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Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β-amyloid peptides (Aβ), while NFTs contain hyperphosphorylated tau proteins. Patients with familial AD who have mutations in the amyloid precursor protein (APP) gene have either increased production of Aβ or generate more aggregation-pron
Dietary sphingomyelin (SM) undergoes sequential cleavage to ceramide and sphingosine in the intestine. A distinctive intestinal sphingomyelinase (SMase) with alkaline pH-optimum was earlier identified by us. The activity was highest in middle and lower small intestine, but its role in SM digestion has not been clarified. In this study we examined the extension and capacity of SM digestion in vivo.
This article focuses on one of the most ground-breaking technological attempts to create a novel immersive media environment for a heightened televisual user experience: 3DTV, a Network of Excellence project that was funded by the European Commission 6th Framework Information Society Technologies Programme. Based on the theoretical framework mainly outlined in the works of Jonathan Crary and Brian
This paper aims to discuss subalterns in different social environments in Sweden. The potential of archaeological studies of landless subalterns in rural and urban areas are shown though a number of case studies. It is argued that archaeology can show the multivocality of the lives of the subalterns, in the same way as it shows how the subalterns organized their daily life. This is done through th
A ca 20 m thick succession of upper Furongian (Cambrian Stage 10) through Middle Ordovician (Darriwilian) strata exposed at Lanna, in the province of Närke, south-central Sweden, is described. The upper Furongian is represented by the Alum Shale Formation and reflects an overall shallowing trend that ultimately resulted in emergence above sea level and subaerial conditions. Hence, as in most other
Death and severe morbidity attributable to anesthesia are commonly associated with failed difficult airway management. When an airway emergency develops, immediate access to difficult airway equipment is critical for implementation of rescue strategies. Previously, national expert consensus guidelines have provided only limited guidance for the design and setup of a difficult airway trolley. The o
Top marginal rates in income taxes increased significantly during the two World Wars in most Western countries, which points towards increases in their progressivity. We argue, however, that this war-related effect is less clear-cut than previously thought: wartime inflation could have exerted a counteracting impact by pushing citizens into higher tax brackets, including new individuals from the b
Background: Calcitonin gene-related peptide and its receptor, consisting of receptor activity-modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest because of the role they play in migraine and recently developed migraine therapies. Methods: To better understand the function of this neuropeptide, we used immunohistochemistry to determine a detailed distribution of
In late summer-early autumn, trees undergo growth cessation culminating in bud set. For a wide range of plants, including Populus, photoperiod is considered as the primary environmental cue determining timing of growth cessation and shoot to bud transition. However, studies on Populus have revealed temperature influence on seasonal growth cessation and bud set. In this study we examine the role of
Glacial-interglacial variations in CO 2 and methane in polar ice cores have been attributed, in part, to changes in global wetland extent, but the wetland distribution before the Last Glacial Maximum (LGM, 21 ka to 18 ka) remai
Billions of animals migrate between breeding and non-breeding areas worldwide. Partial migration, where both migrants and residents coexist within a population, occurs in most animal taxa, including fish, insects, birds and mammals. Partial migration has been hypothesised to be the most common form of migration and to be an evolutionary precursor to full migration. Despite extensive theoretical mo
We use a laboratory experiment to investigate a novel reason for the lack of empirical support for the Hotelling rule for nonrenewable resources. Specifically, we test whether producers with large resource stocks focus less on the dynamic component of their extraction decision, making them shift extraction to the present and focus more on strategic behavior. Exploiting exogenous variation in stock
Two new lithiated phases of V6O13 were formed by carefully tuning the temperature of electrochemical lithiation in a 'coffee-bag' type Li-ion battery at 2.78 V versus Li/Li+. These were studied by single-crystal X-ray diffraction. A phase with the composition Li2/3V6O13 was obtained at 308 K with a unit cell three times the volume of the original V6O13 cell. A single crystal discharged at ambient
Background: Music festivals are known to attract a high proportion of drug users. Methods: Using a survey of 1,772 visitors at the Roskilde Festival in Denmark, we assessed substance use at the festival, the incidence of use of substances among never-users and the incidence of use among lifetime users who had not used a substance in the past 12 months. Results: New onset of tobacco use was reporte
Henzinger et al. posed the so called Online Boolean Matrix-vector Multiplication (OMv) conjecture and showed that it implies tight hardness results for several basic partially dynamic or dynamic problems [STOC’15].We show that the OMv conjecture is implied by a simple off-line conjecture. If a not uniform (i.e., it might be different for different matrices) polynomial-time preprocessing of the mat
Attempts to measure the capitalization of local taxes into property prices, starting with Oates (1969), have suffered from a lack of local public service controls. We revisit this vast literature with a novel dataset of 947 time-varying local characteristic and public service controls for all municipalities in Sweden over the 2010-2016 period. To make use of the high dimensional vector of control
