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The ubiquitous skin colonist Staphylococcus epidermidis elicits a CD8+ T cell response pre-emptively, in the absence of an infection1. However, the scope and purpose of this anticommensal immune programme are not well defined, limiting our ability to harness it therapeutically. Here, we show that this colonist also induces a potent, durable and specific antibody response that is conserved in human
Gallstone disease is common in the Western world, and approximately 15,000 cholecystectomies and 9000 endoscopic retrograde cholangiopancreatographies (ERCPs) are performed each year in Sweden. While being safe, the high frequency of these procedures has a significant cumulative impact on health in the community, exceeding those of many complex procedures for malignant conditions. Compliance with
Purpose: The Paleolithic Diet Fraction (PDF) estimates the proportion of absolute dietary intake derived from food groups included in the Paleolithic diet. In the Malmö Diet and Cancer Study (MDCS), higher PDF and lower systemic low-grade chronic inflammation (SLGCI) have been associated with lower cardiometabolic morbidity and mortality. We examined associations between PDF and SLGCI in the MDCS.
BACKGROUND AND OBJECTIVES: Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by 3 core symptom complexes: parkinsonism, cerebellar syndrome, and dysautonomia. Recent Movement Disorder Society (MDS) criteria allow for the clinical diagnosis of MSA based solely on motor symptoms, without requiring dysautonomia. This study aimed to evaluate the frequency and disease trajecto
Explicit finite element schemes are extensively used in industrial applications characterised by elevated strain rates and complex contact interactions. A central challenge in such simulations is the achievement of mesh-independent results while accurately capturing damage localisation and evolution. Gradient-enhanced damage models provide a robust regularisation framework. However, using a microm
Background: A novel generation of PET scanners based on silicon (Si)-photomultiplier (PM) technology has recently been introduced. Concurrently, there has been development of new reconstruction methods aimed at increasing the detectability of small lesions without increasing image noise. The combination of new detector technologies and new reconstruction algorithms has been found to increase image
The presence of viral immune triggers at the intestinal mucosa can have multipleglobal effects on intestinal integrity, including relative protection fromsubsequent inflammatory bowel disease. During the last century, the westernworld has achieved a remarkable success in preventing infectious diseases,which increased the general life expectancy dramatically. However, theincidence and prevalence of
Context. The light curves of tidally locked hot Jupiters transiting fast-rotating, early-type stars are a rich source of information about both the planet and star, with full-phase coverage enabling a detailed atmospheric characterisation of the planet. Although it is possible to determine the true spin-orbit angle ψ-a notoriously difficult parameter to measure-from any transit asymmetry resulting
BACKGROUND: Several studies have reported on the use of intraoperative parathyroid hormone (ioPTH) measurements during parathyroidectomy (PTX) for renal hyperparathyroidism (rHPT), but there is no consensus on whether it is helpful and, if so, what protocol should be used. Therefore, the literature was systematically reviewed to assess a correlation between ioPTH and early postoperative parathyroi
Temporally resolved assessment of residential exposure to radon is essential for investigating radon's acute health effects. Recent studies have used large numbers of short-term radon measurements to model the spatiotemporal variations in radon concentrations. However, most short-term radon measurements in the northeastern and midwestern United States were conducted in the basements, which were le
Addressing the housing needs of the displaced communities is an essential part of a recovery programme that has distinct links to livelihoods, health, education, security and social and family stability. The housing factor acts as a social centre for family and friends, a source of pride and cultural identity and a resource that commands both political and economic importance. Therefore, addressin
We explore how team gender composition affects willingness to lead by randomly assigning participants in an experiment to male- or female-majority teams. Irrespective of team gender composition, men are substantially more willing than women to lead their team. The pooled sample, and women separately, are more willing to lead female- than male-majority teams. An analysis of mechanisms reveals that
How do we explain change in political transnationalism over time? In what way does this change affect diasporic identities? And how does this change alter the relationship and power of diasporic actors towards their homeland states? This paper addresses these questions in relation to Iraqi Shi’a political transnationalism between London and Iraq pre and post-2003. I argue that the confluence of po
Ciguatera Poisoning (CP) is caused by consumption of fish or invertebrates contaminated with ciguatoxins (CTXs). Presently CP is a public concern in some temperate regions, such as Macaronesia (North‐Eastern Atlantic Ocean). Toxicity analysis was performed to characterize the fish species that can accumulate CTXs and improve understanding of the ciguatera risk in this area. For that, seventeen fis
How do political parties function abroad? How do political parties mobilize overseas supporters during elections? This chapter focuses on the cases of the Justice and Development Party (AKP) and the Peoples’ Democratic Party (HDP), the two most successful Turkish political parties among emigrants. It compares their distinct organisational structures and mobilisation techniques when seeking to reac
BACKGROUND: In 2013, it was discovered that a subset of the population in Ronneby, Sweden was exposed to high levels of perfluorinated compounds (PFAS) from drinking water that had been provided by the local Brantafors waterworks and was contaminated by fire-fighting foam from a nearby airport. The start and time-course of population exposures are not known.OBJECTIVE: To investigate the start of P
