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Background: The members of the Task Force on Contact Dermatitis and the Task Force on Occupational Dermatoses of the European Academy of Dermatology and Venereology (EADV), of the European Dermatology Forum (EDF), and the members of the UEMS Section of Dermatology-Venereology (UEMS-EBDV) we want to vindicate the fundamental role that the specialist in Dermatology has in the diagnosis and managemen

Background AGT (angiotensinogen) synthesis occurs in renal proximal tubular epithelial cells, independent from systemic AGT , as a component of the intrarenal renin-angiotensin system. We investigated urinary AGT , as a biomarker for renin-angiotensin system activation, and electrolyte concentrations, in relation to glomerular volume, as a proxy for glomerular endotheliosis in renal biopsy tissue

Fashion is a social phenomenon par excellence. A simple sociological definition of fashion is 'being first with the latest.' Its underlying principle is revealed in the link between the modus derivatives and the term 'modern,' with its original meaning of 'now' or 'for today.' Fashion revolves around imitation and diffusion, and it applies to all domains of social life, though most of the research

Background--Interleukin-23 (IL-23) has been implicated in inflammatory and autoimmune diseases by skewing CD4+ T helper cells towards a pathogenic Th17 phenotype. In this study we investigated the presence of IL-23 receptor (IL-23R)-expressing cells in the atherosclerotic aorta and evaluated the effect of IL-23R deficiency on atherosclerosis development in mice. Methods and Results--We used hetero

BACKGROUND: Pseudocereals are nutrient-rich grains with high mineral content but also phytate content. Phytate is a mineral absorption inhibitor. The study's aim was to evaluate phytate degradation during spontaneous fermentation and during Lactobacillus plantarum 299v® fermentation of quinoa, canihua, and amaranth grains and flours. It also aimed to evaluate the accessibility of iron, zinc, and c

Background: The affective profiles model has been used in several studies investigating individual differences in, for example, well-being and ill-being. The model categorizes individuals in four profiles based on the balance of high/low positive/negative affect: (1) self-fulfilling (high positive affect, low negative affect); (2) high affective (high positive affect, high negative affect); (3) lo

This review examines the hidden and invisible labor humans perform to enable robots to function as agents within Human-Robot Interaction (HRI). While robot agency is often framed as internal and autonomous, this perspective overlooks the relational dynamics that sustain robot functionality in real-world settings. Drawing on feminist theory, the review highlights how humans frequently share the res

Background: Interleukin-6 is dysregulated in multiple pathological conditions, e.g., cancer and inflammatory diseases. Aim: To investigate new mechanisms for the regulation of pathological IL-6 production. Methods: PBMCs (peripheral blood mononuclear cells) stimulated by cancer serum factors or specific peptides produce interleukin-6 (IL-6). Immunoregulatory albumin neo-structures and peptides wer

Background: Coronavirus disease 2019 (COVID-19) pandemic constituted the largest global health crisis in recent generations. It may also have disrupted the pattern of antimicrobial use (AMU) and subsequently affected the development of antimicrobial resistance (AMR) – a grave human health concern. This study aimed to give an overview of existing AMR surveillance systems and evaluate the impact of

Introduction: Tertiary lymphoid structures (TLS) are lymphocyte aggregates resembling secondary lymphoid organs and are pivotal in cancer immunity. The ambiguous morphological definition of TLS makes it challenging to ascertain their clinical impact on patient survival and response to immunotherapy. Objectives: This study aimed to characterize TLS in hematoxylin-eosin tissue sections from lung can

Two cast Mg–Al–Ba–Ca alloys, DieMag633 and DieMag844, are the focus of this study. Their microstructureMicrostructure consists of a eutectic Ca-rich structure, the lamellar Al2Ca, and of a hard, compact and brittle interdendritic Ba-rich phase, the Mg21Al3Ba2 phase. Both phases have a much higher hardness than the α-Mg matrix and strongly influence the crack propagationCrack propagation under quas

The concept of the rule of law has been a central issue in China for the past two decades, gaining even greater prominence under Xi Jinping’s leadership. This article examines the development of the rule of law in China, drawing on insights from local Chinese scholarship as a vital source for understanding the situation. By analyzing the most cited research articles in the China National Knowledge

Currently, water insecurity is the most common way through which the majority of the global population is experiencing climate change. Projections show that climate change-induced water disasters- floods and droughts chiefly- are expected to increase in the next decades. These circumstances are and will be creating major challenges for peoples’ health and well-being. In this chapter, we present th

"The Value of Knowledge - Towards a Virtue Epistemological Position" The classical question, first posed in Plato's Meno, concerning the value of knowledge constitutes the starting point of this essay. Value analysis has long been neglected in epistemologist's accounts until its re-emergence with the tradition called ?virtue epistemology?, in particular with scholars following Er

Background: Involving librarians as team members can lead to better quality in reviews. To improve their search results, an international diabetes project involved two medical librarians in a large-scale project planning of a series of systematic reviews for clinical guidelines in diabetes precision medicine. Case Presentation: The precision diabetes project was divided into teams. Four diabetes m

This document describes how the Nomenclature for Properties and Units (NPU) terminology can be applied to differentiate between cell subpopulations of the hematopoietic lineage. The clusters of differentiation molecules are included in the NPU syntax, together with its correct affiliations to indicate their presence or absence. This allows for identification and isolation of cell populations, subs

BACKGROUND: Post-acute COVID-19 syndrome (PACS) has been linked to microvascular endothelial dysfunction as a potential underlying pathomechanism and can manifest even following a mild course of the initial infection. Prevalence of microvascular endothelial dysfunction and circulating natriuretic peptides in such PACS patients remains unknown.METHODS AND RESULTS: This prospective, cross-sectional