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Insights into weak affinity antibody-antigen interactionsStudies using affinity chromatography and optical biosensor

Popular Abstract in Swedish I cellen styrs allt av biomolekylernas förmåga till igenkänning och växelverkan med varandra. Molekylernas speciella egenskaper bygger upp kroppens alla komplicerade funktioner, till exempel immunförsvar, celldelning och muskelarbete. Interaktionerna mellan biomolekylerna kan vara av olika karaktär; de beskrivs som starka eller svaga (affinitet), långsamma eller snabba Molecular recognition and interaction is fundamental for the function of biological systems. The properties of the interacting biomolecules dictate the type of forces involved and the strength and dynamics of the interaction. Many interactions are very strong whereas others exhibit weak affinity. Typically, weak interactions work in concert to trigger a biological response. The advantage with thi

Proper Orthogonal Decomposition for experimental investigation of swirling flame instabilities

An experimental investigation of both confined and unconfined flames on a Triple Annular Research Swirler (TARS) is presented. The paper focuses on post-processing techniques aiming at extracting information on the dynamics that are lost through classical statistics approach. POD together with a derived a-posteriori phase averaging procedure successfully reconstructed the dynamics of flames under

The estrogen receptor in fish and effects of synthetic estrogens in the environment - Ecological and evolutionary perspectives and societal awareness

Popular Abstract in Swedish Vår läkemedelsanvändning har eskalerat de senaste två årtionden och vi har kunnat behandla, bota och förebygga sjukdomar samt minskat antalet oönskade graviditeter i större utsträckning jämfört med förr. Detta har dock också fört med sig negativa effekter och miljöproblem efter att läkemedlen kommer ut i naturen. Ett antal läkemedel är så kallade endokrina störningssubsSynthetic hormones are a group of pharmaceuticals used for various human and animal treatments. However, consumption and disposal of these substances have also given rise to negative effects and environmental problems for organisms in the wild which is why these substances have been classified as estrogenic endocrine-disrupting chemicals (EDCs). Studies on the estrogen receptors (ers) and their ge

Dendritic cell interactions with Gram negative bacteria

Popular Abstract in Swedish För att skydda sig mot omgivande virus, bakterier och parasiter har kroppen utvecklat ett speciellt försvar. Detta försvar utgörs av ett komplext nätverk av celler och lösliga komponenter som interagerar med varandra. En del av kroppens försvar utgörs av fysiska barriärer så som huden och av celler som är specialiserade på att ta upp och döda angripande mikroorganismer.The interaction between murine bone marrow-derived dendritic cells (DC) and the Gram negative bacteria Salmonella typhimurium and Escherichia coli have been characterised. These studies showed that DC phagocytosed and processed S. typhimurium and E. coli expressing defined epitopes for peptide presentation on major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules. Process

Best Practice Guideline: Transportation of People Seated in Wheelchairs, Version 2.21.

Summary, key points: Transport considerations ought to be factored into the initial phase of the wheelchair & seating assessment process. Manufacturers of wheelchairs and seating systems should make information relating to the safe transportation of their products readily available - and easy to understand. With the desire to provide the safest possible transport environment for wheelchair-se

Binding of plasma proteins by Staphylococcus epidermidis: characterisation of protein-protein interactions

Popular Abstract in Swedish Sammanfattning på svenska Stafylokocker ingår i vår normala bakterieflora på hud och slemhinnor, men kan också ge upphov till infektioner. Staphylococcus aureus, den gula stafylokocken, är den vanligaste orsaken till sårinfektioner och "sjukhussjuka", och orsakar allvarliga djupa infektioner i ben, hjärta och andra inre organ, samt blodförgiftning. S. epidermidis, den vCoagulase-negative staphylococci (CoNS), in particular, Staphylococcus epidermidis, have emerged as major nosocomial pathogens associated with infections of implanted medical devices. These organisms, which are among the most prevalent bacteria of the human skin and mucous membrane microflora, gain access to the surface of the implant at the insertion. However, the subsequent infection may erupt u

I track, therefore I Am : Exploring the impact of wearable fitness devices on employee identity and well-being

Corporate wellness programs can help employees improve their health and well-being. There are many advantages to a healthy workforce including increased productivity and lower health insurance premiums. A growing trend in corporate wellness programs is to offer wearable fitness trackers to employees to help them monitor their activity so that they can make better choices about their health. It is

Three Roles for Statistical Significance and the Validity Frontier in Theory Testing

This study offers a method for empirically testing theories operationalized in the form of multivariate statistical models. An innovation of the method is that it distinguishes testing into three separate forms, “effect testing,” “prediction testing,” and “theory testing,”where statistical significance plays a separate role in each one. In another innovation, the researcher specifies not only his

Experimentally measured radiative lifetimes and oscillator strengths in neutral vanadium

We report a new study of the V i atom using a combination of time-resolved laser-induced fluorescence and Fourier transform spectroscopy that contains newly measured radiative lifetimes for 25 levels between 24,648 cm-1 and 37,518 cm-1 and oscillator strengths for 208 lines between 3040 and 20000 from 39 upper energy levels. Thirteen of these oscillator strengths have not been reported previously.

IL-18Rα-deficient CD4+ T cells induce intestinal inflammation in the CD45RBhi transfer model of colitis despite impaired innate responsiveness

IL-18 has been implicated in inflammatory bowel disease (IBD), however its role in the regulation of intestinal CD4+ T-cell function remains unclear. Here we show that murine intestinal CD4+ T cells express high levels of IL-18Rα and provide evidence that IL-18Rα expression is induced on these cells subsequent to their entry into the intestinal mucosa. Using the CD45RBhi T-cell transfer colitis mo

Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets

Tissue damage is usually regarded as a necessary price to pay for successful elimination of pathogens by the innate immune defense. Yet, it is possible to distinguish protective from destructive effects of innate immune activation and selectively attenuate molecular nodes that create pathology. Here, we identify acute cystitis as an Interleukin-1 beta (IL-1β)-driven, hyper-inflammatory condition o

A heterogeneous landscape does not guarantee high crop pollination

The expansion of pollinator-dependent crops, especially in the developing world, together with reports of worldwide pollinator declines, raises concern of possible yield gaps. Farmers directly reliant on pollination services for food supply often live in regions where our knowledge of pollination services is poor. In a manipulative experiment replicated at 23 sites across an Ethiopian agricultural

Transition Metal Ions in Atmospheric Waters. 4.1 Metal Ion Catalyzed Autoxidation of Dissolved Sulfur Dioxide

The overall kinetics for manganese(II/III) catalyzed autoxidation of dissolved sulfur dioxide has been studied by UV-vis spectrophotometry. A free-radical mechanism has been proposed, and the rate constant for one of the key reactions between manganese(II) and peroxomonosulfate has been determined by pulse radiolysis. Previous literature on manganese catalyzed autoxidation of SO2(aq) has been thor

Designing for including children in online health care consultations

Children can and should be encouraged to take an active part in their own care. With the introduction of online health care centers, where the main interaction is provided through digital consultations, the process for including the child must be revised. In addition to the medical and legal challenges, the digital interface needs to be designed so that the parent is encouraged to involve the chil

A reduced population of CD103+CD11b+ dendritic cells has a limited impact on oral Salmonella infection

CD103+CD11b+ dendritic cells (DC) are the major migratory DC subset in the small intestine lamina propria (siLP) and their survival is dependent on the transcription factor interferon regulatory factor 4 (IRF4). Mice with a DC-specific deletion of irf4 (CD11c-cre.Irf4 mice) have reduced mucosal CD103+CD11b+ DC and altered T cell differentiation to protein antigen. The influence of CD103+CD11b+ DC

Storstadens dagbok : Boulevardpressen och mediesystemet i det sena 1800-talets Stockholm

Den här avhandlingen undersöker Stockholms boulevardpress under det sena 1800-talet. Studiens huvudsakliga empiriska material utgörs av de fyra boulevardveckotidningarna Figaro, Vikingen, Budkaflen och Hvad Nytt. Boulevardpressens största intresse var den lokala societeten och de teatrar och restauranger den frekventerade. Syftet med avhandlingen är att undersöka tidningstypen med särskild hänsyn