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The conventional indirect immunofluorescence test of islet cell antibodies was recently improved by the development of a two-colour immunofluorescence assay using a monoclonal proinsulin antibody to detect islet B cells. The aim of this study was to test whether in this new assay the prevalence and titre of ICA were affected by the time of incubation carried out in the presence of aprotinin (Trasy
Pancreatic islets from A.TH mice were transplanted into the spleen or streptozotocin (SZ)‐diabetic A.TL mice. The two strains of mice are congenic inbred strains, differing only in the I and S subregions of the H‐2 complex. The allogeneic islet grafts decreased blood glucose temporarily, but the islets were rejected after 21 ± 7 days (mean ± SD). The effect of skin presensitization was tested by g
The ontogenetic developments of the pineal organ, parapineal organ, and retina were studied by the use of light and electron microscopy in embryos and fry of the teleost, Gasterosteus aculeatus, from 60 to 168 h after fertilization. Sixty to 66 h after fertilization, the primordium of the pineal complex is discernible in the diencephalic roofplate; the parapineal anlage is located rostral to the p
Si fluxes from the continents to the ocean are a key element of the global Si cycle. Due to the ability of coastal ecosystems to process and retain Si, the ‘coastal filter’ has the potential to alter Si fluxes at a global scale. Coastal zones are diverse systems, sensitive to local environmental changes, where Si cycling is currently poorly understood. Here, we present the first palaeoenvironmenta
This study investigates the growth in global renewable energy use between 2000 and 2014. To identify its main contributors and their geographical distribution, a structural decomposition analysis is applied to global multi-regional input-output tables. A new variant of this type of analysis is developed that introduces energy transition (i.e. the substitution of non-renewable energy by renewable e
The 1st International Hip-related Pain Research Network meeting discussed four prioritised themes concerning hip-related pain in young to middle-aged adults: (1) diagnosis and classification of hip-related pain; (2) patient-reported outcome measures for hip-related pain; (3) measurement of physical capacity for hip-related pain; (4) physiotherapist-led treatment for hip-related pain. Thirty-eight
The chapter integrates physicalist and constructivist approaches to phenomena conventionally categorised as ‘labour’ and ‘energy’ by unravelling how the two entangled concepts reflect nineteenth-century modernity’s increasingly instrumental approach to both society and nature. Energy technologies became understood as the efficient harnessing of nature’s powers in much the same way as economists fo
Based on data from three surveys of the vascular flora of the province of Scania, southernmost Sweden, conducted 1938–1971, 1987–2006 and 2008–2015, we analyse the change in frequency of individual species and groups of species associated with particular vegetation types. A majority of all species have experienced a change in frequency since 1938, and this turnover has continued in recent decades.
Rivers discharge a notable amount of dissolved Fe (1:5×109 mol yr-1) to coastal waters but are still not considered important sources of bioavailable Fe to open marine waters. The reason is that the vast majority of particular and dissolved riverine Fe is considered to be lost to the sediment due to aggregation during estuarine mixing. Recently, however, several studies demonstrated relatively hig
Aims/hypothesis: It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed twin-cycle hypothesis (TC) provides a mechanistic basis for impairment in glycaemic control through the interactions of substrate availability, substrate metabolism and abdominal ectopic fa
To establish the contribution of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) for the incretin effect after oral glucose, studies were undertaken in female mice with genetic deletion of receptors for GIP and GLP-1 (double incretin receptor knockout [DIRKO] mice) and their wild-type (WT) counterparts. Insulin secretion was explored after oral glucose (doses
The objective was to investigate if diffusing laser fibres can be modelled as conductive heat sources without miscalculating coagulated volumes, and if finite element analysis, disregarding light transport, may be used for three dimensional (3D) treatment planning in interstitial laser thermotherapy (ILT). Temperature distributions and coagulated volumes with a diffusing laser fibre, as compared t
The main aims with this book are to compare source materials, databases and research results, as well as creating new opportunities for collaboration in the field of social and population history in the East and the West. All the contributions are based on nominative source material, mainly censuses and vital records, which have been preserved, scanned, transcribed into databases in order to be us
A series of binary quasicrystal approximants RE13Zn 58+δ (RE = Ho, Er, Tm, and Lu) have been prepared, and structural studies were performed by means of single-crystal X-ray diffraction. All four compounds crystallize in the orthorhombic system, but while the Ho-containing compound crystallizes in space group Pcmn, the rest of the compounds crystallize in Pc21n. This work is a continuation of the
The top quark mass is measured using a template method in the tt¯ → lepton + jets channel (lepton is e or μ) using ATLAS data recorded in 2012 at the LHC. The data were taken at a proton–proton centre-of-mass energy of s=8 TeV and correspond to an integrated luminosity of 20.2 fb - 1 . The tt¯ → lepton + jets channel is characterized by the presence of a charged lepton, a neutrino and four jets, t
