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Popular Abstract in Swedish Avhandlingen utgörs av studier av smärtupplevelse i olika befolkningsgrupper. I fokus för analyserna står smärtans totala utbredning. Ett beteendepsykolo-giskt perspektiv har applicerats på psykosociala aspekter av betydelse för att hantera den kroniska smärtan. Alla studier har genomförts på urval av Malmöbefolkningen. Bakgrund. Smärtrelaterad arbetsoförmåga är ett foMusculoskeletal pain-related vocational dysfunction is a major public health problem. The solution is beyond the scope of biomedicine, but the problem could well be analyzed in the complementary, cognitive-behavior psychological frame of reference. In order to better prevent the development of pain-related dysfunction: The sociodemographic milieu of dysfunctional chronic pain patients was examined

Popular Abstract in Swedish Immunförsvaret är till för att bekämpa patogener såsom bakterier, virus, parasiter och svamp. Det kan också bekämpa cancerceller även om dessa har en förmåga att undkomma till slut. För att kunna känna igen och eliminera främmande kroppar måste immunförsvaret kunna skilja på dem och våra kroppsegna ämnen. Immunförsvaret består av vita blodkroppar. Vita blodkroppar är enT cells constitute a heterogenous population of lymphocytes. Their unifying property is that they express surface bound antigen-receptors, called T cell receptors (TCRs). The TCR is a heterodimer composed of either TCRalpha and beta chain proteins (alphabeta TCR) or gamma and delta chain proteins (gammadelta TCR). Depending on which TCR isotype that is expressed, the T cells are divided into alpha

Popular Abstract in Swedish Människans immunsystem utgörs av en komplex sammansättning av celler och molekyler, som interagerar med varandra men även med kroppens övriga vävnader. Dess huvudsakliga uppgift är att förse sin värd med ett försvar mot yttre och inre förhållanden, som kan orsaka denna skada, t.ex. bakterie- och virusinfektioner eller betingelser för utveckling av cancer. Denna försvarsThis thesis is based upon four original papers in which human dendritic cells (DCs) and B cells have been analyzed in terms of how they influence the character of adaptive immune responses. DCs isolated from human tonsils were found to possess a capacity to directly regulate proliferation, isotype switching, and antibody production in B cells. DC-produced cytokines, including IL-13, were identifie

Ongoing inflammation including activation of the complement system is a hallmark of systemic lupus erythematosus (SLE). Antimicrobial neutrophil extracellular traps (NETs) are composed of secreted chromatin that may act as a source of autoantigens typical for SLE. In this study, we investigated how complement interacts with NETs and how NET degradation is affected by complement in SLE patients. We

Antibody microarray is a rapidly emerging, powerful approach with great promise within high-throughput proteomics. However, before a truly proteome-wide analysis can be performed, the antibody array format needs to be miniaturized even further in order to enable ultradense arrays to be fabricated. To this end, we have designed and generated proof-of-concept for the first generation of an atto-vial

The use of test coverage measures (e.g., block coverage) to control the software test process has become an increasingly common practice. This is justified by the assumption that higher test coverage helps achieve higher defect coverage and therefore improves software quality. In practice, data often shows that defect coverage and test coverage grow over time, as additional testing is performed. H

A novel immunoassay (PINC-ELISA) was designed using proteinase inhibitors of the cystatin superfamily (PINC) in the solid phase, to promote the selective capture of cysteine proteinases. The method was applied in the identification of papain-like antigens from parasitic protozoa. PINC of human origin, namely recombinant cystatin C (r-cystatin C) or low molecular weight kininogen were used in the a

Antigenic variation in microbial surface proteins represents an apparent paradox, because the variable region must retain an important function, while exhibiting extensive immunological variability. We studied this problem for a group of streptococcal M proteins in which the similar to 50-residue hypervariable regions (HVRs) show essentially no residue identity but nevertheless bind the same ligan

The paper is devoted to an extension of one particular fact withintheory of partial stability, the so-called Pozharitsky Theorem,to the case of partial stabilization of nonlinear controlled system.It is shown that under appropriate assumptions partialstabilization of the system based on usage some Lyapunov functionconstructed from first integrals of the unforced system, impliesthat the Lyapunov fu

This is the first comprehensive monograph on the subject of the architect Fred Forbat. He was a pioneer of functionalism who worked in four different countries. Besides being a presentation of Forbats work, interesting in itself, this investigation also aims at addressing certain questions regarding the history and concept of functionalism as a style and movement. I deal with the work in chronolog

Lumenal entry of plasma (mucosal exudation) is a key feature of airway inflammation. In airways challenged with histamine-type mediators and allergen the mucosal exudation response occurs without causing epithelial derangement and without increased airway absorption. In contrast, reactive oxygen metabolites may cause mucosal damage. In this study, involving guinea-pig airways, we have examined eff

Three-dimensional boundary finding based on Fourier surface optimization is presented as a method for segmentation of SPECT images. Being robust against noise and adjustable with respect to its detail resolution, it forms an interesting alternative in this application area. A three-dimensional approach can also be assumed to increase the possibility of delineating low contrast regions, as compared

A novel heterozygous mutation in the clusterin gene, nucleotide position A1298C (glutamine>proline Q433P), was detected in exon 7 of a child with recurrent hemolytic uremic syndrome (HUS). The same mutation was found in the child's two siblings and mother but not in 120 controls. In addition, a previously described heterozygous mutation was detected in the gene encoding membrane cofactor protein (

Design Thinking is a rather new concept for increasing innovation capabilities in organizations. Organizational Development is a concept from the 1950s aiming at modernizing organizations through participatory methods. As organizations struggle with constant change and to become more innovative we will compare and discuss design thinking and organizational development and explore what we can learn

A battery charger for electric vehicles is to be designed. The charger should have advantageous impact on the utility grid, for example filtering capabilities, reactive power compensation, etc. several battery chargers forms a network where communication between the chargers and the vehicles and some distribution level master controller is an important issue. A possible battery charger topology is

Heparin-binding protein (HBP) is an inducer of vascular endothelial leakage in severe infections. Fluid accumulation into alveoli is a general finding in acute respiratory distress syndrome (ARDS). Severe acute respiratory failure with ARDS is a complication of influenza A(H1N1) infection. Accordingly, we studied the HBP levels in critically ill patients with infection of influenza A(H1N1).Critica