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We have made a study by isothermal calorimetry of the heat production response of root and tuber tissue to wounding. Samples with different surface to volume ratios were prepared from carrots, potatoes and swedes (rutabaga) and the overall metabolic heat was measured in closed glass ampoules in a TAM Air isothermal calorimeter. The evaluation was made by assuming that a certain heat production rat

Cytokines play a major role in lymphoid development. Defects of the common gamma chain (gamma (c)) or of the JAK3 protein in humans have been shown to result in a severe combined immune deficiency (SCID), with a profound defect in T and natural killer (NK)-cell development, whereas B-cell generation is apparently unaffected (T-B+NK- SCID). While extensive molecular and biochemical analysis of thes

Popular Abstract in Swedish Att vara äldre, beroende av hjälp och leva med varaktig smärta. För äldre människor som är beroende av hjälp från omvärlden för att klara av sitt dagliga liv, utgör inte bara den nedsatta funktion ett problem. Många är drabbade även av andra problem, varav ett vanligt är ihållande och varaktig smärta. För vissa äldre med gravt nedsatt funktion kan språket ha drabbat's This thesis explores everyday living with persistent pain from the perspectives of functionally dependent older persons in pain and of staff. A combination of qualitative and quantitative methods was chosen. Data were collected using interviews and tools for assessing pain. The first data collection included 66 persons (65+) living in sheltered accommodation and their corresponding contact nurses.

Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have

Background Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive heart rate increase on standing and orthostatic intolerance. Previous data indicate autoimmune involvement. We studied serum activity against G protein-coupled receptors in relation to symptoms in patients with POTS and controls using a commercial cell-based assay. Methods and Results Forty-eight patients wit

Introduction: as South Africa's maternal mortality ratio increased between 1990 and 2015, the country failed to reach the United Nations millennium development goal 5a. The maternal mortality ratio of Limpopo province is higher than the national average and previous studies report shortages of manpower and medical equipment in Limpopo province. The overall study aim was to elucidate views and expe

Tumor-associated macrophages (TAMs) continuously fine tune their immune modulatory properties, but how gene expression programs coordinate this immune cell plasticity is largely unknown. Selective mRNA translation, controlled by MNK1/MNK2 and mTOR pathways impinging on eIF4E, facilitates reshaping of proteomes without changes in abundance of corresponding mRNAs. Using polysome profiling developed

Background: Infectious complications in ANCA associated vasculitis (AAV) are a major cause of morbidity and mortality. The aim of this study was to determine the incidence rates, predictors and outcome of severe infections in AAV. Methods: We conducted a population-based cohort study in Southern Sweden with 326 incident cases of AAV diagnosed between 1997 and 2016. Diagnosis of vasculitis was conf

För att mildra förlusten av biologisk mångfald i jordbruksmarker, inklusive dess pollinatörer, har många ansträngningar ägnats åt att bevara naturbetesmarker och slåtterängar. Dock är redan förlorade naturbetesmarker och slåtterängar svåra att återställa och kostsamma att hantera för ökade fördelar för biologisk mångfald. Dessutom är idag många marker som tidigare användes till slåtterängar nu betTo mitigate loss of farmland biodiversity, including insect pollinators, much effort has been spent on preserving semi-natural grasslands. However, already lost grasslands are difficult to restore and costly to manage for increased benefits to biodiversity. Previously often mowed semi-natural grasslands are today mostly managed by grazing, resulting in a lack of critical floral resources for many

Background The impact of baseline anemia in a contemporary acute coronary syndrome (ACS) population undergoing percutaneous coronary intervention in the era of predominant radial artery access, potent P2Y12 inhibition, and rare use of glycoprotein IIb/IIIa inhibitors has not been adequately studied. Methods and Results ACS patients who underwent percutaneous coronary intervention between 2014 and

Parasites are expected to exert long-term costs on host fecundity and longevity. Understanding the consequences of heritable polymorphic variation in disease defence in wild populations is essential in order to predict evolutionary responses to changes in disease risk. Telomeres have been found to shorten faster in malaria-diseased individuals compared with healthy ones with negative effects on lo

Purpose of this paper The purpose of this article is to explore themes and challenges in making logistics environmentally sustainable with a complexity theoretical perspective. Design/methodology/approach The research is explorative and based on a cross-sectional design focusing on different entities of supply chains. The study set out with a systematic review and content analysis of articles in

Objectives The purpose of this study was to validate existing 12-lead electrocardiographic (ECG) ST-segment elevation myocardial infarction (STEMI) criteria in the diagnosis of acute myocardial infarction (AMI) and the application of similar ST-segment depression (STEM I-equivalent) criteria with contrast-enhanced cardiac magnetic resonance imaging (ceMRI) as the diagnostic gold standard. Backgrou

To study which individual characteristics and environmental factors correlate with fear of moving outdoors and whether fear of moving outdoors predicts development of mobility limitation. Observational prospective cohort study and cross-sectional analyses. Community and research center. Seven hundred twenty-seven community-living people aged 75 to 81 were interviewed at baseline, of whom 314 took

Combretastatin A-4 disodiumphosphate (CA4P), a prodrug formulation of the natural product combretastatin A-4 (CA4), is currently in clinical investigation for the treatment of cancer. In vivo, CA4P is rapidly enzymatically converted to CA4, a potent inhibitor of tubulin polymerization (IC50 = 1-2 muM), and rapidly causes bloodflow shutdown in tumor tissues. A variety of alkyl and aryl di- and trie