abiotic factors such as seasonality and disturbance, but the effects of temperature on ciliate assemblages found on different substrata have not been explored. Sandy bottoms and submerged rocks harbour dissimilar ciliate assemblages, and it
Pollination contributes to an estimated one third of global food production, through both the improvement of the yield and the quality of crops. Volatile compounds emitted by crop flowers mediate plant-pollinator interactions, but differences between crop varieties are still little explored. We investigated whether the visitation of crop flowers is determined by variety-specific flower volatiles u
The critical levels for ozone effects on vegetation have been reviewed and revised by the LRTAP Convention. Eight new or revised critical levels based on the accumulated stomatal flux of ozone (POD gamma, the Phytotoxic Ozone Dose above a threshold flux of Y nmol m(-2) PLA s(-1), where PLA is the projected leaf area) have been agreed. For each receptor, data were combined from experiments conducte
Large plants are often more conspicuous and more attractive for associated animals than small plants, e.g. due to their wider range of resources. Therefore, plant size can positively affect species richness of associated animals, as shown for single groups of herbivores, but studies usually consider intraspecific size differences of plants in unstandardised environments. As comprehensive tests of
The integrated model WORLD and Hubbert's model were used for assessment of future supply for different metals: iron, nickel, manganese, chromium, molybdenum, tantalum, niobium, rhenium, zir- conium, tungsten, cobalt, copper, zinc, lead, aluminium and the technology metals derived from copper ezinc mining (tellurium, selenium, gallium, indium, antimony, bismuth, tin, germanium, selenium). The conne
The properties of iron (Fe) complexes and compounds in the environment influence several central processes, e.g., iron uptake, adsorption/desorption of contaminants and nutrients, and redox transformations, as well as the fate of of natural organic matter (NOM). It is thus important to characterize Fe species in environmental samples. Synchrotron-based extended X-ray absorption fine structure (EXA
In Sweden, migrants suffer from poorer sexual and reproductive health than the general population due to exposures associated with pre- and post-migration process and difficulties that arise when meeting a new heath system. Health literacy is a term that is increasingly used for explaining people’s access to health preventive services, and where migrant populations has shown to possess lower level
Coastal protection has evolved from focusing on hard solutions such as breakwaters and groynes to include soft or nature-based solutions (NbS). NbS have been pro- posed as cost-effective means to offer long-term coastal protection and at the same time strengthen coastal resilience and biodiversity. However, projects utilizing NbS for coastal protection have often focused on a single solution and t
The European Union's Common Agricultural Policy (CAP) has not halted farmland biodiversity loss. The CAP post-2023 has a new ‘‘Green Architecture,’’ including the new ‘‘Eco-scheme’’ instrument. How can this new Green Architecture help tackle the biodiversity crisis? Through 13 workshops and an online survey, over 300 experts from 23 European Member States addressed this question. From experts’ con
Savannas cover a wide climatic gradient across large portions of the Earth’s land surface and are an important component of the terrestrial biosphere. Savannas have been undergoing changes that alter the composition and structure of their vegetation such as the encroachment of woody vegetation and increasing land-use intensity. Monitoring the spatial and temporal dynamics of savanna ecosystem stru
Vapor pressure deficit (VPD) is of great importance to control the land-atmosphere exchange of water and CO2. Here we use in situ observations to assess the performance of monthly VPD calculated from state-of-the-art data sets including CRU, ERA5, and Modern-Era Retrospective analysis for Research and Applications, Version 2 (MERRA2). We investigate trends in VPD at global scale and for different
Autonomous driving has become an important research area for road traffic, whereas testing of autonomous driving systems to ensure a safe and reliable operation remains an open challenge. Substantial real-world testing or massive driving data collection does not scale since the potential test scenarios in real-world traffic are infinite, and covering large shares of them in the test is impractical
Sexual dysfunction after allogeneic hematopoietic cell transplantation (allo-HCT) is a common long-term complication. We conducted a European multicenter cross-sectional study of adult allo-HCT recipients who had survived >2 years and their partners to investigate sexual functioning after HCT and to evaluate whether discussion about sexual functioning between the transplant team and the survivor a
Microplastics provide a new ecological niche for microorganisms, and the accumulation levels of microplastics (MPs) in terrestrial ecosystems are higher than those in marine ecosystems. Here, we applied the zymography to investigate how MPs — polyethylene [PE], and polyvinyl chloride [PVC]) at two levels (0.01% and 1% soil weight) impacted the spatial distribution of soil hydrolases, nutrient avai
Intrinsically disordered proteins (IDPs) have a broad energy landscape and consequently sample many different conformations in solution. The innate flexibility of IDPs is exploited in their biological function, and in many instances allows a single IDP to regulate a range of processes in vivo. Due to their highly flexible nature, characterizing the structural properties of IDPs is not straightforw
