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The development of functionally competent, self-tolerant T cells in the thymus is an essential prerequisite for the formation of adaptive immune responses against foreign pathogens. Thymic epithelial cells (TECs) form specialized stromal microenvironments in the cortex (cTEC) and medulla (mTEC) of the thymus that support all stages of T cell development, from the entry of thymocyte progenitors to

Identification of cancer pathways is the central goal in the cancer gene expression data analysis. A cellular automaton is a dynamic system with cells, which are uniform, interconnected and discrete in nature. Cellular automata are well-known methods to predict network traffics in cellular spaces. Therefore, to predict cancer pathways involved, we propose a 2-dimensional cellular automata approach

Using a novel methodological approach to measure emotions in Facebook comments, this Work in Progress (WIP) paper explores the relationship between negative feelings and ideological cross-posting behavior. Using the VoxPopuli data harvester, we collect over 770,000 public Facebook comments1 from the three major political campaign pages active during the Brexit referendum. After sorting users into

BACKGROUND: Preschool children with autism in southern Sweden participated in a comprehensive Naturalistic Developmental Behavioral Intervention (NDBI) program. AIMS: To evaluate the ongoing NDBI program by comparing the pre- and postintervention outcomes in terms of improved autism symptom severity. METHOD: The improvement of Autism Diagnostic Observation Schedule (ADOS-R) test results between ba

Background-Fetal exposure to preeclampsia is associated with higher blood pressure and later risk of stroke. We aimed to investigate the associations of maternal preeclampsia, gestational hypertension, and maternal blood pressure change in pregnancy with offspring cardiac structure and function in adolescence. Methods and Results-Using data from a prospective birth cohort study, we included offspr

The Monχey project will provide a large and homogeneous set of stellar yields for the low- and intermediate- mass stars and has applications particularly to galactic chemical evolution modelling. We describe our detailed grid of stellar evolutionary models and corresponding nucleosynthetic yields for stars of initial mass 0.8 M⊙ up to the limit for core collapse supernova (CC-SN) ≈ 10 M⊙. Our stud

Immune checkpoint inhibitors (ICPI), such as ipilimumab [anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) antibody] and nivolumab or pembrolizumab [anti-programmed cell death protein-1 (PD-1) antibodies], improve survival in several cancer types. Since inhibition of CTLA-4 or PD-1 leads to non-selective activation of the immune system, immune-related adverse events (irAEs) are frequent. Enterocoliti

Human enteroviruses (HEV), especially coxsackievirus serotype B (CVB) and echovirus (E), have been associated with diseases of both the exocrine and endocrine pancreas, but so far evidence on HEV infection in human pancreas has been reported only in islets and ductal cells. This study aimed to investigate the capability of echovirus strains to infect human exocrine and endocrine pancreatic cells.

We look at multigrid methods for unsteady viscous compressible flows. We specifically target smoothers that can be used in parallel and without computation of a Jacobian, which are particlarly attractive candidates in the context of Discontinuous Galerkin discretizations. In CFD, a plethora of nonlinear smoothers have been suggested which are hard to analyze. Our methodology is to use a linear mod

Today, simulation of springback has still not reached enough accuracy for acceptance as a production tool in the automotive industry. Further investigations need to be done in order to understand how to improve the results in an efficient way. In order to investigate which parameters that are important for the accuracy in a springback simulation, a parameter study of a U-shaped rail was performed.

Virtual reality carries great promise to facilitate the building process. Some examples are the communication between architects and building companies, sellers and buyers or the community planners and the general public. It is often thought that in order to utilize the possibilities of VR, for example in the above-mentioned contexts, it is necessary to use full-fledged versions of VR including fo

The base (BOP) and the top (TOP) of the world income pyramid represent the poor people and the people from developed countries, respectively. About two-fifths of the world population can be categorized as poor. Poverty is a trap because children born to poor parents are likely to grow up to be poor adults. In recent years, a poverty reduction approach that combines business development with povert

Popular Abstract in Swedish Avhandlingen följer den konfliktladdade relationen mellan far och son i Sven Delblancs författarskap och visar hur en lysande berättarkonst växer fram i samspelet mellan minne och fiktion.In 1991, a year before his death, Sven Delblanc published his highly acclaimed autobiography, Livets ax. At the centre of these childhood memories lies the author’s problematic relationship to his father. In view of the attention attracted by Livets ax, it is not surprising that biographical interpretations of Delblanc’s oeuvre have been predominant. It is evident that the writer’s difficult child

Achieving rapid, intuitive, and error-free robot setup and instruction is a challenge. We present our work towards an assistive infrastructure for robot setup and instruction that attempts to address it. In this paper, we describe the ongoing development of a system that automatically generates multimodal dialogue interaction from product and process ontologies. The prototype currently generates t

When investigating different location and/or system designs the possible variables to take into consideration can differs between the alternatives. Different production system will have different optimal working conditions and hence should be compared with parameters suitable for the actual production system. When planning production and calculating production costs the batch size is of high inter