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The diagnostic utility of DNA copy number analysis of core needle biopsies from soft tissue and bone tumors

Morphologic and immunohistochemical analysis of preoperative core needle biopsies (CNB) is important in the management of patients with soft tissue and bone tumors (STBTs). Most SBTB subtypes have more or less extensive DNA copy number aberrations (CNA), potentially providing useful diagnostic information. To evaluate the technical feasibility of single nucleotide polymorphism (SNP) array analysis

Osteosarcomas With Few Chromosomal Alterations or Adult Onset Are Genetically Heterogeneous

Osteosarcoma is the most common primary bone malignancy, often detected in children and adolescents and commonly associated with TP53 alterations along with a high number of chromosomal rearrangements. However, osteosarcoma can affect patients of any age, and some tumors display less genetic complexity. Besides TP53 variants, data on key driving mutations are lacking for many osteosarcomas, partic

Transformative Screenwriting: Charlie Kaufman’s Postmodern Adaptation of Story

The essay's investigation of postmodern storytelling and transformative screenwriting, in relation to how Robert McKee's Story is reflected in Charlie Kaufman's Adaptation – in text and subtext, form and content – shows that the film's form is that of the classical archplot. It is only Adaptation's content, reflecting the dream of an art film/antiplot that is critical – while t

'Sins of the Past' - Protection of Fundamental Rights in Individual Sanctions in the Historical, Institutional, and Judicial CFSP Context

Sedan den 24 februari 2022 har Europeiska unionen stått inför ett konventionellt krig på sin tröskel och en ökad geopolitisk spänning från öst. Detta har krävt av Rådet att agera snabbt och kraftfullt inom ramen för sin kompetens för den gemensamma utrikes- och säkerhetspolitiken. För att motverka Rysslands aggression har rådet utfärdat omfattande sanktionspaket som aldrig tidigare har använts i sSince 24 February 2022, the European Union has faced a conventional war on its doorstep and an increase in geopolitical tension with the East. This has required the Council to act quickly and forcefully within its competence in the area of Common Foreign and Security Policy. To counteract the adverse geopolitical actions the Council has issued sanctions packages which have never been utilized befo

Blockchain v. Personal Data — A Rising Conflict Between Technology and the Law?

Denna uppsats undersöker blockkedjeteknologin utifrån dataskyddsförordningen (GDPR). Fokusområdet är skydd av personuppgifter på blockkedjor. Blockkedjeteknologin kan sammanfattas som en delad, distribuerad liggare där information endast kan läggas till, inte tas bort. Tekniken är ett sätt att skapa tillit, och har i förlängningen potentialen att ta bort behovet av mellanhänder. Från ett juridiskThis thesis examines the blockchain technology from a General Data Protection Regulation (GDPR) point of view. The focus area is the protection of personal data in blockchains. Blockchain can be summarized as a shared, decentralized ledger where data can only be added, not removed. In essence, it works like a trust-creator that has the potential to remove the need for middlemen. From a legal pers

Characteristics of Androgen Deficiency in Late-Onset Hypogonadism: Results from the European Male Aging Study (EMAS).

Context:Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T). Objective:The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria. Design, Setting, and Participants:The des

The release of a pheromonotropic neuropeptide, PBAN, in the turnip moth Agrotis segetum, exhibits a circadian rhythm

In the female turnip moth, Agrotis segetum, a pheromone biosynthesis activating neuropeptide (PBAN) stimulates sex pheromone biosynthesis which exhibits a daily rhythm. Here we show data supporting a circadian rhythm in PBAN release from the corpora cardiaca, which we propose regulates the endogenous rhythm in sex pheromone biosynthesis. This conclusion is drawn as the observed daily rhythm in PBA

Clinical and Molecular Characteristics of Squamous Cell Carcinomas From Fanconi Anemia Patients

Fanconi anemia is a recessively inherited disease that is characterized by congenital abnormalities, bone marrow failure, and a predisposition to develop cancer, particularly squamous cell carcinomas (SCCs) in the head and neck and anogenital regions. Previous studies of Fanconi anemia SCCs, mainly from US patients, revealed the presence of high-risk human papillomavirus (HPV) DNA in 21 (84%) of 2

Time-lagged genomic erosion and future environmental risks in a bird on the brink of extinction

Global biodiversity is rapidly declining due to habitat degradation and genomic erosion, highlighting the urgent need to monitor endangered species and their genetic health. Temporal genomics and ecological modelling offer finer resolution than single-Time-point measurements, providing a comprehensive view of species' recent and future trajectories. We investigated genomic erosion and environmenta

Establishing the Cross-Cultural Validity of the Immune Status Questionnaire Using Rasch Analysis

Reliable assessment of self-reported immune function is essential for identifying at-risk populations, monitoring public health interventions and informing global health strategies. Yet, current instruments are imprecise and lack cross-cultural validity. This study aimed to assess the cross-cultural validity of the 7-item Immune Status Questionnaire (ISQ). The Partial Credit Rasch model was applie

Growth and Business Cycles -Swedish Manufacturing Industry 1952-2001

Popular Abstract in Swedish Denna studie betonar att de mekanismer, som skapar tillväxt, inte nödvändigtvis är universella utan kan skilja sig åt mellan olika områden, beroende på vad som produceras och vilken teknik som används. Avhandlingen hävdar inledningsvis att ekonomisk tillväxt är den viktigaste enskilda faktor som påverkar individers inkomstnivå och att ökad produktivitet i sin tur är gruThis study shows that the mechanisms behind knowledge accumulation and the sources of productivity growth differ from industry to industry depending on what is produced and what technology is used. Although it is apparent to most researchers in the field that the only way to explain long-run growth in output per capita is through technological progress and accumulation of knowledge that counteract

Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice

The mucosal lymphocyte integrin alpha E(CD103)beta 7 is thought to be important for intraepithelial lymphocyte (IEL) localization or function. We cloned the murine integrin gene encoding alpha E, localized it to chromosome 11, and generated integrin alpha E-deficient mice. In alpha E-/- mice, intestinal and vaginal IEL numbers were reduced, consistent with the known binding of alpha E beta 7 to E-

Performance of an alpha-IPEM

The ion photon emission microscope, or IPEM, is the first device that allows scientists to microscopically study the effects of single ions in air on semiconductors, microchips and even biological cells without having to focus the beam. Reported here is a prototype, the size of a conventional optical microscope, developed at Sandia. The alpha-IPEM, that employs alpha particles from a radioactive s

Civilingenjörsutbildning i risk, säkerhet och krishantering utbildningsplan

Civilingenjörsutbildning i risk, säkerhet och krishantering utbildningsplan Sida 1 av 7 Utbildningsplan Civilingenjörsutbildning i risk, säkerhet och krishantering Master of Science in Engineering, Risk, Safety and Crisis Management - Fakultet: Lunds tekniska högskola, LTH - Programkod: TARSK - Omfattning: 300 högskolepoäng - Tillträdesnivå: Grundnivå - Examensnivå: Avancerad nivå - Beslutsfattare

https://www.student.lth.se/fileadmin/lth/student/Utbildningsplaner_2023_och_fram/Grund_svenska/26_27/Utbildningsplan_Civilingenjoersutbildning_i_risk__saekerhet_och_krishantering_26-27.pdf - 2026-05-04

Microsoft Word - AU_ 200302_FU Uppföljning kvalitetsdialoger 2019 .docx

Microsoft Word - AU_ 200302_FU Uppföljning kvalitetsdialoger 2019 .docx Postadress Box 192, 22100 Lund Besöksadress LUX (Hus B), Helgonavägen 3, 22100 Lund Telefon 046-222 77 35 Webbadress http://www.ht.lu.se/person/HegeIreneMarkussen Samuel Byrskog, prodekan Hege Markussen, utbi ldningsledare Uppföljning kvalitetsdialoger för forskarutbildning 2019 Detta dokument utgör HT-fakulteternas gemensamma

https://www.ht.lu.se/fileadmin/user_upload/ht/dokument/Fakulteterna/Kvalitetsarbete/Uppfoeljning_kvalitetsdialoger_2019_forskarutbildningen.pdf - 2026-05-04