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Following systemic injection, hematoporphyrin derivative (HPD) is known to be selectively retained in malignant tissue. This property can be used in a two-fold way: a) for localizing tumours by observing the characteristic dual-peaked laser-induced fluorescence from HPD, and b) for photodynamic therapy (HPD-PDT) using a localized HPD-assisted singlet oxygen release induced by irradiation of 630 nm

Background: Evolutionary processes can cause strong spatial genetic signatures, such as local loss of genetic diversity, or conflicting histories from mitochondrial versus nuclear markers. Investigating these genetic patterns is important, as they may reveal obscured processes and players. The maternally inherited bacterium Wolbachia is among the most widespread symbionts in insects. Wolbachia typ

AIMS: Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) have increased prevalence of atrial arrhythmias indicating atrial involvement in the disease. We aimed to assess the long-term evolution of P-wave indices as electrocardiographic (ECG) markers of atrial substrate during ARVC progression. METHODS AND RESULTS: We included 100 patients with a definite ARVC diagnosis according

We study the stability of systems of three giant planets orbiting 3-8 M☉ stars at orbital distances of >10 au as the host star ages through the main sequence (MS) and well into the white dwarf (WD) stage. Systems are stable on the MS if the planets are separated by more than ~9 Hill radii. Most systems surviving the MS will remain stable until the WD phase, although planets scattered on to small p

The rock mass viscous behaviour during tunnel construction is discussed. Initially, a brief introduction to the squeezing phenomenon and its association with the related one of creep is provided. Then, existing simplified models of rheological rock mass behaviour are presented and analysed. The range of the viscoelastic rock parameters identified in the literature for weak rocks is also given and

With all the versatility in structural performance and recent progress in developing magnesium alloys, their Achilles heel remains to be degradation or corrosion property. While applications in mobility demand corrosion protection by all means, bio-medical applications of Mg alloys require well-controlled degradation rates. Meeting these requirements is only possible through the understanding of p

Robustness of distributed routing policies is studied for dynamical flow networks, with respect to adversarial disturbances that reduce the link flow capacities. A dynamical flow network is modeled as a system of ordinary differential equations derived from mass conservation laws on a directed acyclic graph with a single origin-destination pair and a constant inflow at the origin. Routing policies

Background: Variation in the incidence, survival rate and factors associated with survival after cardiac arrest in Europe is reported. Some studies have tried to fill the knowledge gap regarding the epidemiology of out-of-hospital cardiac arrest in Europe but were unable to identify reasons for the reported differences. Therefore, the purpose of this study was to describe European Emergency Medica

Fatigue is one of the principal damage mechanisms in a slender concrete structure under cyclic loads. And needs to be calculated locally through all the structure, considering the lading conditions and the particularities of concrete. The model presented here is capable to account for the fatigue damage in a probabilistic way, relating the annual loading conditions for each point and the degradati

The ability to store and mobilize energy is fundamental for physiologic function. Most excess energy is stored in adipose tissue as triglycerides, which is released as free fatty acids when needed through cellular processes tightly regulated by insulin. Intact adipose cell function is essential to regulate whole-body glucose and lipid metabolism. Several studies have focused on the metabolic impac

Background: There is evidence to suggest that frontline community health workers in Malawi are under-referring children to higher-level facilities. Integrating a digitized version of paper-based methods of Community Case Management (CCM) could strengthen delivery, increasing urgent referral rates and preventing unnecessary re-consultations and hospital admissions. This trial aims to evaluate the a

Following the recent discovery of the first radial velocity planet in a star still possessing a protoplanetary disc (CI Tau), we examine the origin of the planet's eccentricity (e ~0.3). We show through long time-scale (10^5 orbits) simulations that the planetary eccentricity can be pumped by the disc, even when its local surface density is well below the threshold previously derived from short ti

We investigate the adaption of the recently developed exponential integrators called EPIRK in the so-called domain-based implicit-explicit (IMEX) setting of spatially discretized PDE's. The EPIRK schemes were shown to be efficient for sufficiently stiff problems and offer high precision and good stability properties like A- and L-stability in theory. In practice, however, we can show that these st