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Attachment goes to court: child protection and custody issues

Attachment theory and research are drawn upon in many applied settings, including family courts, but misunderstandings are widespread and sometimes result in misapplications. The aim of this consensus statement is, therefore, to enhance understanding, counter misinformation, and steer family-court utilisation of attachment theory in a supportive, evidence-based direction, especially with regard to

Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons

Microglia are activated in many neurological diseases and have been suggested to play an important role in the development of affective disorders including major depression. To investigate how microglial signaling regulates mood, we used bidirectional chemogenetic manipulations of microglial activity in mice. Activation of microglia in the dorsal striatum induced local cytokine expression and a ne

Nontypeable haemophilus influenzae P5 binds human C4b-binding protein, promoting serum resistance

Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative human pathogen that causes infections mainly in the upper and lower respiratory tract. The bacterium is associated with bronchitis and exacerbations in patients suffering from chronic obstructive pulmonary disease and frequently causes acute otitis media in preschool children. We have previously demonstrated that the binding of C4b bindi

Cell-Free DNA Promotes Thrombin Autolysis and Generation of Thrombin-Derived C-Terminal Fragments

Cell-free DNA (cfDNA) is the major structural component of neutrophil extracellular traps (NETs), an innate immune response to infection. Antimicrobial proteins and peptides bound to cfDNA play a critical role in the bactericidal property of NETs. Recent studies have shown that NETs have procoagulant activity, wherein cfDNA triggers thrombin generation through activation of the intrinsic pathway o

Chemokines modulate glycan binding and the immunoregulatory activity of galectins

Galectins are versatile glycan-binding proteins involved in immunomodulation. Evidence suggests that galectins can control the immunoregulatory function of cytokines and chemokines through direct binding. Here, we report on an inverse mechanism in which chemokines control the immunomodulatory functions of galectins. We show the existence of several specific galectin-chemokine binding pairs, includ

Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here, we test whether the integrin, when engaged to an extracellular ligand and the cytoskeleton, adopts a specific orientation dictated by the direction of actin flow on the surface of migrating cells. We insert GFP into the rigid, ligand-binding head of the integrin, model with

Purification of antibodies using protein L-binding framework structures in the light chain variable domain

Protein L from the bacterial species Peptostreptococcus magnus binds specifically to the variable domain of Ig light chains, without interfering with the antigen-binding site. In this work a genetically engineered fragment of protein L, including four of the repeated Ig-binding repeat units, was employed for the purification of Ig from various sources. Thus, IgG, IgM, and IgA were purified from hu

Interaction of Laponite with Membrane Components - Consequences for Bacterial Aggregation and Infection Confinement

The antimicrobial effects of Laponite nanoparticles with or without loading of the antimicrobial peptide LL-37 was investigated along with their membrane interactions. The study combines data from ellipsometry, circular dichroism, fluorescence spectroscopy, particle size/ζ potential measurements, and confocal microscopy. As a result of the net negative charge of Laponite, loading of net positively

Long-acting nitrate use before and after revascularization to evaluate angina in chronic coronary syndrome : a case-crossover study from SCAAR

BACKGROUND: The ORBITA and ORBITA-2 trials have provided valuable insights into the effects of coronary revascularization in chronic coronary syndrome (CCS). However, uncertainties remain regarding the efficacy of revascularization on symptoms in large real-world populations. To evaluate the efficacy of revascularization, we used dispensed long-acting nitrates as a proxy for the presence of angina

A new principle to attenuate ischemia-reperfusion injury in kidney transplantation

Ischemia-reperfusion injury in transplantation remains a significant clinical challenge with regard to both short-term and long-term complications. In this study, we developed a new amphiphilic construct, polyethylene glycol (PEG)-conjugated lipids (PEG-LIPIDs), to be administered ex vivo intra-arterially to procured porcine kidney allografts before reperfusion. The aim was to create a protective

Commensal Peptoniphilus harei induce activation of monocytes via TLR2/CD14 signalling in whole blood

Myeloid cells, such as monocytes, are central in the immune response to infections. However, limited knowledge exists regarding the inflammatory response to Gram-positive anaerobic cocci (GPAC). To explore the ability of GPACs to induce monocyte activation, we compared two GPAC species, Parvimonas micra and Peptoniphilus harei, with E. coli, a major cause of bloodstream infections. We stimulated w

Adaptive Gen-AI Guidance in Virtual Reality : A Multimodal Exploration of Engagement in Neapolitan Pizza-Making

Virtual reality (VR) offers promising opportunities for procedural learning, particularly in preserving intangible cultural heritage. Advances in generative artificial intelligence (Gen-AI) further enrich these experiences by enabling adaptive learning pathways. However, evaluating such adaptive systems using traditional temporal metrics remains challenging due to the inherent variability in Gen-A

A skin colonizer disrupts inflammatory and humoral immune defenses in hidradenitis suppurativa

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with a polybacterial dysbiosis devoid of a known pathogen. Here, we report that HS patients mount IgA and IgG responses against skin colonizers, notably Porphyromonas uenonis (Pu), a rare species selectively enriched in severe disease. In these patients, Pu foci are detected in the epidermis, surrounded by IgA deposits

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eurosotl issotl Transforming patterns through the scholarship of teaching and learning THE 2ND EUROPEAN CONFERENCE FOR THE SCHOLARSHIP OF TEACHING AND LEARNING | LUND, SWEDEN, JUNE 8-9 2017 | LUND UNIVERSITY The 2nd EuroSoTL conference, June 8-9 2017, Lund, Sweden Table of Content – at a glance 1 Table of content – at a glance 2-5 Programme 6 Foreword 7 Lund University celebrates 350 years 8 Keyno

https://konferens.ht.lu.se/fileadmin/_migrated/content_uploads/EuroSoTL2017_FullProceedings.pdf - 2026-05-11

Utilization of hardwood in cross-laminated timber

Utilization of hardwood in cross-laminated timber Master’s Dissertation Structural Mechanics JOHANNES JONASSON and OLLE KARLSSON UTILISATION OF HARDWOOD IN CROSS-LAMINATED TIMBER A numerical study on vibrations in floors DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF STRUCTURAL MECHANICS ISRN LUTVDG/TVSM--22/5258--SE (1-133) | ISSN 0281-6679 MASTER’S DISSERTATION Supervisor: PETER PERSSON, Associ

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5258.pdf - 2026-05-14

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Licentiate Dissertation Structural Mechanics ANNIE BOHMAN Report TV SM -3084 A N N IE BO H M A N IM PR O V IN G V IB R A TIO N PER FO R M A N C E O F C R O SS-LA M IN A TED TIM B ER PA N ELS - A co m p u tatio n al in vestig atio n IMPROVING VIBRATION PERFORMANCE OF CROSS-LAMINATED TIMBER PANELS A computational investigation DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF STRUCTURAL MECHANICS ISRN

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm3000/web3084.pdf - 2026-05-14

25.zlatev-final

25.zlatev-final 1
 
 In:
Shaun
Gallagher
and
Dan
Schmicking
(eds)
Handbook
on
Phenomenology
and
Cognitive
 Science,
415‐446.
Dordrecht:
Springer.
 Phenomenology and Cognitive Linguistics Jordan Zlatev Centre for Languages and Literature, Lund University Centre for Cognitive Semiotics (CCS) 1. Introduction The purpose of this chapter is to describe some similarities, as well as differences, between

https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_ccs/ZlatevPhenoCL2010.pdf - 2026-05-14

Forskning – Biologibloggen

Forskning – Biologibloggen Hoppa till huvudinnehåll Om Biologibloggen Tillgänglighet Kontakt Sök Sök Stäng Meny Biologibloggen Biologiska institutionen | Lunds universitet Arkiv för kategorin Forskning Sida 1 / 11 januari 29, 2025 | Inger Ekström Dagordning för FUNs möte den 30/1 -25 Torsdagen den 30 januari klockan 14.15 har forskarutbildningsnämnden möte i Darwin i Ekologihuset. Följande står på

https://biologi.blogg.lu.se/category/forskning/ - 2026-05-14