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Solens påverkan på klimatet är ett hett ämne i dagens klimatdebatt och utgör en av de största osäkerheterna i vår kunskap om klimatsystemet. Det finns flera sätt som förändringar i solaktivitet skulle kunna påverka klimatet på. En av de föreslagna länkarna mellan solaktivitet och klimat är att den galaktiska kosmiska strålningen (GCR) påverkar bildningen av låga moln. På grund av att låga moln harThe solar influence on climate is a hot topic in today’s climate debate and constitutes one of the largest uncertainties in our knowledge about the climate system. There are several ways in which solar activity changes could affect climate. One of the suggested links between solar activity and climate is an influence from galactic cosmic rays (GCR) on the formation of low clouds. Because of the ne

Syftet med denna studie är att undersöka fyra nutida pianopedagogers syn på hur Frédéric Chopins pianometodik har utvecklats från kompositörens tid fram till nutid. Litteraturen som används för denna studie fokuserar på Chopins tankar om undervisning, Chopin-spel under olika tider, samt traditionsöverföring. Studien baseras på personliga intervjuer och en kvalitativ metod. Data samlas in genom intTitle: "Clever, but not Chopinesque" - A study of four contemporary piano pedagogues’views on Frédéric Chopin’s piano method through the years The purpose of this study is to investigate four contemporary piano pedagogues’ views on how Frédéric Chopin’s pedagogical piano method has developed from the time of the composer to the present day. The literature used for this study focused on C

OBJECTIVES: To develop and validate a recombinant vaccine to attenuate inflammation in arthritis by sustained neutralization of the anaphylatoxin C5a. METHODS: We constructed and expressed fusion protein of C5a and maltose binding protein. Efficacy of specific C5a neutralization was tested using the fusion protein as vaccine in three different arthritis mouse models: collagen induced arthritis (CI

We have combined experiments with atomic-scale molecular dynamics simulations to consider the influence of ethanol on a variety of lipid membrane properties. We first employed isothermal titration calorimetry together with the solvent-null method to study the partitioning of ethanol molecules into saturated and unsaturated membrane systems. The results show that ethanol partitioning is considerabl

Plasma cystatin C is increasingly used as a marker of glomerular filtration rate. Most assays for cystatin C are based on turbidimetric or nephelometric detection and studies of other rapid methods are limited. This study aimed to develop and compare differently configured immunoassays for quantification of plasma cystatin C, using recombinant cystatin C and two cystatin C-specific antibodies. Met

The immobilization of functional biomolecules to surfaces is a critical process for the development of biosensors for disease diagnostics. In this work we report the patterned attachment of single chain fragment variable (scFv) antibodies to the surface of metal oxides by the photodeprotection of self-assembled monolayers, using near-UV light. The photodeprotection step alters the functionality at

Galectin-1 (Gal-1) and galectin-3 (Gal-3) exhibit profound but unique immunomodulatory activities in animals but their molecular mechanisms are incompletely understood. Early studies suggested that Gal-1 inhibits leukocyte function by inducing apoptotic cell death and removal, but recent studies show that some galectins induce exposure of the common death signal phosphatidylserine (PS) independent

BACKGROUND: Calcitonin-related peptides have been found in the human prostate, and calcitonin (CT) and calcitonin gene-related peptide (CGRP) have been demonstrated in subpopulations of neuroendocrine (NE) cells. The purpose of this study was to determine the concentrations of CT and CGRP as well as the densities of NE cells in normal prostates, benign prostatic hyperplasia (BPH), and carcinoma of

Chemokine receptor CX3CR1(+) dendritic cells (DCs) have been suggested to sample intestinal antigens by extending transepithelial dendrites into the gut lumen. Other studies identified CD103(+) DCs in the mucosa, which, through their ability to synthesize retinoic acid (RA), appear to be capable of generating typical signatures of intestinal adaptive immune responses. We report that CD103 and CX3C

New basis sets of the atomic natural orbital (ANO) type have been developed for the lanthanide atoms La-Lu. The ANOs have been obtained from the average density matrix of the ground and lowest excited states of the atom, the positive ions, and the atom in an electric field. Scalar relativistic effects are included through the use of a Douglas-Kroll-Hess Hamiltonian. Multiconfigurational wave funct

The study of religion has its historical origin in the confessional education of religious functionaries, which has influenced the structuring of the study. The order of the topics studied has been, as a rule, first, languages relevant for the study of the normative texts, then the interpretation of these texts, followed by the historical development within the religion, its doctrines (systematic

For further investigations in the field of artificial photosynthesis, a model compound, 1, has been developed to mimic the electron-transfer steps from the manganese cluster to P680+ in photosystem II. In this model compound the photosensitizer ruthenium(II)-trisbipyridyl was linked to a manganese(II) ion through a bridging ligand. Photoexcitation of 1 in the presence of the electron acceptor meth

The ubiquitin-editing enzyme A20 (TNFAIP3) and the deubiquitinase CYLD are central negative regulators of NF-kappa B signaling. Both can act by removing nonproteolytic K63-linked polyubiquitin chains from an overlapping set of signaling molecules. In B cells, A20 deficiency results in hyperactivity, loss of immune homeostasis, inflammation, and autoimmunity. The reported consequences of CYLD defic

"When we celebrate the days of our deceaced brothers" -- texts for the Office of the dead in Liber daticus vetustior