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Tumor-associated macrophages (TAMs) are attractive targets for immunotherapy. Recently, studies in animal models showed that treatment with an anti-TAM antibody directed against the scavenger receptor MARCO resulted in suppression of tumor growth and metastatic dissemination. Here we investigated the expression of MARCO in relation to other macrophage markers and immune pathways in a non-small cel

Context: The previously reported absence of 65-kDa glutamate decarboxylase antibody (GAD65Ab)-specific antiidiotypic antibodies (anti-Id) in type 1 diabetes (T1D) patients at clinical onset could be due to an inability to mount an antibody response to GAD65Ab or a longitudinal decline in anti-Id levels. Objective and Design: We investigated anti-Id levels in longitudinal samples obtained from T1D

HIP 9618 (HD 12572, TOI-1471, TIC 306263608) is a bright (G = 9.0 mag) solar analogue. TESS photometry revealed the star to have two candidate planets with radii of 3.9 ± 0.044 R (HIP 9618 b) and 3.343 ± 0.039 R (HIP 9618 c). While the 20.77291 d period of HIP 9618 b was measured unambiguously, HIP 9618 c showed only two transits separated by a 680-d gap in the time series, leaving many possibilit

In order to assess the potential of electrical resistivity for imaging gas migration at landfills, two relatively well-known sites - one bioreactor landfill and a conventional landfill - have been monitored successively. A three-dimensional resistivity image could be constructed every two hour on both sites. Meteorological parameters were monitored at the same time, with one measurement taken ever

During the last years, numerous research projects focussed on re-examination of past excavations, giving birth to re-evaluation of their documentation and material or to new discoveries. The aim of this paper is to present an ongoing research on the digital re-assessment of the Ayia Irini sanctuary’s stratigraphy using 3D GIS, by corroborating published material with data extracted from the origin

Text visualization techniques often make use of automatic text classification methods. One of such methods is stance analysis, which is concerned with detecting various aspects of the writer's attitude towards utterances expressed in the text. Existing text visualization approaches for stance classification results are usually adapted to textual data consisting of individual utterances or short me

Non-typeable Haemophilus influenzae (NTHi) is a Gram-negative human commensal commonly residing in the nasopharynx of preschool children. It occasionally causes upper respiratory tract infection such as acute otitis media, but can also spread to the lower respiratory tract causing bronchitis and pneumonia. There is increasing recognition that NTHi has an important role in chronic lower respiratory

This paper addresses the quantification of the value of damage detection system and algorithm information on the basis of Value of Information (VoI) analysis to enhance the benefit of damage detection information by providing the basis for its optimization before it is performed and implemented. The approach of the quantification the value of damage detection information builds upon the Bayesian d

Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10−15) and replication (adjusted OR = 2.93, P = 2

The master regulator of neuroendocrine differentiation, achaete-scute complex homolog 1 (ASCL1) defines a subgroup of lung adenocarcinoma. However, the mechanistic role of ASCL1 in lung tumorigenesis and its relation to the immune microenvironment is principally unknown. Here, the immune landscape of ASCL1-positive lung adenocarcinomas was characterized by immunohistochemistry. Furthermore, ASCL1

BACKGROUND: The incidence of cutaneous malignant melanoma (CMM) and melanoma in situ (MIS) has been increasing during the last 50 years. Malignant melanoma (MM) is also the most common intraocular malignancy (IMM). Besides ultraviolet radiation, the cause of these tumours is largely unknown.OBJECTIVES: We designed a study to examine the effect of body mass index (BMI) and tobacco use on the risk f

Gene editing technologies, such as CRISPR/Cas9, hold great promises for the advancement of science and technology. These foundational technologies enable to modify the genetic structure of living organisms with unprecedented precision. Potential applications include both plant, animal and human genetic interventions. In plant biology, gene editing introduces more precise, target- and time-efficien

This project was recently carried out as a part of The Swedish Pompeii Project, which was started in 2000 as a research and fieldwork activity initiated by the Swedish Institute in Rome. The aim was to record and analyze an entire Pompeian city block, Insula V 1. Since autumn 2011 a new branch of advanced digital archaeology, involving 3D reconstructions and documentation methods, was added to the

In this paper water and salt mass balances for the Dead Sea were modeled. Precipitation, evaporation, river discharges, ground water flows, input/output from potash companies and salt production, and brine discharge were included in the models. The mixing time in the Dead Sea was modeled using a single-layer (well-mixed) a two-layer (stratified) system. Using the single-layer approach the water le

This work deals with the problem of direction of arrival estimation of interferometric synthetic aperture radar (InSAR) signals in presence of layover. The focus here is on realistic acquisition systems with a low number of phase centres and nonuniform array geometry. An interpolated array approach is proposed, in order to apply spectral estimation techniques designed for uniform linear arrays. In

In many organizations it is considered of vital importance to translate its vision and strategy into objectives, to determine the best means of achieving these and to review the results – with participation from all members, from management to shop floor. The objective of this study was to make a first test of a method that could be applied for verbalizing and communicating a common vision and ide

In Nordic countries, demand response (DR) programs are critical for enhancing energy flexibility and reducing peak electricity consumption in buildings and industry. Accurate short-term demand forecasting is essential to support these programs, especially in the context of cities with varying levels of data availability. This paper compares three different forecasting approaches for hourly electri

Direct reprogramming of somatic cells into induced neurons (iNs) has become an attractive strategy for the generation of patient-specific neurons for disease modeling and regenerative neuroscience. To this end, adult human dermal fibroblasts (hDFs) present one of the most relevant cell sources. However, iNs generated from adult hDFs using two-dimensional cultures are difficult to maintain in vitro