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Popular Abstract in Swedish Blodgruppsantigen finns på den röda blodkroppens cellyta och även på många andra celltyper. I denna avhandling har jag studerat gener och dess varianter (polymorfismer) som är ansvariga för uttrycket av tre blodgruppsantigener av kolhydratnatur, nämligen Pk, P och P1. Dessa utgör P- och GLOB-blodgruppssystemen och GLOB-kollektionen. Fem olika fenotyper förekommer då anThe clinically important carbohydrate P/GLOB blood group systems and collection give rise to both common (P1, P2) and rare (p, P1k, P2k) blood group phenotypes. The associated antibodies are implicated in severe transfusion reactions and recurrent spontaneous abortions. The aim of this study was to explore the molecular genetic basis of Pk, P and P1 antigen expression. Sequence analysis of the A4

Repair and reconstruction of major nerve trunks in the upper extremity is a very challenging surgical problem. Today, there is no surgical repair technique that can assure recovery of tactile discrimination in the hand of an adult patient following nerve repair. In contrast, young individuals usually attain a complete recovery of functional sensibility. The outcome from nerve repair depends mainly

Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS) which is thought to arise from a breakdown of immunological tolerance in CD4 cells. The aim of this thesis is to improve our understanding of regulation mechanisms of T cell-dependent chronic inflammation in the CNS and explore ways to overcome the onset and progression of the disease, which can be an importa

Osteoarthritis (OA) and pigmented villonodular synovitis (PVNS) are disorders associated with trisomy 7. The aim of the present study was to determine the frequency and distribution of the cells with +7 in vivo by analyzing sections of paraffin-embedded synovia from patients affected by OA, PVNS, other forms of synovitis [hemorragic synovitis (HS) and chronic synovitis (CS)], and from individuals

Autoimmune diseases such as rheumatoid arthritis (RA) are chronic diseases that cannot be prevented or cured. If the pathologic basis of such diseases would be known, it might be easier to develop new drugs interfering with critical pathways. Genetic analysis of animal models for autoimmune diseases can result in discovery of proteins and pathways that play a key function in pathogenesis, which ma

OBJECTIVE: The underlying mechanisms of the differences in sex distribution of patients with atrioventricular (AV) nodal re-entrant tachycardia and Wolff-Parkinson-White syndrome are poorly understood. The objective of this study was to determine potential gender differences in the electrophysiological properties of the normal AV conduction system that may be attributable to differences in sex dis

Popular Abstract in Swedish Det är välkänt att övervikt och fetma är starkt associerade med sjukliga förändringar i hjärtkärlsystemet och ökar risken att drabbas av hjärtkärlsjukdom och förtida död. Trots att viktnedgång hos överviktiga kan leda till en tillbakagång av sjukliga förändringar i hjärta och kärl, har man dock inte klart visat att viktnedgång leder till minskad risk att drabbas av hjärHigh body mass index (BMI) is associated with cardiovascular risk factors such as hypertension, dyslipidemia, and insulin resistance. Obesity is also an independent risk factor for coronary artery disease (CAD) and can cause structural as well as functional changes in the heart. High BMI is associated with increased mortality in the population. Weight-loss from a state of overweight or obesity may

Many studies have supported a genetic etiology for autism. Here we report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders. These mutations affect cell-adhesion molecules localized at the synapse and suggest that a defect of synaptogenesis may predispose to autism.

Breast carcinoma is thought to arise because of multiple successive changes in the genome of the normal epithelial cells. However, little is known of the order of appearance of different types of genetic aberrations We studied the ERBB2 (Her-2/neu) and CCND1 (cyclin D1) oncogene amplification in flow cytometrically sorted diploid and nondiploid tumor cell populations by fluorescence in situ hybrid

Poverty reduction, first on the list of Millennium Development Goals, requires access to modernized, stable energy to be realized. Rural areas are especially vulnerable, which is why renewable energy technologies (RETs) illustrate a promising solution for modernized energy access. Entrepreneurs play an important role in these sustainable development projects by helping build up an entire sector of

This study examines the long-term post-acquisition performance of acquirers, both serial and single, in Sweden within a time frame spanning from 2000 to 2022. The post-acquisition performance is evaluated using a long-term event study, employing the Buy-and-Hold Abnormal Returns (BHAR) methodology. The results of the 1-year BHAR analysis indicate that, on average, Swedish acquirers exhibit abnorma

This thesis investigates the business model and technology ecosystem of Ant Group, focusing on their flagship product, Alipay. It examines how Ant Group has leveraged its business model and technology ecosystem to achieve success in the financial services industry. The research encompasses a literature review on technology ecosystems, paths of influence in technological evolution, and Ant Group

Diet-related diseases kill millions of people every year and pose significant costs to the economy and society. In Sweden, this is an increasingly prevalent phenomenon. However, a healthy diet can prevent this. This thesis investigates what costs and benefits there are to adopting healthy eating habits and how these effects impact the Swedish economy. This thesis finds that the costs and benefits

Examensarbetets titel: What’s the name of the game? – Om resultatjustering när mandaten står på spel – En kvantitativ analys om hur valcykeln påverkar resultatjusteringen i svenska kommuner. Seminariedatum: 2 Juni 2023 Kurs: FEKH69, Examensarbete i redovisning på kandidatnivå, 15 hp Författare: Julia Jankovic, Mari-Ling Komber, Linnéa Petersson Handledare: Mattias Haraldsson Fem nyckelord: Resulta

The current paper aims to explore the psychometric properties of two public domain cognitive ability scales, Cog15 and ICAR16, and investigate how well they each capture the g-factor in a Swedish sample (N = 428). The motivation for choosing these aims is that public domain, free, and easily accessible intelligence tests are needed for measuring the g-factor. Principal components analysis (PCA), c

Title: Stickering of Food Products at IKEA–Improving a Process Through Learning from Others; Increasing process maturity to ensure future performance Authors: John Nyqvist and Victoria Vernet Supervisors: Eva Berg, Department of Industrial Management and Logistics, Faculty of Engineering, Lund University Problem description: Stickering has been used at IKEA for a long time to create compliant f

Global post-industrial cities face the dual challenge of sustaining growth while repairing damaged ecosystems. Industrialization has left profound scars on both ecological networks and the urban fabric, demanding systematic spatial regeneration and environmental repair. Among these, abandoned brownfields hold unique potential: they offer opportunities to reshape urban structures, restore ecologica

With the adoption of the New Pact on Migration and Asylum, the European Union (EU) and its Member States are encouraged to cooperate with third States through informal agreements, notably in the form of Memoranda of Understanding (MoUs). These arrangements form a central component of the EU’s externalisation strategy, shifting its borders outwards and thereby limiting the circumstances under which