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Popular Abstract in Swedish Kroniskt Obstruktiv Lungsjukdom (KOL) är idag världens fjärde vanligaste dödsorsak vars dödlighetsfrekvens ökar. KOL är en lungsjukdom som nästan alltid beror på rökning och i hela världen är cirka 600 miljoner människor drabbade av sjukdomen. Detta gör KOL till världens vanligaste kroniska sjukdom. I Sverige beräknas sjukvårdskostnaderna för KOL att uppgå till ca 9,1 mProteomic analysis of bronchoalveolar lavage (BAL) fluid from smokers at risk of developing chronic obstructive pulmonary disease (COPD) and never smokers is described. COPD is currently the world's fourth leading cause of death and its prevalence is increasing. The leading cause of COPD is smoking and an estimated 600 million people in the world suffer from COPD which makes it the world's most co

Model systems have shown that adenoviral vector mediated transient gene expression can potentially be applied for the treatment of brain tumours, neurodegenerative diseases and brain injuries. Most studies utilized adenovirus serotype 5 (Ad5) based vectors, which as adhesion molecules require the coxsackie adenovirus receptor (CAR) as a critical determinant for cellular infection. In this report,

Extravasated endogenous serum albumin and fibrinogen were identified immunohistochemically in coronal brain sections from normotensive Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) after permanent ligation of the right middle cerebral artery. Infarcts were seen in all the SHR but only in 6 out of 14 WKY. Six hours after ligation, extravasated proteins were located primarily wit

An understanding of the distribution of water in wood pulp during drying is of fundamental importance to the paper industry. In this study nuclear magnetic resonance (NMR) imaging is used to measure quantitative water profiles during the drying of liquid packaging board with initial water ratio (water: dry mass) of approximately 1.5. The drying was carried out in situ within the magnet, under a ra

Ferrans and Powers’ Quality of Life Index (QLI) defines and assesses quality of life (QoL) in terms of importance-weighted life satisfaction. This study assessed the value of such weights and explored the relationship between weighted and unweighted (satisfaction only) scores and single-item rated overall life satisfaction (LS) and QoL. Data were collected by a postal survey to 81 Parkinson’s dise

Popular Abstract in Swedish Dålig ergonomi i produktionssystem kan äventyra prestationsförmågan och även orsaka muskuloskeletala besvär (eng. musculoskeletal disorders: MSD). Detta utgör en stor kostnad för samhälle, företag och drabbade individer. Denna avhandling presenterar en forskningsansats att 1) identifiera och kvantifiera arbetsplatsens riskfaktorer för MSDs, 2) identifiera hur dessa riskPoor ergonomics in production systems can compromise performance and cause musculoskeletal disorders (MSDs), which pose a huge cost to society, companies, and afflicted individuals. This thesis presents a research trajectory through the problem space by: 1) Identifying and quantifying workplace risk factors for MSDs, 2) Identifying how these risks may relate to production strategies, and 3) Develo

Softwood is an interesting raw material for the production of fuel ethanol as a result of its high content of hexoses, and it has attracted attention especially in the Northern hemisphere. However, the enzymatic hydrolysis of softwood is not sufficiently efficient for the complete conversion of cellulose to glucose. Since an improvement in the glucose yield is of great importance for the overall e

Popular Abstract in Swedish Denna studie är ämnad åt att undersöka joniseringsprocessen i gaser, både teoretiskt och experimentellt. Arbetet är speciellt riktat mot att utöka förståelsen för detta fenomen i förbränningsrummet av en förbränningsmotor. Den intensiva joniseringsprocessen som uppstår till följd av den antändande gnistan har studerats såväl som den svagare joniseringsprocessen som är rThe processes that govern the formation, existence and consumption of ions in gases have been studied both experimentally and theoretically. The aim of the work is targeted at increasing the understanding of these phenomena in the working gases inside an engine. Both the cause and the application of ionized gases inside the cylinder of a spark ignited (SI) engine has been studied. The spark disch

Background: The early diastolic downward slope (EDS) of the left atrioventricular plane displacement (AVPD) is a parameter of early left ventricular (LV) diastolic filling, particularly useful in revealing pseudonormalisation of the transmitral Doppler early to atrial (E/A) ratio. In recent studies LV early diastolic function seems to be closely linked to LV systolic function. In order to further

The aim of this work was to evaluate the measurement properties and hierarchical item structure of the Epworth Sleepiness Scale (ESS) in patients with Parkinson's disease (PD). Data were taken from a cross-sectional study regarding fatigue and sleep-related aspects of PD. One hundred and eighteen consecutive patients with neurologist-diagnosed PD without significant co-morbidities (54% men; mean a

The timing of reproduction in birds varies considerably within populations and is often under strong natural selection. Individual timing within years is dependent on a range of environmental factors in addition to having an additive genetic basis. In vertebrates, an increasing amount is known about the molecular basis for variation in biological timing. The Clock gene includes a variable poly-glu

Antimuscarinic drugs are generally thought to exert their therapeutic action on detrusor overactivity by reducing the ability of the detrusor muscle to contract. We review currently available published data to establish whether there is any evidence to support this contention. Using a PubMed data search, only 14 original articles (including two abstracts) were found that contained cystometric data

Tailored supercritical carbon dioxide (scCO(2)) extraction of alkyhesorcinols (ARs) from rye bran resulting in pre-purification of ARs already during extraction process. The pre-purification was achieved by splitting the extraction process in 2 steps.. In both steps, the CO2 pressure was set at 25 MPa with a flow rate of 10 g/min. The first step was carried out at 70 degrees C. 0.06% of ethanolic

The aim of this study was to assess the impact of the degree of difficulty and quality of hernia repair, as perceived by the surgeon, and operative time on the reoperation rate. All hernia repairs performed during the period 1994-1995 at the Department of Surgery, University Hospital of Lund, Sweden, were recorded prospectively. The degree of difficulty and the degree of difficulty in relation to

Glacontryphan-M, a novel calcium-dependent inhibitor of L-type voltage-gated Ca2+ channels expressed in mouse pancreatic beta-cells, was recently isolated from the venom of the cone snail Conus marmoreus (Hansson, K., Ma, X., Eliasson, L., Czerwiec, E., Furie, B., Furie, B. C., Rorsman, P., and Stenflo, J. ( 2004) J. Biol. Chem. 278, 32453-32463). The conserved disulfide-bonded loop of the contryp

Maternally derived androgens have been shown to influence offspring phenotype in various ways. In birds, the benefits of prenatal androgen exposure, such as increased competitiveness and accelerated growth in nestlings, have been suggested to be balanced by costs, such as reduced immune function. In this study, we used an integrative approach to examine the influence of yolk androgens on the devel

Type 2 diabetes (T2D) is a progressive disorder with a consistent and steady increase in glycosylated hemoglobin (HbA1c) over time associated with enhanced risk of micro- and macrovascular complications and a substantial reduction in life expectancy. There are three major pathophysiologic abnormalities associated with T2D: impaired insulin secretion, excessive hepatic glucose output, and insulin r