Filetype
We investigate a class of random graph ensembles based on the Feynman graphs of multidimensional integrals, representing statistical-mechanical partition functions. We show that the resulting ensembles of random graphs strongly resemble those defined in random graphs with hidden color, generalizing the known relation of the Feynman graphs of simple one-dimensional integrals to random graphs with a
The nociceptive spinal reflex system performs highly precise sensorimotor transformations that require functionally specified synaptic strengths. The specification is gradually attained during early development and appears to be learning dependent. Here we determine the time course of this specification for heat-nociceptive tail withdrawal reflexes and analyze which types of primary afferents are
Due to their small size, nanoparticles have distinct properties compared with the bulk form of the same materials. These properties are rapidly revolutionizing many areas of medicine and technology. Despite the remarkable speed of development of nanoscience, relatively little is known about the interaction of nanoscale objects with living systems. In a biological fluid, proteins associate with nan
Within the framework of a simple model of photophysical processes in the Weigelt blobs in the vicinity of the luminous blue variable (LBV) star eta Carinae, we explain the presence of the fluorescent < O I > 8446-angstrom and forbidden [O I] 6300-angstrom lines as well as the absence of the allowed O I 7774-angstrom line in spectra recorded with the Hubble Space Telescope (HST)/STIS instrument (Gu
We describe the design and implementation of a robotic solution to automate the acquisition of gel images. The soft- and hardware aspects are outlined together with the various safety aspects that need to be addressed.
The microbiota is part of the gastrointestinal ecosystem. A more detailed understanding should provide insight into multiple human disease states. This study investigated inflammatory bowel disease (Crohn's disease and ulcerative colitis). Previous analyses have suggested a role of gram-negative bacteria including Escherichia coli. An integrated procedure is presented where gas chromatography-mass
BACKGROUND Linomide, Figure 1, produces robust and consistent in vivo growth inhibition of prostate cancer models via its anti-angiogenic activity and inhibition of autoimmune encephalomyelitis models of multiple sclerosis (MS). MS clinical trials were discontinued because of unacceptable toxicity, due to dose-dependent induction of proinflammation. METHODS Therefore, linomide analogs were initia
Murine gammadelta T cells participate in innate immune response against infection of the intracellular bacterium Listeria monocytogenes. In the present report, we analyzed the mechanism of the gammadelta T cell-mediated response against L. monocytogenes infection. gammadelta T cell-enriched spleen cells of L. monocytogenes-infected mice produced IFN-gamma in vitro in response to L. monocytogenes-i
Flt3 has emerged as a potential regulator of hematopoietic stem cells (HSC). Sixty percent of cells in the mouse marrow Lin(-)Sca1(+)c-kit(+) HSC pool expressed flt3. Although single cell cloning showed comparable high proliferative, myeloid, B, and T cell potentials of Lin(-)Sca1(+)c-kit(+)flt3(+) and Lin(-)Sca1(+)c-kit(+)flt3(-) cells, only Lin(-)Sca1(+)c-kit(+)flt3(-) cells supported sustained
Allergic rhinitis is a common disease characterized by the symptoms of pruritus, sneezing, hypersecretion and nasal blockage. Increased mucosal barrier permeability has been suggested to be an indicator for the severity of allergic rhinitis. This study investigates the passage of radiolabelled albumin from the nasal mucosal circulation into the lumen in guinea pigs intraperitoneally sensitized and
We used a high-titer recombinant adeno-associated virus (rAAV) vector to express WT or mutant human alpha -synuclein in the substantia nigra of adult marmosets. The alpha -synuclein protein was expressed in 90-95% of all nigral dopamine neurons and distributed by anterograde transport throughout their axonal and dendritic projections. The transduced neurons developed severe neuronal pathology, inc
Selected reaction monitoring (SRM) is a mass spectrometry method with documented ability to quantify proteins accurately and reproducibly using labeled reference peptides. However, the use of labeled reference peptides becomes impractical if large numbers of peptides are targeted and when high flexibility is desired when selecting peptides. We have developed a label-free quantitative SRM workflow
The aim of this article is to contribute to literature with new findings from biogenetics that are becoming increasingly important. In particular, we will discuss the new analytic frameworks that may open as a result of the incorporation of epigenetics in evolutionary economic thinking. This new approach is illustrated by studying the evolution of big Internet industry groups such as Apple, Google
Popular Abstract in Swedish Salmonella infektion drabbar ca 16 miljoner människor i världen per år. Salmonella sprids genom mat och vatten och fšrekommer främst i länder där god hygien är ett problem. Beroende på vilken typ av Salmonella som man infekteras av, kan man drabbas av magsjuka eller en allvarlig systemisk infektion som i värsta fall kan leda till döden (tyfoid feber). Salmonella tar sigThe immune system has several strategies to combat infections. The present study investigates various aspects of the interaction between Gram negative bacteria, particularly Salmonella, and antigen presenting cells (APC). Salmonella is an intracellular bacterium infecting mice and man. Salmonella typhimurium infection in mice is a frequently used model for studying systemic Salmonella infection. O
