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Otitis media with effusion (OME) is a common inflammatory disease, primarily affecting children. OME is defined as a chronic low-grade inflammation of the middle ear (ME), without any signs of infection and with effusion persisting in the ME for more than three months. The precise pathogenesis is, however, not fully understood. Here, we comprehensively characterized and compared the host immune re

Olyckor vid vägarbetszoner är ett ihållande trafiksäkerhetsproblem i många europeiska länder. IRIS-projektet (Incursion Reduction to Increase Safety in road work zones) finansierat av CEDR samlade in information om bästa praxis inom trafikledning vid vägarbetsplatser. En analys av olyckor i arbetszonen och en översyn av bästa praxis gjordes. Psykologiska problem för att förbättra säkerheten i arbeAccidents nearby work zones are a persistent road safety problem in many European countries. The Conferenceof European Directors of Roads (CEDR) has initiated and finances the IRIS project (Incursion Reduction toIncrease Safety in road work zones) with the aim to collect and share information about best practices in temporarytraffic management at road works. An analysis of work zone accidents and

The mechanisms underlying M. fortuitum-induced pathogenesis remains elusive. Using headkidney macrophages (HKM) from Clarias gariepinus, we report that TLR-2-mediated internalization of M. fortuitum is imperative to the induction of pathogenic effects. Inhibiting TLR-2 signalling alleviated HKM apoptosis, thereby favouring bacterial survival. Additionally, TLR-2-mediated cytosolic calcium (Ca2+)c

Background Genome-wide association studies have identified >1000 genetic variants cross-sectionally associated with blood pressure variation and prevalent hypertension. These discoveries might aid the early identification of subpopulations at risk of developing hypertension or provide targets for drug development, amongst other applications. The aim of the present study was to analyze the associat

The presented work describes a computational method for carrying out a detailed and thorough examination of the flash temperature rise (i.e. the local’instantaneous’ temperature increase on a contact interface, due to frictional effects) present on the tooth flanks of a polymer gear pair, composed of a combination of POM and PA66 thermoplastics, during a given meshing cycle. The method involves a

The pharmaceutical approach to skin disease has been hugely successful, but despite effective drugs being available and used, there are still vast numbers of people who continue to have some level of persisting skin disease and continue to experience quality of life (QoL) impairment. So the question that needs to be answered, while we await further advances in our drug-based armamentarium, is how

Platelets are the primary cellular mediators of hemostasis and this function firmly acquaints them with a variety of inflammatory processes. For example, platelets can act as circulating sentinels by expressing Toll-like receptors (TLR) that bind pathogens and this allows platelets to effectively kill them or present them to cells of the immune system. Furthermore, activated platelets secrete and

Solar energy simulations are used to quantify the potential of the passive use (daylight, solar gains) and the active use (photovoltaics and solar thermal) of solar energy. The simulations can be performed at different scales e.g. buildings, neighbourhoods and cities, with different requirements on the data. For example, for the neighbourhood simulations we need simplified building geometries that

Purpose: The purpose of this document is threefold: (a) review the uses of the terms “vocal fatigue,” “vocal effort,” “vocal load,” and “vocal loading” (as found in the literature) in order to track the occurrence and the related evolution of research; (b) present a “linguistically modeled” definition of the same from the review of literature on the terms; and (c) propose conceptualized definition

This article explores how the NT accounts of the rending of the veil in the Temple at the time of Jesus have been interpreted: as a sign of wrath, joy and grief.

n this paper a hardware architecture for an OFDM synchronizer is presented. The proposed synchronization unit can be used in any OFDM system that uses a cyclic prefix. The algorithm is based on the correlation introduced by the cyclic prefix, which is exploited in the time domain where both time and frequency offset are estimated simultaneously. The synchronization unit also performs frequency cor

This paper presents in some detail findings and experiences gained from a new course entitled “Innovation Engineering” (IE). This course is offered in the Technology Management Programme (TM) at Lund University, Lund, Sweden. The incentive for developing the new course was the need for a more integrated and practical approach where technical, customer and application problems from reality confront

The elemental composition of the St. Louis aerosol has been investigated at rooftop sites in south and central locations in the city as part of the August, 1973 field season of the Regional Air Pollution Study of the U.S. Environmental Protection Agency. Sampling by 5-stage cascade impactor with backup filter permits analysis by proton-induced x-ray emission (PIXE) of size fractions of aerodynamic