Filetype
Antibodies are important proteins participating in a number of reactions to protect us from harmful diseases. Apart from this important function, they are also useful in different technical and medical applications. This, however, relies on our possibility to produce antibodies in vitro. In the first part of my thesis a new technology called CDR shuffling was developed to create diverse and highly
Popular Abstract in Swedish Användningen av konstgjorda material för temporärt och permanent bruk, t.ex katetrar, skruvar, ledproteser är numera väl etablerad inom human- medicinen. Dessa sk biomaterial kan emellertid predisponera till proppbildning, inflammatoriska vävnadsreaktioner och infektioner i omgivande vävnad, ledande till svåra komplikationer, såsom blod- förgiftning, passagestopp samt pResident skin micro-organisms such as S. epidermidis and other coagulase-negative staphylococci (CoNS), are by far the most common causes of biomaterial-associated infections. These micro-organisms often exhibit surface adhesins that specifically bind serum and tissue proteins adsorbed to implanted biomaterials. The aim of this study was to extend our knowledge about such adhesins produced by CoNS
Eukaryotic cells possess sensitive systems for the detection of microbes and microbial-derived products. Bacteria-eukaryotic cells contact triggers several signaling pathways, most of which are dependent on protein-protein interactions followed by phosphorylation, leading to activation of defense mechanisms. Yersinia bacteria have evolved different strategies to interfere with eukaryotic host defe
In this paper we discuss parallelization and distribution of problems modeled in a constraint programming (CP) framework. We focus on parallelization of depth-first search methods, since search is the most time-consuming task in CP. The current hardware development is moving towards multi-core processors and the cost of building distributed systems is shrinking. Hence, parallelization and distribu
This paper describes a system to create animated 3D scenes of car accidents from reports written in Swedish. The system has been developed using news reports of varying size and complexity. The text-to-scene conversion process consists of two stages. An information extraction module creates a structured representation of the accident and a visual simulator generates and animates the scene. We firs
Although bone marrow (BM) represents the main site for postnatal NK cell development, recently a distinct thymic-dependent NK cell pathway was identified. These studies were designed to investigate the role of cytokines in regulation of thymic NK cells and to compare with established regulatory pathways of BM-dependent NK cell compartment. The common cytokine receptor gamma-chain (Il2rg) essential
Streptococcus spp. are important causes of infective endocarditis but challenging in species identification. This study compared identification based on sequence determination of the rnpB gene with 2 systems of matrix-assisted laser desorption ionization-time of flight mass spectrometry, MALDI Biotyper (Bruker) and VITEK MS IVD (bioMérieux). Blood culture isolates of viridans streptococci from 63
Very heavy elements (Pt, Au, Hg, Tl, and Bi) are found to be enhanced inthe atmospheres of the chemically peculiar stars of the upper mainsequence by up to a million times the solar system levels. Suchenhancements are believed to result from atmospheric dynamics (i.e.,diffusion) rather than scenarios that dredge up nuclear-processedmaterial to the surface or transfer processed material between bin
Place-names often reflect local, cultural, and political history. It is only natural, therefore, that words for such historically important phenomena as boundaries should form part of place-names. In England, there is a fair number of place-name elements that refer to boundaries. Some of them are treated in this thesis. They are OE (ge)mǣre, OE mearc, OE *rān, *rǣn(e), ON rein, ON rá, and OE hār.
The adrenal sex hormone dehydroepiandrosterone (DHEA), which is present in serum mainly as the sulfate DHEA-S, is the most abundant steroid hormone in human blood. Its levels decline dramatically with age. Despite the great amount of literature on vascular and metabolic actions of DHEA/-S, evidence for an association between DHEA/-S levels and cardiovascular events is contradictory.
The task of assessing the extent of a gas release during pipeline emergency situations is challenging. Traditional methodologies for risk analysis require significant computer capabilities and time; factors that have traditionally made emergency response teams unable to use gas dispersion modelling during real incidents.
