Search results

Erythrocyte-binding antigens (EBAs) and P. falciparum reticulocyte-binding homologue proteins (PfRhs) are two important protein families that can vary in expression and utilization by P. falciparum to evade inhibitory antibodies. We evaluated antibodies at repeated time-points among individuals living in an endemic region in Nigeria over almost one year against these vaccine candidates. Antibody l

This paper introduces a number of advancements of our recently proposed model of atrioventricular (AV) node function during atrial fibrillation (AF). The model is defined by parameters characterizing the arrival rate of atrial impulses, the probability of an impulse choosing either one of the two AV nodal pathways, the refractory periods of these pathways, and their prolongation. In the updated mo

Myeloid cells play a central role in atherosclerosis. We investigated the associations between the plasma levels of growth factors and chemokines that regulate myeloid cell homeostasis and function and the risk of first-time acute coronary events in middle-aged persons. Methods and Results-We measured baseline plasma levels of macrophage colony-stimulating factor monocyte chemotactic protein 1; C-

The host response to immunologically incompatible intrastriatal neural grafts was studied using immunohistochemical techniques. Dissociated ventral mesencephalic tissue from embryonic donors of either syngeneic, allogeneic or xenogeneic (mouse) origin was stereotaxically implanted into adult rats. The brains were analysed 4 days, 2 weeks or 6 weeks after grafting with antibodies against the follow

Respiratory tract infections are one of the leading causes of mortality worldwide urging better understanding of interactions between pathogens causing these infections and the host. Here we report that an extracellular matrix component proline/arginine-rich end leucine-rich repeat protein (PRELP) is a novel antibacterial component of innate immunity.We detected the presence of PRELP in human bron

Organometal halide perovskites in the form of nanocrystals (NCs) have attracted enormous attention due to their unique optoelectronic and photoluminescence (PL) properties. Here, we examine the phase composition and the temperature dependence of emission line width broadening in formamidinium lead bromide (FAPbBr3) perovskite nanocrystals (NCs) for light-emitting applications and identify differen

This guideline aims to describe the complement system and the functions of the constituent pathways, with particular focus on primary immunodeficiencies (PIDs) and their diagnosis and management. The complement system is a crucial part of the innate immune system, with multiple membrane-bound and soluble components. There are three distinct enzymatic cascade pathways within the complement system,

Observations find a median star formation efficiency per free-fall time in Milky Way Giant Molecular Clouds (GMCs) of the order of ϵff∼1 per cent with dispersions of ∼0.5dex⁠. The origin of this scatter in ϵff is still debated and difficult to reproduce with analytical models. We track the formation, evolution and destruction of GMCs in a hydrodynamical simulation of a Milky Way-like galaxy and by

alpha 1-Microglobulin is an immunosuppressive plasma protein synthesized by the liver. The isolated protein is yellow-brown, but the hypothetical chromophore has not yet been identified. In this work, it is shown that a human liver cell line, HepG2, grown in a completely synthetic and serum-free medium, secretes alpha 1-microglobulin which is also yellow-brown, suggesting a de novo synthesis of th

OBJECTIVE: Because elevated copeptin, a marker of vasopressin, is linked to low water intake and high diabetes risk, we tested the effect of water supplementation on copeptin and fasting glucose.DESIGN, SETTING, AND PARTICIPANTS: Thirty-one healthy adults with high copeptin (>10.7 pmol · L-1 in men and >6.1 pmol·L-1 in women) identified in a population-based survey from 2013 to 2015 and with a cur

The evolution of social media has introduced novel possibilities for work and interaction in organizations. The wiki technology is one important kind of social media technologies that is increasingly used to facilitate the creation and sharing of organizational knowledge within communities. Given the increasing use of social media in organizations and the lack of knowledge on their consequences fo

There is a lack of clinical protocols for re-irradiation in paediatric central nervous system (CNS) tumours. To fill this void, the Swedish Workgroup of Paediatric Radiotherapy (SBRTG) compiled national guidelines on re-irradiation in paediatric CNS tumours (diffuse intrinsic pontine glioma, ependymoma, germinoma and medulloblastoma). These have been in clinical practice since 2019 in all paediatr

We examine the use of in-cylinder measurements for engine control, with emphasis on emissions control during cold start. First, the cold start emissions control problem is described. An overview of previous research in the area of in-cylinder measurements for control is presented, including sensors for pressure and other quantities. Next, analysis of cylinder pressure is described. Lastly, a cold-

The ESS linac will deliver an unprecedented 5 MW of average beam power when completed. Beyond the 90 MeV normal conducting front-end, the acceleration is performed using superconducting structures up to the design energy of 2 GeV. As the ESS will send the beam to a fixed tungsten target, the emittance is not as important a factor as in injectors. However, the losses have to be studied in detail, i

The ESS linac is currently under construction in Lund, Sweden, and once completed it will deliver an unprecedented 5 MW of average power. The ion source and LEBT commissioning starts in 2018 and will continue with the RFQ, MEBT and the frst DTL tank next year and up to the end of the fourth DTL tank in 2020. This paper will summarize the commissioning plans for the normal conducting linac with foc