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The Papuan languages on the islands of Timor, Alor, Pantar and Kisar have typically been supposed to be related to one another. Based on their geographical proximity, this assumption of relatedness has been supported by impressionistic assessments of lexical and phonological similarity and the results of lexicostatistical measurements. Whilst recent historical work has shown definitively that the
Popular Abstract in Swedish Helicobacter pylori är en spiralformad Gramnegativ human-specifik patogen, som kan penetrera magsäckens slemlager och kolonisera epitelskiktet. H. pylori infektion är en högriskfaktor för utvecklandet av kronisk gastrit, magsår och ventrikelcancer. Både aktivt växande spiralformer av H. pylori och dess runda viloformer framkallar kronisk magkatarr (gastrit) i BALB/cA möHelicobacter pylori is a human pathogen strongly associated with chronic type B gastritis, peptic ulcer disease, gastric cancer and MALT lymphoma. Our aims were to establish a mouse model of H. pylori infection, to study pathogenesis of gastritis and gastric cancer and to investigate new treatment strategies in this model. Both spiral and coccoid forms of H. pylori strains 17874, 25 and 553/93 cau
This paper consists of two, somewhat disparate parts. In the first part, some experiences of two years of fieldwork are summarized, concentrating, as the subtitle suggests, on the very heart of phonetic fieldwork: the encounters and interviews with the informants. As a result of the fieldwork, the project now has access to recordings from approximately 1300 speakers of more than 100 dialects of Sw
We have cloned a cDNA for a myocardial cGMP-inhibited cAMP phosphodiesterase (cGI PDE) from a human heart cDNA library in lambda Zap II. The open reading frame [3.5 kilobases (kb)] of cDNA clone n.13.2 (7.7 kb) encodes a protein of 125 kDa. In Northern blots of total human ventricle RNA, a single mRNA species (8.3 kb) hybridized with a 4-kb EcoRI restriction fragment of clone n.13.2 cDNA (containi
This study addressed the contribution of ADAMTS13 deficiency to complement activation in thrombotic thrombocytopenic purpura (TTP). Renal tissue and blood samples were available from 12 TTP patients. C3 and C5b-9 deposition were demonstrated in the renal cortex of two TTP patients, by immunofluorescence and immunohistochemistry, respectively. C3 was also demonstrated in the glomeruli of Shiga toxi
Breast cancer type 1 susceptibility protein (BRCA1) has a multitude of functions that contribute to genome integrity and tumor suppression. Its participation in the repair of DNA double-strand breaks (DSBs) during homologous recombination (HR) is well recognized, whereas its involvement in the second major DSB repair pathway, nonhomologous end-joining (NHEJ), remains controversial. Here we have st
The Gaia mission has been designed to perform absolute astrometric measurements with unprecedented accuracy; the end-of-mission parallax standard error is required to be of the order of 10 mu as for the brightest stars (V= 10) and 30 mu as for a G2V-type star of magnitude 15. These requirements set a stringent constraint on the accuracy of the estimation of the location of the stellar image on the
BACKGROUND Neuroendocrine (NE) cells are frequently present in the human prostate and urethra, whereas they are lacking in the other urogenital organs. This study was undertaken as there are only few detailed studies available on the distribution, form and function of NE cells and the structure of excretory ducts of the accessory sex organs in the male rat.
Recent technological innovation has opened new avenues in migration research - for instance, by allowing individual migratory animals to be followed over great distances and long periods of time, as well as by recording physiological information. Here, we focus on how technology - specifically applied to bird migration - has advanced our knowledge of migratory connectivity, and the behavior, demog
In the past decade, many initiatives were taken for the development of antibodies for proteome-wide studies, as well as characterisation and validation of clinically relevant disease biomarkers. Phage display offers many advantages compared to antibody generation by immunisation because it is an unlimited resource of affinity reagents without batch-to-batch variation and is also amendable for high
This text is an analysis of the reception of Steven Spielberg´s film Schindler´s List in the Czech Republic. Being a Sudeten German, Oskar Schindler, the hero of the film and the rescuer of hundreds of Jews from the Nazi destruction machinery, made Czechs aware not only or primarily of the atrocities of the Holocaust, but of several Czech-German troublespots of the past, including those related to
Recent three-dimensional, high-resolution simulations of neutron star coalescences are analysed to assess whether short gamma-ray bursts (GRBs) could originate from such encounters. The two most popular modes of energy extraction - namely the annihilation of and magnetohydrodynamic processes - are explored in order to investigate their viability in launching GRBs. We find that annihilation can pro
The organisational network of global environmental governance (GEG) mirrors the complexity of the planet's manifold and overlapping ecosystems. Bursting onto the international stage in the 1970s, environmental issues began to be addressed by a series of new international organisations, most of them affiliated with the United Nations. Some of them, such as the United Nations Environment Programme (
Popular Abstract in Swedish Cancer är en komplex och heterogen sjukdom där celler har börjat växa okontrollerat och denna sjukdom är idag ett stort hälsoproblem. På grund av diffusa symptom upptäcks cancern ofta i ett sent stadium. Otillräcklig kunskap om olika fenotyper hindrar utvecklingen av riktad behandling och patienter svarar därför väldigt olika på en given behandling. Denna avhandling ärCancer is a complex and heterogeneous disease where cells have started to grow uncontrolled and this disease remains a major health problem. Because of diffuse symptoms it often presents at a late stage. Insufficient understanding of the different phenotypes hinders the development of targeted therapeutics and consequently patients show a diverse range of responses to a given treatment. This thes
