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A specific class of signaling proteins has been shown to affect adult hematopoiesis in mice, but little is known about the role that these proteins play during hematopoiesis in the fetal liver of the embryo. Here, we have studied and compared the in vitro and in vivo response to a cytokine in bone marrow and fetal liver hematopoietic stem and progenitor cells (HSPCs). We have found that fetal live
This work is an investigation into practical design and loss minimization of DC/DC-switched power supplies, enabling cooler operation, smaller size, and additional or wider areas of use. There is an abundance of switch controller ICs on the market and a few of the manufacturers offer very sophisticated design tools that suggest operating parameters and grade components. However, one of the major
Purpose of this paper: The U.S. and European way of planning road-freight transport are different. These differences pose an interest of analyzing, assessing and evaluating. Transport planning in the U.S. is far more centralized and integrated than in the de-centralized inefficient European way. The aim of this paper is therefore to improve transport planning in Europe by analyzing the U.S. best-p
The Human Right to Science is about the “human right to benefit from progress in science and its applications,” also known more succinctly as the “right to science.” Although the right to science is one of the oldest internationally recognized human rights, it has suffered too long from neglect. International organizations and States pay little attention to it. There are only a few inadequate indi
Tattoo ink on the European market has been reported to contain many human toxicants, which has raised concerns about health effects. Clarifying the exposure distribution in the population is key to understanding potential public health implications. We investigated the prevalence of tattoos in a population-based Swedish cohort of 13 046 individuals aged 20–68 years with exposure data collected thr
Fine-grained windblown deposits (loess) in which fossil soils (palaeosols) are preserved are excellent records of past climate. However, so far paleoclimate reconstruction studies conducted on such loess-palaeosol sequences (LPS) in SE Europe were focused on the climate changes of the last one or two glacial-interglacial cycles, while almost no attention has been directed to the climate of the cur
Background and objective: Although cardiovascular toxicity from modern systemic treatments in metastatic hormone-sensitive prostate cancer (mHSPC) remains a concern, real-world data are limited. We aimed to characterise patients treated for mHSPC across multiple large cohorts and estimate cardiovascular adverse event (AE) risks. Methods: Leveraging PIONEER's Big Data platform, with databases stand
Förlossningen är en omvälvande och minnesvärd livshändelse. Den nyblivna mammans fokus ligger på det nyfödda barnet, likaså vårdpersonalens. En förlossning kan leda till allvarliga skador på bäckenbotten (pelvic floor, PF), ibland med komplikationer som inkontinens. Tyvärr förbises eller tonas dessa skador ofta ned – både av nyblivna mödrar och vårdgivare. I Sverige drabbas ungefär 1–4% av kvinnorGiving birth is a profound life event. Most of the time, mothers move their attention to their newborn, as do healthcare providers. Childbirth can cause severe pelvic floor (PF) injuries, potentially leading to complications, such as incontinence. Despite their impact, these injuries are often deprioritised or normalised—both by postpartum women and healthcare providers. In Sweden, 1–4% of women w
Flat bands can induce strong electron correlation effects that help stabilize both magnetic and superconducting states. Here, we carry out angle-resolved photoemission spectroscopy and density functional theory calculations to study the electronic structure of the Co-pnictides CaCo2As2 and LaCo2P2. We find that the kz Fermi topology of ferromagnetic LaCo2P2 is markedly two-dimensional, while the a
Avian malaria parasites pose a significant threat to conservation, affecting populations worldwide. Despite this, our understanding of factors influencing the transmission of avian Plasmodium parasites by vectors is limited to the study of mosquito immune responses. However, the complex life cycle of Plasmodium within the vector suggests that non-immune physiological and metabolic pathways may pla
The particle-rotor model using strong coupling basis functions is briefly reviewed. Recent developments are discussed. For example, a formalism for odd-odd nuclei (and negative parity states in even nuclei) is presented. With a standard neutron-proton interaction, measured spins and moments of transitional and deformed Ho nuclei are used to extract their main configurations. Total energy calculati
A surge in societal and scientific discussion surrounds psychedelic research. One surprising fact keeps standing out: Many users report the psychedelic experience as a positive and lasting impact on their quality of life. The present study aimed to explore the quality and consequences of the most impacting psychedelic experience, with the user's Big Five personality in focus. This experienced samp
Yogurt is an ancient food, used for a better preservation of milk. Milk gets fermented by Streptococcus thermophilicus and Lactobacillus bulgaricus (lactic acid bacteria, LAB) which converts the lactose present in the milk to lactic acid. These probiotics support the microbial population balance of the gastrointestinal tract. Sweet potato, Ipomoea batatas, is an important security crop in developi
The human right violations in Kurdish cities in 90s is the focus point of the Kurdish documentary cinema. Although there are several documentary studies on trauma, little attention has been given to experiences of audiences. The aim of this study is to explore the ways in which the audience engages with the documentary in the context of The Well (Bîr, dir. Veysi Altay, 2018), which is one of the i
Gender roles and constructions of ideals have long imposed unrealistic expectations on people to behave in certain ways and even be certain types of people. Women, more so, than others. Ideals of womanhood, what it means to be a woman, a good woman, a new woman, have required women to perform who they are at all times. The imaginary of the “New Woman” is only of these ideals that has been around g
The last two decades have been marked by pandemics, epidemics and outbreaks of infectious diseases. They have highlighted the challenges and flaws the EU has been standing in front of regarding public health emergency preparedness. Public health officials and scholars have presented the need for more developed coordination, cohesion and communication between the Member States and the EU and its in
Natural events that happen more rarely have historically been more difficult to study and continue to require different methods. For example, rare occurrences of natural disasters and weather events can have return periods of thousands of years but because of their large impact are very important to study. In addition to being used to study the changing climate, climate models have the advantage o
A study on the online process of producing idioms in writing and how second language learners manage the production and comprehension of idioms may provide a useful and comprehensive investigation of the production, comprehension and acquisition of language. The study in this paper investigated how Swedish (L1) second language learners of English (L2) produce and comprehend written idioms in the L
