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The paper discusses different notions of social reality in cultural theory, social theory and literature, for instance in th work of Gottfried Benn, Hans Blumenberg, Michel Foucault, Robert Musil, and Paul Valéry.

BACKGROUND: As trials of 5 years of tamoxifen in early breast cancer mature, the relevance of hormone receptor measurements (and other patient characteristics) to long-term outcome can be assessed increasingly reliably. We report updated meta-analyses of the trials of 5 years of adjuvant tamoxifen.METHODS: We undertook a collaborative meta-analysis of individual patient data from 20 trials (n=21,4

Migration is a psychosocial challenge, and migrants' transitory experiences in host countries are shaped by a combination of linked environmental factors. The absence of social aspects of resilience, as well as disciplinary limitations and biases, hinder the methodological rigor and flexibility needed to investigate social resilience as a phenomenon that occurs at the intersection of social, cultu

At the current time, social robots are poised to enter human society in an unprecedented way. However, robots currentlyare not adept at communicating emotional states, even if humans to a large extent rely on such communication to regulateinteraction. Although facial expressions are difficult for robots to make use of, colored lights are readily available. Currentlythough, there is no consensus on

A new topic that during the last years has come to the attention of researchers is supply chain security. Stakeholders are progressively realizing the importance to join the authority regulations issued by governments (e.g. AEO) to reduce transport delays at Customs or other business certifications (e.g. TAPA) to reduce theft or counterfeiting. However the differences and impacts of security certi

Popular Abstract in Swedish Kan immunförsvaret orsaka ledsjukdomar? Ett väl fungerande immunsystem är en förutsättning för att kroppen ska kunna bekämpa diverse sjukdomar orsakade av t. ex. virus och bakterier. En grundläggande egenskap hos immunsystemet är dess förmåga att kunna skilja på vad som är kroppens egna celler och molekyler och vad som är främmande. Man tror att vissa sjukdomar, så kalCollagen-induced arthritis (CIA) is a mouse model for rheumatoid arthritis, in which autoimmunity is induced by immunization with type II collagen (CII), a cartilage-specific protein. In the present work, alpha/beta T cells were shown to be required for CIA and for the production of anti-CII IgG antibodies, whereas gamma/delta T cells were neither necessary nor sufficient for development of CIA. A

The growth of social science and sociology during modernity has always been characterized by a will to create predictability for human actions, under the modern conditions of liberty seen as contingent, unpredictable and unstable. To gain systematic knowledge became a way to solve, counteract or radicalize tensions in society, and thus outweighing the risks of contingency. Furthermore, this develo

The paper discusses the modern metropolis as modernity in nucleo. Thereby it refers to notions like state of emergency, provisional realities, crisis, contingency, complexity. Recurrent references include Simmel, Blumenberg, Musil, Park.

Background: Individuals’ perception of their work climate is expected to strongly influence personnel’s organizational commitment. However, the evidence about the association between organizational commitment and important outcomes, such as performance at work and turnover, is mixed. If this was not enough, little attention has been paid to how individual differences in basic personality (e.g., in

BACKGROUND: When more patients with congenital heart disease reach adult age, increased incidence of long-term complications, including ischemic stroke, are expected. The aim of this study was to analyze cumulative incidence of ischemic stroke, associated factors, and case fatality in adult congenital heart disease. METHODS AND RESULTS: The study is based on Swedish national registers on congenita

OBJECTIVES: Vesicular drug delivery has become a useful approach for therapeutic administration of pharmaceutical compounds. Lipid vesicles have found application in membrane biology, immunology, genetic engineering and theragnostics. This review summarizes topical delivery, specifically dermal/transdermal, ocular and transungual, via these vesicles, including future formulation perspectives. KEY

Background: Monitoring metabolites of tamoxifen, such as endoxifen, has been suggested as a strategy to ascertain therapeutic effect of tamoxifen therapy, but clinical guidelines are missing. Herein, we aim to investigate the outcome of endoxifen concentrations of low-dose tamoxifen, using change in mammographic breast density as a proxy for therapy response. Methods: In the randomized KARISMA-Tam

Polyploidy and metastasis are associated with a low probability of disease-free survival in cancer patients. Polyploid cells are known to facilitate tumorigenesis. However, few data associate polyploidization with metastasis. Here, by generating and using diploid (2n) and tetraploid (4n) clones from malignant fibrous histiocytoma (MFH) and colon carcinoma (RKO), we demonstrate the migration and in