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The motion of pre-existing edge dislocations in an infinite linear elastic body is studied. Motion is due to a quasi-statically steady-state growing crack. In the model, the dislocations glide if the force on the dislocation exceeds a critical value. Obtained results are changes in dislocation density, the shielding effect on the crack tip and residual stresses. The model is applied to an isotropi

BACKGROUND: Male arginine vasopressin 1a receptor knockout mice (V1aR(-/-)) display a phenotype of low triglycerides and high glucose concentrations and high-fat-diet-induced obesity and diabetes. OBJECTIVE: We investigated whether genetic variation of the human arginine vasopressin 1A (AVPR1A) gene is associated with phenotypic features resembling those of the V1aR(-/-) mouse. DESIGN: In a popula

Automatic detection of five language components, which are all relevant for expressing opinions and for stance taking, was studied: positive sentiment, negative sentiment, speculation, contrast and condition. A resource-aware approach was taken, which included manual annotation of 500 training samples and the use of limited lexical resources. Active learning was compared to random selection of tra

Cancer-associated fibroblasts (CAFs) regulate tumour growth, metastasis and response to treatment. Recent studies indicate the existence of functionally distinct CAF subsets. Suggested mechanisms whereby CAFs can impact on treatment response include paracrine signaling affecting cancer cell drug sensitivity and effects on tumour drug uptake. PDGFRβ is an important regulator of fibroblasts. Experim

We introduce an axiomatization for the coalgebraic fixed point logic which was introduced by Venema as a generalization, based on Moss' coalgebraic modality, of the well-known modal mucalculus. Our axiomatization can be seen as a generalization of Kozen's proof system for the modal mu-calculus to the coalgebraic level of generality. It consists of a complete axiomatization for Moss' modality, exte

Hyperplasia of the middle ear mucosa contributes to the sequelae of acute otitis media. Understanding the signal transduction pathways that mediate hyperplasia could lead to the development of new therapeutic interventions for this disease and its sequelae. Endotoxin derived from bacteria involved in middle ear infection can contribute to the hyperplastic response. The p38 mitogen-activated protei

The stars that populate the solar neighbourhood were formed in stellar clusters. Through N-body simulations of these clusters, we measure the rate of close encounters between stars. By monitoring the interaction histories of each star, we investigate the singleton fraction in the solar neighbourhood. A singleton is a star which formed as a single star, has never experienced any close encounters wi

The very bright red star HV2112 in the Small Magellanic Cloud could be a massive Thorne-A >> ytkow object (TA >> O), a supergiant-like star with a degenerate neutron core. With a luminosity of over 10(5) L-aS (TM), it could also be a super asymptotic giant branch (SAGB) star, a star with an oxygen/neon core supported by electron degeneracy and undergoing thermal pulses with third dredge up. Both T

We report experimental oscillator strengths for 88 Ti I transitions covering the wavelength range 465-3892 nm, 67 of which had no previous experimental values. Radiative lifetimes for 13 energy levels, including the low energy levels 3d(2)(F-3) 4s4p ((3)p) z(5)D(j)degrees have been measured using time-resolved laser-induced fluorescence. Intensity-calibrated Ti I spectra have been measured using F

We study the nature of the peculiar [Sr II] and Sr II emission filament found in the ejecta of Eta Carinae. To this purpose we carry out abinitio calculations of radiative transition probabilities and electron impact excitation rate coefficients for Sr II. Then we build a multilevel model for the system which is used to investigate the physical condition of the filament and the nature of the obser

Maternal effects by which females provide their offspring with non-genetic factors such as hormones, nutrients and antibodies can have an important impact on offspring fitness. In vertebrates, maternal antibodies (matAb) are transferred from the mother, via the placenta, egg yolk or milk during lactation to offspring until they are 2 weeks (birds), 4-10 weeks (rodents) and 9 months (humans) old, r

BACKGROUND. The clinical value of detecting prostate specific antigen (PSA) mRNA in the peripheral blood mononuclear cell fraction of patients (pts) by standard RT-PCR assays with localized prostate cancer remains controversial. We used a quantitative RT-PCR assay to measure the PSA mRNA copy number in addition to the qualitative PSA RT-PCR and correlated the results with clinical parameters. METH

Helicobacter pylori infection is associated with gastritis, ulcerations, and gastric adenocarcinoma. H. pylori secretes the vacuolating cytotoxin (VacA), a major pathogenicity factor. VacA has immunosuppressive effects, inhibiting interleukin-2 (IL-2) secretion by interference with the T cell receptor/IL-2 signaling pathway at the level of calcineurin, the Ca2+-calmodulin-dependent phosphatase. He