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Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases with inflammation affecting small blood vessels and includes granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). In this study, we investigated granulocyte and monocyte subsets in a large cohort of AAV patients with emphasis on disease activity and tendency to relapse. A

AIM: To investigate the changes in prevalence and incidence of pharmacologically and non-pharmacologically treated diabetes in Sweden during 2005 to 2013.METHODS: We obtained data on gender, date of birth and pharmacologically and non-pharmacologically treated diabetes from national registers for all Swedish residents.RESULTS: During the study period a total of 240 871 new cases of pharmacological

Background: Gene expression (GEX) signatures in breast cancer provide prognostic information, but little is known about their predictive value for tamoxifen treatment. We examined the tamoxifen-predictive value and prognostic effects of different GEX signatures in premenopausal women with early breast cancer. Methods: RNA from formalin-fixed paraffin-embedded tumor tissue from premenopausal women

Objective: Knee osteoarthritis (OA) is associated with meniscal degeneration that may involve disorganization of the meniscal collagen fiber network. Our aims were to quantitatively analyze the microstructural organization of human meniscus samples in 3D using micro-computed tomography (μCT), and to compare the local microstructural organization between OA and donor samples. Method: We collected p

Background and aims: Gut transit time is a key modulator of host-microbiome interactions, yet this is often overlooked, partly because reliable methods are typically expensive or burdensome. The aim of this single-arm, single-blinded intervention study is to assess (1) the relationship between gut transit time and the human gut microbiome, and (2) the utility of the a € blue dye' method as an inex

The integration of daylight and electric lighting, considering user satisfaction and energy savings potentially can contribute significantly to reduce energy demand for lighting, that represents 18% of global energy demands. This paper presents the work and first results of IEA SHC Task 61/EBC Annex 77 “Integrated Solutions for Daylighting and Electric Lighting: From component to user centered sys

BACKGROUND: Perfluoroalkyl substances (PFAS) have been associated with impaired antibody levels after childhood vaccinations and immunosuppressive effects in animals. However, the in vivo effects of PFAS on antigen specific human T cell responses have not been investigated in adults. In Ronneby, Sweden, the drinking water of one of the water works was previously highly contaminated with primarily

A study of optical and transport properties of semiconductor quantum well structures subjected to nanoimprint lithography (NIL), with its pressure and temperature cycles, has been undertaken to ascertain if this lithography technique induces detrimental changes in these properties of the active layers over a range of pressures and temperatures, typically used in this printing process. Ga0.47In0.53

This paper presents a joint large eddy simulation and laser diagnostic investigation of premixed turbulent low swirl flames. A lean premixed methane/air mixture, of the equivalence ratio 0.60-0.66, is injected from a 50 mm diameter low swirl burner to a low speed co-flowing air at room temperature and pressure. The level-set G-equation is employed to simulate the inner layer flame front. Flamelet

Rheumatoid arthritis (RA) is a chronic autoimmune disease with a largely unknown aetiology. The risk of developing RA is partly dependent on genetic factors, which has motivated extensive efforts to identify the disease regulating genes as away to understand disease pathogenesis. However, identifying genes controlling complex diseases such as RA has proven extremely difficult and to date only a fe

delta C-13 values of numerous limestone samples from Katian (Upper Ordovician) successions in Oklahoma and the Upper Mississippi Valley document the presence of at least three of the four positive excursions that have been recognized in the lower-middle Katian interval in the Cincinnati region in Ohio. Kentucky, and Indiana. A comparison with Estonia reveals that five out of the six positive excur

Mucosal tissues contain large numbers of memory CD4(+) T cells that, through T-cell receptor-dependent interactions with antigen-presenting cells, are believed to have a key role in barrier defense and maintenance of tissue integrity. Here we identify a major subset of memory CD4(+) T cells at barrier surfaces that coexpress interleukin-18 receptor alpha (IL-18Rα) and death receptor-3 (DR3), and d

Many popular direction-of-arrival (DOA) estimators rely on the fact that the array response vector of the array is Vandermonde, for example, that of a uniform linear array (ULA). Array interpolation is a preprocessing technique to transform the array response vector of a planar array of arbitrary geometry to that of a ULA over an angular sector. While good approximation within the target sector is

Popular Abstract in Swedish Föreliggande avhandling, I litteraturens mittfåra, behandlar bokmarknad, bokklubbar och litteraturen under 1970-talet i Sverige. Bakgrunden till undersökningen är de radikala förändringar som skedde på den svensk bokmarknaden efter den genomgripande avregleringen av handeln med böcker 1970. Bokklubbarna växte från att inneha en marknadsandel på 9% 1970 till att ha 30% aThe present dissertation, I litteraturens mittfåra, deals with book trade, book clubs, and the fiction prose of the 1970s in Sweden. The background to the study is the radical change in Swedish book trade through a far-reaching deregulation of the trade in 1970. The book clubs expanded from a position where they held a 9% share of the market in 1970 to a market share of 30% in 1980.And the specifi

This paper focuses on the performance analysis of general charge sampling circuits that have been applied in signal capture. The theoretical analysis applies not only for small signal capture, but also for normal signal sampling. Based on a general charge sampling model, the transferring function, together with noise transference, clock jitter tolerance, and clock feedthrough effects, are analysed

Aims Baseline adiponectin concentrations predict incident Type 2 diabetes mellitus in the Diabetes Prevention Program. We tested the hypothesis that common variants in the genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1, ADIPOR2) would associate with circulating adiponectin concentrations and/or with diabetes incidence in the Diabetes Prevention Program population. Methods Seventy-s

Treatment with IgG against the malondialdehyde (MDA)-modified apolipoprotein B-100 epitope p45 reduces atherosclerosis in experimental models. This study investigated the association between p45 IgG autoantibodies and plaque inflammation in subjects with advanced cardiovascular disease.