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BACKGROUNDAmyloid beta (Aβ) antibodies are the only therapies to slow cognitive decline in Alzheimer's disease (AD). Yet the sites where antibodies engage Aβ in the brain and mechanisms that lower Aβ are not fully understood. Defining Aβ antibody localizations in the brain is essential to understand how immunotherapy is beneficial for AD.METHODSN-terminal Aβ antibody 6E10 was injected via three di
The European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on Quality of Life (QoL) and Patient Oriented Outcomes, Melanoma and Non-Melanoma Skin Cancer (NMSC) present a review of the literature and position statement on health-related (HR) QoL assessment in skin cancer patients. A literature search was carried out to identify publications since 1980 that included information abo
The critical impact of air pollution on human health and environment in one hand and the complexity of pollutant concentration behavior in the other hand lead the scientists to look for advance techniques for monitoring and predicting the urban air quality. Additionally, recent developments in data measurement techniques have led to collection of various types of data about air quality. Such data
In the present work, f-wave morphology is characterized by principal component analysis and a novel temporal parameter defined by the cumulative normalized variance of the 3 largest principal components (r3). The 7-day behavior of persistent atrial fibrillation (AF) was studied in 9 patients using r3, AF frequency, and sample entropy (SampEn). Detection of circadian rhythms depended on the paramet
Structure-borne vibration and low-frequency re-radiated noise from internal and external sources cause annoyance for inhabitants in dwellings. A key parameter in the prediction of vibration and noise levels is the modal parameters of the floors in a building, since vibration and sound levels increase when natural frequencies of the floor coincide with the excitation frequencies of a source, e.g. m
Ethical and legal questions of robotic personalisation can be addressed in various ways. While seeking to theorise on ethical issues related to robotic personalisation, this paper proposes the concept of necrorobotics in order to target a particular space of personalisation, governed by a variety of norms: death, and the reuse of dead persons data to create robotic agency. Based on recent advancem
Conventional technical system is designed with all details in the product development phase. Conditions of operation and modes of behaviour are known and validated before the product is launched to the market. This deterministic way of thinking is built into regulations procedures and it is requested at validation when safety is an issue. The existing way of validation that is based on predictive
Introduction: Targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) has been recommended in international guidelines since 2005. The TTM-trial published in 2013 showed no difference in survival or neurological outcome for patients randomised to 33 °C or 36 °C, and many hospitals have changed practice. The optimal utilization of TTM is still debated. This study aimed to
Background: Previous research has revealed a clear relationship between weight gain of persons and their metabolic diseases developing later. These studies have covered only short periods lasting 4–8 years. Our goal was to collect decades’ old and often life-long anthropometric data and correlate the figures with the presence of hypertension and diabetes or both. Methods: A retrospective internat
Paediatric movement disorders (PMDs) comprise a large group of disorders (tics, myoclonus, tremor, dystonia, chorea, Parkinsonism, ataxia), often with mixed phenotypes. Determination of the underlying aetiology can be difficult given the broad differential diagnosis and the complexity of the genotype–phenotype relationships. This can make the diagnostic process time-consuming and difficult. In thi
Dermatan sulfate epimerase 1 (DS-epi1, EC 5.1.3.19) catalyzes the conversion of d-glucuronic acid to l-iduronic acid on the polymer level, a key step in the biosynthesis of the glycosaminoglycan dermatan sulfate. Here, we present the first crystal structure of the catalytic domains of DS-epi1, solved at 2.4 Å resolution, as well as a model of the full-length luminal protein obtained by a combinati
Objectives To investigate outcome after septal myectomy and to evaluate long-term hemodynamics with exercise echocardiography. Methods This study included 40 consecutive patients operated with septal myectomy for hypertrophic obstructive cardiomyopathy from January 1998 to August 2017 at Skane University Hospital, Lund, Sweden. Perioperative clinical data and echocardiography measurements were rev
In this paper, we introduce a novel framework for semi-parametric estimation of an unknown number of signals, each parametrized by a group of components. Via a reformulation of the covariance fitting criteria, we formulate a convex optimization problem over a grid of candidate representations, promoting solutions with only a few active groups. Utilizing the covariance fitting allows for a hyperpar
Ground vibration from traffic or construction work in cities is a known source of annoyance to inhabitants. However, vibration and re-radiated noise in buildings caused by exterior sources are seldom treated properly in the design process, which may be due to the lack of methodologies that can aid informed decision-making with respect to environmental vibration. To achieve efficient evaluation of
Previous studies have shown that measurements of beluga whale (Delphinapterus leucas) and bottlenose dolphin (Tur-siops truncatus) echolocation signals at off-axis angles may be well modeled using a Gaussian bell function or a chirped Gaussian function as envelope. In this paper, we apply a novel technique, the matched window reassignment, for investigation of a range of models of dolphin echoloca
Desmoplastic small round cell tumor (DSRCT) is a highly aggressive soft tissue tumor primarily affecting children and young adults. Most cases display a pathognomonic EWSR1-WT1 gene fusion, presumably constituting the primary driver event. Little is, however, known about secondary genetic changes that may affect tumor progression. We here studied 25 samples from 19 DSRCT patients using single nucl
The article presents a legal ethnographic study of the contradiction between the rhetoric of return, stressing that rejected asylum seekers should leave the country, and the reality of legally stranded migrants, in a Swedish context. Through an in-depth analysis of three individual asylum case files, the study reveals how a situation comes about where rejected asylum seekers end up as legally stra
Real-time train arrival time prediction is crucial for providing passenger information and timely decision support. The paper develops methods to simultaneously predict train arrival times at downstream stations, including direct multiple output liner regression (DMOLR) and seemingly unrelated regression (SUR) models. To capture correlations of prediction equations, two bias correction terms are t
